ID A0A2K6N0I6_RHIBE Unreviewed; 6567 AA.
AC A0A2K6N0I6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Nebulin {ECO:0000313|Ensembl:ENSRBIP00000041492.1};
GN Name=NEB {ECO:0000313|Ensembl:ENSRBIP00000041492.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000041492.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000041492.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000041492.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSRBIT00000065529.1; ENSRBIP00000041492.1; ENSRBIG00000043974.1.
DR GeneTree; ENSGT00940000154533; -.
DR OMA; WRYREQY; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd11933; SH3_Nebulin_C; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR013998; Nebulin-like.
DR InterPro; IPR000900; Nebulin_repeat.
DR InterPro; IPR035629; Nebulin_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR11039; NEBULIN; 1.
DR PANTHER; PTHR11039:SF37; NEBULIN; 1.
DR Pfam; PF00880; Nebulin; 96.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00510; NEBULIN.
DR SMART; SM00227; NEBU; 174.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51216; NEBULIN; 125.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 6508..6567
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 35..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6427..6464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6480..6505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6427..6447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6567 AA; 761226 MW; 6C75BBE78FAF7580 CRC64;
GSLANAFVLY LQYYTEEVVY EEVPGETITE IYETTTTRTS DYEQSETSKP ALAQPALAQP
APAKPVERRK VIRKKVDPSK FMTPYIAHSQ KMQDLFSPNK YKEKFEKTKG QPYASTTDTP
ELRRIKKVQD QLSEVKYRMD GDVAKTICHV DEKAKDIEHA KKVSQQVSKV LYKQNWEDTK
DKYLLPPDAP ELVQAVKNTA MFSKKLYTED WEADKSLFYP YNDSPELRRV AQAQKALSDV
AYKKGLTEQQ AQFTPLADPP EIEFAKKVTN QVSKVTKYKE DYENKIKGKW SETPCFEVAN
ARMNADNLST RKYQEDFENM KDQIYFMQTE TPEYKMNKKA GVAASKVKYK EDYEKNKGKA
DYNVLPASEN PLLRQLKAAG DALSDKLYKE NYEKTKAKSI NYCETPKFKL DTVLQNFSSD
KKYKDSYLKN ILGHYVGSFE DPYHSHCMRV TAQNSDKNYK AEYEEDRGKG FFPQTITQEY
EAIKKLDQCK DHTYKVHPDK TKFTQVTDSP VLLQAQVNSK QLSDLNYKAK HESEKFKCHI
PPDTPALIQH KVNAYNLSDN LYKQDWEKSK AKKFDIKVDA IPLLAAKANT KNTSDVMYKK
