ID A0A2K6N5L0_RHIBE Unreviewed; 430 AA.
AC A0A2K6N5L0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Homeobox D3 {ECO:0000313|Ensembl:ENSRBIP00000043310.1};
GN Name=HOXD3 {ECO:0000313|Ensembl:ENSRBIP00000043310.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000043310.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000043310.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000043310.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family.
CC {ECO:0000256|ARBA:ARBA00009107}.
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DR RefSeq; XP_017723790.1; XM_017868301.1.
DR RefSeq; XP_017723791.1; XM_017868302.1.
DR RefSeq; XP_017723792.1; XM_017868303.1.
DR RefSeq; XP_017723793.1; XM_017868304.1.
DR RefSeq; XP_017723794.1; XM_017868305.1.
DR RefSeq; XP_017723795.1; XM_017868306.1.
DR AlphaFoldDB; A0A2K6N5L0; -.
DR STRING; 61621.ENSRBIP00000043310; -.
DR Ensembl; ENSRBIT00000067358.1; ENSRBIP00000043310.1; ENSRBIG00000044829.1.
DR GeneID; 108527146; -.
DR KEGG; rbb:108527146; -.
DR CTD; 3232; -.
DR GeneTree; ENSGT00940000160027; -.
DR OMA; YPYGAAH; -.
DR OrthoDB; 728401at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0016235; C:aggresome; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR025281; DUF4074.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45664:SF5; HOMEOBOX PROTEIN HOX-D3; 1.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF13293; DUF4074; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 190..250
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 192..251
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 74..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..134
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 45600 MW; D83DF91D625F976E CRC64;
MLFEQDQQAL ELPECTMQKA AYYENPGLFG GYGYSKTTDT YGYSNPHQSY PPPAAANSLD
TDYPGSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNGQG GGGGSQPPGL NSEQQPPQPP
PPPPTLPPSS PTNPGGGVPA KKPKGGPNSS SATISKQIFP WMKESRQNSK QKNSCATAGE
SCEDKSPPGP ASKRVRTAYT SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF
QNRRMKYKKD QKAKGILHSP AGQSPERSPP LGGAAGHVAY SGQLPPVPGL AYDAPSPPAF
AKSQPNMYGL AAYTAPLSSC LPQQKRYAAP EFEPHPMASN GGGFASANLQ GSPVYVGGNF
VESMAPASGP VFNLGHLSHP SSASVDYSCA AQIPGNHHHG PCDPHPTYTD LSAHHSSQGR
LPEAPKLTHL
//
