ID A0A2K6N2H1_RHIBE Unreviewed; 1665 AA.
AC A0A2K6N2H1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=C3 and PZP like alpha-2-macroglobulin domain containing 8 {ECO:0000313|Ensembl:ENSRBIP00000042213.1};
GN Name=CPAMD8 {ECO:0000313|Ensembl:ENSRBIP00000042213.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000042213.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000042213.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000042213.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 61621.ENSRBIP00000042213; -.
DR Ensembl; ENSRBIT00000066256.1; ENSRBIP00000042213.1; ENSRBIG00000044407.1.
DR GeneTree; ENSGT00940000162399; -.
DR OMA; MAWTLPR; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR CDD; cd02897; A2M_2; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR022041; Methyltransf_FA.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF139; C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF12248; Methyltransf_FA; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1665
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014450213"
FT DOMAIN 1561..1605
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1389..1423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1625..1665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1409..1423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1665 AA; 182679 MW; DCFD26108C3AB0A6 CRC64;
MQGGPAMVWR CHMPLFFLLV LISIFTVSPD LRPVNEKLEA YIQDPRGSRM IEWRHLKPFC
CGITNLSFPL SDQPVLGEWF IFVEMQGHAY NKSFEVQKYV LPKFELLIDP PRYIRDLDAC
ETGTVWARYT FGKPVAGVLT INMTVNGVGY YSHEVGRPVL RTTKILGSQD FDICVRDMIP
ADVPEHFRGR VSIWATVTSV DGSQQVAFDD STPVQRQLVD IRYSKDTRKQ FKPGLAYVGK
VELSYPDGSP AEGVTVQIKA ELTPKDNIYT SEAVSQGGLV GFEIPSIPTS AQHVWLETKV
TTLNGKPVGA QYLPSYLSLG SWYSPSQCYL QLQPPSHPLQ VGEEADFSVK STCPCNFTLY
YEVAARGNIV LSGQQPAHIT QQRSKRAAPA LEKPIRLTHL SETEPPPAPA AEVNVCVTSL
RLAVTPSMVP LGRLLVFYVR ENGEGVADSL QFAVETFFEN QVSVTYSANE TQPGEVVDLR
IRAARGSCVC VAAVDKSVYL LRSGFRLTPA QVFQELEDYD VSDSFGVSRE DGPFWWAGLM
AQRRRRSSVF PWPWGITKDS GFAFTETGLV VMTDRVSLNH RQDGGLYTDE AVPAFQPHTG
SLVAAAPSRN PPRTEKRKRT FFPETWIWYC LNISDPSGEE TLSVKVPDSI TSWVGEATAL
STSQGLGIAE PSLLKTFKPF FVDFTLPRLI IRGEQVKIPL SVYNYMGICA EVYMKLSVPK
GIQFVGHPGK SHLTKKMCVA PGEAEPVWVV LSFSDLGLNN ITAKALAYGD TNCCRDGRSS
KHPEENHADK RVPIGVDHVR HSVMVEAEGV PRAYTYSAFF CPSERVHIST PNKYEFQYVQ
WPLHLTRFDV AVRAHNDARV ALSSGPQDTA GMIEIVLGGH QNTRSWISTS KMGEPVASAH
TAKILSWDEF RTFWISWHGG RIQVGHGPEP SNESVIVAWT LPRPPEVQFI GFSTGWGSMG
EFRIWRKMEV DESYSEAFTL GVPHGAIPGS ERAAASIIGD VMGPTLNHLN NLLRLPFGCG
EQNMIHFAPN IFVLKYLQKT QQLSPEVERE TTDYLVQGYQ RQLTYKRQDG SYSAFGERDA
SGSMWLTAFV LKSFAQARSF IFVDPRELVA SKSWIIQQQQ ADGSFPAMGR VLNKDIQGGI
HGTVPLTAYV VAALLETGTA SEEERGSIDK ARHFLESAAP LATDPYSCAL TTYALTLLRS
PAAPEALRKL RSLAIMRDGV THWSLTNSWD MDKGTLLSFG DRTSQSVVSA EVEMTAYALL
TYTLLGDVAA ALPVVKWLSQ QRNALGGFSS TQDTCVALQA LAEYAILSYA GGINLTVSVA
STNLDYQETF ELHRTNQRVL QMAAIPSLPT GLFVSAKGDG CCLMQIDVTY NVPDPVAKPA
FQLLVSLQEP EAQGRPSPMP SSSAEGSRGD RPPADDDDPA ADQHHQEYKV MLEVCTRWLH
AGSSNMAVLE VPLLSGFRAD IESLEQIPSR CLTCVRFRAL RECVVGRTSA LPVSVYDYYE
PAFEATRFYN VSAHSPLAQE LCAGPACNEV ERAPARGPGW SPGESGPGVA PEEGAAITRC
GCDHDCGAQG DPVCGSDGVV YASACRLREA ACRRATPLEP APPNCCALEQ PLPASVSSTY
GDDLASVAPG HLQQDMKLSG AGLEVVDSDP EPEGEVEDSQ SGFSS
//