DYEKNKGKMI GALSINDDPK MLHSLKVAKN QSDRLYKENY EKTKAKSMNY CETPKYQLDT
QLKNFSEAKY KDLYVKNILG HYVGSFEDPY HTHCMKVAAQ NSDKSYKAEY EEDKGKCYFP
QTITQEYEAI KKLDQCKDHT YKVHPDKTKF TAVTDTPVLL QAQLNTKQLS DLNYKAKHEG
EKFKCHVPAD APQFIQHRVN AYNLSDNLYK QDWEKSKAKK FDIKVDAIPL LAAKANTKNT
SDVMYKKDYE KSKGKMIGAL SINDDPKILH SLKTAKNQSD REYRKDYEKS KTIYTAPLDM
LQVTQAKKSQ AIASDVDYKH ILHSYSYPPD SINVDLAKKA YALQSDVEYK ADYNSWMKGC
GWVPFGSLEM EKAKRASDIL NEKKYRQHPD TLKFTSIEDA PITVQSKINQ AQRSDIAYKA
KGEEIIHKYN LPADLPQFIQ AKVNAYNISE NIYKADLKDL SKKGYDLRTD AIPIRAAKAA
RQAASDVQYK KDYEKAKGKM VGFQSLQDDP KLVHYMNVAK IQSDREYKKD YEKTKTKYNT
PRDMFNVVAA KKAQDVISNV NYKHSLHHYT YLPDAMDLEL SKNMMQIQSD NVYKEDYNNW
MKGIGWIPIG SLDVEKVKKA GDALNEKKYR QHPDTLKFTS IVDSPVMVQA KQNTKQVSDI
LYKAKGEDVK HKYTMSPDLP QFLQAKCNAY NISDVCYKRD WHDLIAKGNN VLGDAIPITA
AKASRNIASD YKYKEAYEKS KGKHVGFRSL QDDPKLVHYM NVAKMQSDRE YKKNYENTKT
SYHTPGDMVS ITAAKMAQDV ATNVNYKQPL HHYTYLPDAL SLEHTRNVNQ IQSDNVYKDE
YNSFLKGVGW IPIGSLEVEK VKKAGDALNE KKYRQHPDTI KFTSLPDSMG MVLAQHNTKQ
LSDLNYKVEG EKLKHKYTID PELPQFIQAK VNALNMSDAH YKADWKKTIA KGYDLRPDAI
PIVAAKSSRN IASDCKYKEA YEKAKGKQVG FRSLQDDPKL VHYMNVAKIQ SDREYKKGYE
ASKTKYHTPL DMVSVTAAKK SQEVATNANY RQPYHHYTLL PDALNVEHSR NAMQIQSDNL
YKSDFTNWMK GIGWVPIESL EVEKAKKAGE ILSEKKYRQH PEKLKFTYAM DTMEQALNKS
NKLNMDKKLY TEKWNKDKTT IHVMPDTPDI LLSKINQITM SDKLYKAGWE EEKKKGYDLR
PDAIAIKAAR ASRDIASDYK YKQAYEQAKG KHIGFRSLED DPKLVHFMQV AKMQSDREYK
KGYEKSKTSF HTPVDMLSVV AAKKSQEVAT NANYRNVIHT YNMLPDAMSF ELAKTRMQIQ
SDNQYKADYA DFMKGIGWLP LGSLEAEKNK KAMEIISEKK YRQHPDTLKY STLMDSMNMV
LAQNNAKIMN EHLYKQAWEA DKTKVHIMPD IPQIILAKAN AINMSDKLYK LSLEESKKKG
YDLRTDAIPI KAAKASRDIA SDYKYKHDYE KAKGKMVGFR SLEDDPKLVH SMQVAKMQSD
REYKKNYENT KTSYHTPADM LSVTAAKDAQ ANITNTNYKH LIHKYILLPD AMNIELTRNM
NRIQSDNEYK QDYNEWYKGL GWSPAGSLEV EKAKKATEYA SDQKYRQHPS NFQFKKLTDS
MDMVLAKQNA HTMNKYLYTA DWNKDKTNVH VMPDTPDILQ AKQNQTLYSQ KLYKLGWEEA
LKKGYDLPVD AISVQLAKAS RDIASDFKYK QGYRKQLGHH VGFRSLQDDP KLVLSMNVAK
MQSEREYKKD FEKWKTKFSS PVDMLGVVLA KKCQELVSDV DYKNYLHQWT CLPDQNDVVQ
AKKVYELQSE NLYKSDLEWL RGIGWSPLGS LEAEKNKRAS EIISEKKYRQ PPDRNKFTSI
PDAMDIVLAK QILYREAWDK DKTQIHIMPD TPDIVLAKAN LINTSDKLYR MGYEELKRKG
YDLPVDAIPI KAAKASREIA SEYKYKEGFR KQLGHHIGAR NIEDDPKMMW SMHVAKIQSD
