ID A0A2K6MWU3_RHIBE Unreviewed; 764 AA.
AC A0A2K6MWU3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=P53-induced death domain protein 1 {ECO:0000313|Ensembl:ENSRBIP00000040243.1};
GN Name=PIDD1 {ECO:0000313|Ensembl:ENSRBIP00000040243.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000040243.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000040243.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000040243.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6MWU3; -.
DR Ensembl; ENSRBIT00000064273.1; ENSRBIP00000040243.1; ENSRBIG00000043551.1.
DR GeneTree; ENSGT00940000161780; -.
DR OMA; HRDNLGA; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08779; Death_PIDD; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR019502; Peptidase_S68_pidd.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF10461; Peptidase_S68; 1.
DR Pfam; PF00791; ZU5; 2.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 176..308
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 309..450
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 642..727
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 738..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 298
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 300
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 440
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 442
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT SITE 299..300
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
FT SITE 441..442
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
SQ SEQUENCE 764 AA; 84372 MW; 224BBFC97DEDBF5A CRC64;
MRGLGALLLS HNCLSELPEA LGALPALTFL AVTHNCLQTL PPALGALSTL QRLDLSQNLL
DTLPPEIGGL GSLLELNLAS NRLQSLPASL AGLRSLRLLV LHSNLLASVP ASLARLPLLT
RLDLRDNQLR DLPPELLDAP FVRLQGNPLG EASPDVPSSP VAALIPEMPR LFLTSDLDSF
PVTPRGCSVT LACGVRLQFP AGATATPITI RYRLLLPEPG LVPLGPHDAL LSHVLELQPH
GVAFQQDVGL WLLFTPPRAR RCREVVVRTR NDNSWGDLET YLEEEAPQRL WAHCQAPHFS
WFLVVSRPVS NACLVPPEGT LLCSSGHPGV KVIFPPGATE EPRRVSMQVV RMAGRELQAL
LGEPEAAVSP LLCLSQSGPP SFLQPVTVQL PLPSGVTGLS LDRSRLHLLY WAPPAATWDD
ITAQVVLELT HLYARFQVTH FSWYWLWYTT KNCVGGLARK AWERLRLHRV NLIALQRRRD
PEQVLLQCLP RNKVDATLRR LLERYRGPEP SDTVEMFEGE EFFAAFERGI NVDADRPDCV
EGRICFVFYS HLKNVKEVYV TTTLDREAQA VRGQVSFYRG AVPVQVPEEA EAARQRKGAD
ALWMATLPIK LPRLRSSEEP RWGAGLSLAP LNLGDAETGF LTQSNLLSVA GRLGPDWPTV
ALHLGVSYRE LQRIRHEFRD DLDGQIRHML FSWAERQAGQ PGAVGLLVQA LEQSDRQDVA
EEVRTVLELG CRKYQDRIQR TGLAPKDPAL PGSSAPQPPE PAQA
//
