ID A0A2K6MY42_RHIBE Unreviewed; 778 AA.
AC A0A2K6MY42;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=TLE family member 3, transcriptional corepressor {ECO:0000313|Ensembl:ENSRBIP00000040657.1};
GN Name=TLE3 {ECO:0000313|Ensembl:ENSRBIP00000040657.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000040657.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000040657.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000040657.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6MY42; -.
DR STRING; 61621.ENSRBIP00000040657; -.
DR Ensembl; ENSRBIT00000064690.1; ENSRBIP00000040657.1; ENSRBIG00000043699.1.
DR GeneTree; ENSGT01030000234519; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:1990907; C:beta-catenin-TCF complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF24; TRANSDUCIN-LIKE ENHANCER PROTEIN 3; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 18..137
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 578..619
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 620..661
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 131..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..60
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 145..159
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 778 AA; 83793 MW; 550D0385E8C9BB70 CRC64;
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH
YVMLHVVSLP LQTEIAKRLN TILAQIMPFL SQEHQQQVAQ AVERAKQVTM TELNAIIGVR
GLPNLPLTQQ QLQAQHLSHA THGPPVQLPP HPSGLQPPGI PPVTGSSSGL LALGALGSQA
HLTVKDEKNH HELDHRERES SAVSNNSVSP SESLRASEKH RGSADYSMEA KKRKAEEKDS
LSRYDSDGDK SDDLVVDVSN EDPATPRVSP AHSPPENGLD KARSLKKDAP TSPASVASSS
STPSSKTKDL GHNDKSSTPG LKSNTPTPRN DAPTPGTSTT PGLRSMPGKP PGMDPIGIMA
SALRTPISIT SSYAAPFAMM SHHEMNGSLT SPGAYASLHN IPPQMSAAAA AAAAAYGRSP
MVSFGAVGFD PHPPMRATGL PSSLASIPGG KPAYSFHVSA DGQMQPVPFP HDALAGPGIP
RHARQINTLS HGEVVCAVTI SNPTRHVYTG GKGCVKIWDI SQPGSKSPIS QLDCLNRDNY
IRSCKLLPDG RTLIVGGEAS TLTIWDLASP TPRIKAELTS SAPACYALAI SPDAKVCFSC
CSDGNIAVWD LHNQTLVRQF QGHTDGASCI DISHDGTKLW TGGLDNTVRS WDLREGRQLQ
QHDFTSQIFS LGYCPTGEWL AVGMESSNVE VLHHTKPDKY QLHLHESCVL SLKFAYCGKW
FVSTGKDNLL NAWRTPYGAS IFQSKESSSV LSCDISADDK YIVTGSGDKK ATVYEVIY
//