REYKKDFEKW KTKFSSPVDM LGVVLAKKCQ TLVSDVDYKN YLHQWTCLPD QSDVIHARQA
YDLQSDNLYK SDLQWLKGIG WMPSGSLEDE KNKRATQILS DHVYRQHPDK FKFSSLMDSI
PMVLAKNNAI TMNHRLYTEA WDKDKTTVHI MPDTPEVLLA KQNKVNYSEK LYKLGLEEAK
RRGYDMRVDA IPIKAAKASR DIASEFKYKE GYRKQLGHHI GARAIHDDPK MMWSMHVAKI
QSDREYKKDF EKWKTKFSSP VDMLGVVLAK KCQTLVSDVD YKNYLHQWTC LPDQSDVIHA
RQAYDLQSDN MYKSDLQWMR GIGWVPIGSL DVEKCKRATE ILSDKIYRQP PDTFKFTSVT
DSLEQVLAKN NAITMNKRLY TEAWDKDKTQ IHIMPDTPEI TLARTNKINY SEVRADSLTF
ARCCLFQLIY CYKYKDGYRK QLGHHIGARN IEDDPKMMWS MHVAKIQSDR EYKKDFEKWK
TKFSSPVDML GVVLAKKCQT LVSDVDYKNY LHQWTCLPDQ SDVIHARQAY DLQSDNIYKS
DLQWLRGIGW VPIGSVDVVK CKRAAEILSD NIYRQPPDKL KFTSVTDSLE QVLAKNNALN
MNKRLYTEAW DKDKTQVHIM PDTPEIMLAR QNKINYSESL YRQAMEEAKK EGYDLRSDAI
PIVAAKASRD IASDYKYKEA YRKQLGHHIG ARAVHDDPKI MWSLHIAKVQ SDREYKKDFE
KYKTRFSSPV DMLGIVLAKK CQTLVSDVDY KHPLHEWICL PDQNDIIHAR KAYDLQSDNL
YKSDLEWMKG IGWVPIDSLE VVRAKRAGEL LSDTIYRQRP ETLKFTSITD SPEQVLAKNN
ALNMNKRLYT EAWDNDKKTI HVMPDTPEIM LAKLNRINYS DKLYKLALEE SKKEGCDLRL
DAIPIQAAKA SREIASDYKY KEGYRKQLGH HIGARNIEDD PKMMWSIHAA KIQSDREYKK
DFEKWKTKFS SPVDMLGMVT AKKCQILVSD VDYRHPLHEW LCLPDQNDVI QARKAYDLQS
DAIYKSDLEW LRGIGWVPIG SVEVEKVKRA GEILSDRKYR QPRDQLKFTC ITDTPEIVLA
KNNALTMSKH LYTEAWDADK TSIHVMPDTP EILLAKSNSA NISQKLYTKG WDESKMKDYD
LRADAISIKS AKASRDIASD YKYKEAYEKQ KGHHIGAQSI EDDPKIMCAI HAGKIQSERE
YKKEFQKWKT KFSSPVDMLG ILLAKKCQTL VSDIDYRNYL HHWTCMPDQN DIIQAKKAYD
LQSDALYKAD LEWLRGIGWM PQGSPEVLRV KNAQEILCDS VYRTPVVNLK YTSIVDTPEV
VLAKSNAENI SIPKYREVWD KDKTSVHIMP DTPEINLARA NALNVSNKLY REGWDEMKAG
CDVRLDAIPI QAAKASREIA SDYKYKLDHE KQKGHYVGTL TARDDNKIRW ALIADKLQNE
REYRLDWAKW KAKIQSPADM LSILHSKNSQ ALVSDVDYRN YLHQWTCMPD QNDVIQAKKA
YELQSDNVYK ADLEWLRGIG WMPNDSVSVN HAKHAADIFS EKKYRTKIET LNFTPVDDRV
DYVTAKQSGE ILDDIKYRKD WNDTKSKYTL TETPLLHTAQ EAARILDQYL YKEGWERQKA
TGYILPPDAV PFVHAHHSSD VQSELKYRAD HVKQKGHYVG VPTMRDDPKL VWFEHAGQIQ
NERLYKEDYH KTKAKINIPA DMKSVLAAKE GQTLVSDIDY RNYLHQWTCH PDQNDVIQAR
KAYDLQSDNI YKADLEWLRG IGWIPLDSVD HVRVTKNQEM MNQIKYKKNA LDNYPNFTSV
VDPPEIVLAK INSVNQSDVK YKETFNKAKG KYTFSPDTPH ISHSRDMGKL YSTILYKGAW
EGTKAYGYTL DERYIPIVGA KHADLVNSEL KYKETYEKQK GHYLAGKVIG EFPGVVHCLD
FQQMRSALNY RKHYEDTKAN VHIPNDMMNH VLAKKCQYIL SDLEYRHYFH QWTSLPEEPN
