ID   A0A2K6N4R1_RHIBE        Unreviewed;      1345 AA.
AC   A0A2K6N4R1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|Ensembl:ENSRBIP00000043024.1};
GN   Name=ARHGEF10 {ECO:0000313|Ensembl:ENSRBIP00000043024.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000043024.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000043024.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000043024.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSRBIT00000067067.1; ENSRBIP00000043024.1; ENSRBIG00000044722.1.
DR   GeneTree; ENSGT00940000153798; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR   Pfam; PF19057; PH_19; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          404..591
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          169..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1202..1273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          287..338
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          574..605
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1202..1224
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1246..1271
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1345 AA;  148764 MW;  D5F7704CFC60FD28 CRC64;
     SGPPQPLPQL PAAELENEMK YDTNNNEEEE GEQFDFDSGD EIPEADRQAP SAPETGGAGA
     SEAPAPTGEF PGGSPGGAGA ETTPAVEAAK LVLPMKVNPY SVIDITPFQE DQPPAPAPST
     EEESVGLHVP CGYSVPVPCG YAVPSNLPLL LPAYSSPVII RAMSLDEEET AEVMEDRQPN
     SLSSEEPPNS EDQVSREDSA LARWAADPAN TAWMENPEEA IYDDVPRENS DSEPDEMIYD
     DVENGDEGGN SSLEYGWSSS EFESYEEQSD SECKNGIPRS FLRSNHKKQL SHDLTRLKEH
     YEKKMRELMA STVGAVEIQQ LRQKHELKMQ KLVKAAKDGT KDGLERTRAA VKRGRSFIRT
     KSLIAQDHRS SLEEEQNLFI DVDCKHPEAI LTPMPEGLSQ QQVVRRYILG SVVDSEKNYV
     DALKRILEQY EKPLSEMEPK FLSERKLKTV FYRVKEILQC HSLFQIALAS RVSEWDSVEM
     IGDVFVASFS KSMVLDAYSE YVNNFSTAVA VLKKTCATKP AFLEFLKQEQ EASPDRTTLY
     SLMMKPIQRF PQFILLLQDM LKNTSKGHPD RLPLQMALTE LETLAEKLNE RKRDADQRCE
     VKQIAKAINE RYLNKLLSSG SRYLIRSDDM IETVYNDRGE IVKTKERRVF MLNDVLMCAT
     VSSRASHDSR VMSSQRYLLK WSVPLGHVDA IEYGSSPGAG EHSRHLAVHP PESLAVVANA
     KPNKVYMGPG QLYQDLQNLL HDLNVIGQIT QLIGNLKGNY QNLNQSVAHD WTSGLQRLIL
     KKEDEIRAAD CCRIQLQLPG KQDKSGRPTF FTAVFNTFTP AIKESWVNSL QMAKLALEEE
     NHMGWFCVED DGNHIKKEKH PLLVGHMPVM VAKQQEFKVP AYYGSPHMLI FFFPPNSLIQ
     IGSCTHQMGQ IAIVSFQNST PKVIECFNVE SRILCMLYIP VEEKRREPGA PLDPETSAVR
     ASEVPTICVG TEEGSISIYK SSQGSKKVRL QHFFTPEKST VMSLACTSQS LYAGLVNGAV
     ASYARAPDGS WDSEPQKVIK LGVLPVRSLL MMEDTLWAAS GGQVFIISVE THAVEGQLEA
     HQEEGMVISH MAVAGVGIWI AFTSGSTLRL FHTETLKHLQ DINIATPVHN MLPGHQRLSV
     TSLLVCHGLL MVGTSLGVLV ALPVPRLQGI PKVTGRGMVS YHAHNGPVKF IILATALHEK
     DKDKSGDSLA PGPEPQDEDQ KDALPSEGTG SSLSQGDPDT AIWLGDSLGS MTQKSDMSSS
     SGSLSLSHGS SSLEHRSEDS TIYDLLKDPV SLRSKARRAK KAKASSALVV CGGQGHRRVH
     RKARQPHQEE LAPSVMVWQI PLLNI
//