VIRVRNAQEI LSDNVYKDDL NWLKGIGCYV WDTPQILHAK KSYDLQSQLQ YTAAGKENLQ
NYNLVTDTPV YVTAVQSGIN ASEVKYKENY HQNKDKYTTV LETVDYDRTR NLKNLYSSNL
YKEAWDRVKA TSYILPSSTL SLTHAKNQKH LASRVKYREE YEKFKALYTL PRSVDDDPNT
ARCLRVGKLN IDRLYRSVYE KNKMKIHIVP DMVEMVTAKD SQKKVSEIDY RLHLHEWICH
PDLKVNDHVR KVTDQISDIV YKDDLNWLKG IGCYVWDTPE ILHAKHAYDL RDDIKYKAHM
LKTRNDYKLV TDTPVYVQAV KSGKQLSDAV YHYDYVHSVR GKVAPTTKTV DLDRALHAYK
LQSSNLYKTS LRTLPTGYRL PGDTPHFKHV KDTRYMSSYF KYKEAYEHTK AYGYTLGPKD
VPFVHVRRVN NVTSERLYRE LYHKLKDKIH TTPDTPEIRQ VKKTQEAVSE LIYKSDFFKM
QGHMISLPYT PQVIHCRYVG DITSDIKYKE DLQVLKGFGC FLYDTPDMVR SRHLRKLWSN
YLYTDKARKM RDKYKVVLDT PEYRKVQELK THLSELVYRA AGKKQKSIFT SVPDTPDLLR
AKRGQKLQSQ YLYVELATKE RPHHHAGNQT TALKHAKDVK DMVSEKKYKI QYEKMKDKYT
PVPDTPILIR AKRAYWNASD LRYKETFQKT KGKYHTVKDA LDIVYHRKVT DDISKIKYKE
NYMSQLGIWR SIPDRPEHFH HRAVTDTVSD VKYKEDLTWL KGIGCYAYDT PDFTLAEKNK
TLYSKYKYKE VFERTKSDFK YVADSPINRH FKYATQLMNE KKYRADYEQR KDKYQLVVDE
PRHLLAKTAG DQISQDKFTS IVDTPEHLRT TKVNKQISDI LYKLEYNKAK PRGYTTIHDT
PMLLHVRKVK DEVSDLKYKE VYQRNKSNCT IEPDAVHIKA AKDAYKVNTN LDYKKQYEAN
KAHWKWTPDR PDFLQAAKSS LQQSDFEYKL DREFLKGCKL SVTDDKNTVL ALRNTLIESD
LKYKEKHVKE RGTCHAVPDT PQILLAKTVS HLVSENKYKD YVKKHLAQGS YTTLPETRDT
VHVKEVTKHV SDTNYKKKFV KEKGKSNYSI MLEPPEVKHA MEVAKKQSDV AYRKDAKENL
HYTTVADRPD IKKATQAAKQ ASEVEYRAKH RKEGSHGLSM LGRPDIEMAK KAAKLSSQVK
YRENFDKEKG KTPKYNPKDS QLYKVMKDAN NLASEVKYKA DLKKLHKPVT DMKESLIMNH
VLNTSQLASS YQYKKKYEKS KGHYHTIPDN LEQLHLKEAT ELQSIVKYKE KYEKERGKPM
LDFETPTYIT AKESQQMQSG KEYRKDYEES IKGRNLTGLE VTPALLHVKY ATKIASEKEY
RKDLEESIRG KGLTEMEDTP DMLRAKNATQ ILNEKEYKRD LELEVKGRGL NAMANETPDF
MRARNATDIA SQIKYKQSAE MEKANFTSVV DTPEIIHAQQ VKNLSSQKKY KEDAEKSMSY
YETVLDTPEM QRVRENQKNF SLLQYQCDLK TNFSSVYLLF ILVKQTQDHI KNLSSVFWKG
EKMPLNFRIK LIFMFIFVLY KENMGKGTPF TRHSRDARES RTQSRKILAR GNLVLYKENM
GKGTPLPVTP EMERVKHNQE NISSVLYKEN VGKATPTPVT PEMQRVKRNQ ENISSVLYKE
NLGKATPTPF TPELERVKRN QENFSSVLYK ENMGKATPTP VTPEMERAKR NQENISSVLY
SDSFRKQIQG KAAYVLDTPE MRRVRETQRH ISTVKYHEDF EKHKGCFTPV VTDPITERVK
KNMQDFSDIN YRGIQRKVVE MEQKRNDQDQ ETITGLRVWR TNPGSVFDYD PAEDNIQSRS
LHMINVQAQR RSREQSRSAS ALSISGGEEK SEHSEAPDHH LSTYSDGGVF AVSTAYKHAK
TTELPQQRSS SVGTQQTTVS SIPSHPSTAG KIFRAMYDYM AADADEVSFK DGDAIINVQA
IDEGWMYGTV QRTGRTGMLP ANYVEAI
//
