ID   A0A2K6N856_RHIRO        Unreviewed;       681 AA.
AC   A0A2K6N856;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=glutamine--fructose-6-phosphate transaminase (isomerizing) {ECO:0000256|ARBA:ARBA00012916};
DE            EC=2.6.1.16 {ECO:0000256|ARBA:ARBA00012916};
GN   Name=GFPT2 {ECO:0000313|Ensembl:ENSRROP00000000455.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000000455.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000000455.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-
CC         phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00001031};
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-
CC       glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-
CC       fructose 6-phosphate: step 1/1. {ECO:0000256|ARBA:ARBA00004775}.
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DR   AlphaFoldDB; A0A2K6N856; -.
DR   Ensembl; ENSRROT00000001845.1; ENSRROP00000000455.1; ENSRROG00000000994.1.
DR   GeneTree; ENSGT00940000156413; -.
DR   UniPathway; UPA00113; UER00528.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00714; GFAT; 1.
DR   CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR   CDD; cd05009; SIS_GlmS_GlmD_2; 1.
DR   Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR   InterPro; IPR017932; GATase_2_dom.
DR   InterPro; IPR005855; GFAT.
DR   InterPro; IPR047084; GFAT_N.
DR   InterPro; IPR035466; GlmS/AgaS_SIS.
DR   InterPro; IPR035490; GlmS/FrlB_SIS.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   NCBIfam; TIGR01135; glmS; 1.
DR   PANTHER; PTHR10937; GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING; 1.
DR   PANTHER; PTHR10937:SF10; GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 2; 1.
DR   Pfam; PF13522; GATase_6; 1.
DR   Pfam; PF01380; SIS; 2.
DR   SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR   SUPFAM; SSF53697; SIS domain; 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
DR   PROSITE; PS51464; SIS; 2.
PE   4: Predicted;
KW   Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1..287
FT                   /note="Glutamine amidotransferase type-2"
FT                   /evidence="ECO:0000259|PROSITE:PS51278"
FT   DOMAIN          359..498
FT                   /note="SIS"
FT                   /evidence="ECO:0000259|PROSITE:PS51464"
FT   DOMAIN          530..671
FT                   /note="SIS"
FT                   /evidence="ECO:0000259|PROSITE:PS51464"
SQ   SEQUENCE   681 AA;  76893 MW;  6434D6B07DA8FFAF CRC64;
     MRIFAYMNYR VPRTRKEIFE TLIKGLQRLE YRGYDSAGVA IDGNNDDVKE RHIQLVKKRG
     KVKALDEELY KQDSMDLKVE FETHFGIAHT RWATHGVPSA VNSHPQRSDK GNEFVVIHNG
     IITNYKDLRK FLESKGYEFE SETDTETIAK LIKYVFDNRE TEDITFSTLV ERVIQQLEGA
     FALVFKSIHY PGEAVATRRG SPLLIGVRSK YKLSTEQIPI LYRTCTLENV KNICKTRMKR
     LDSSACLHAV GDKAVEFFFA SDASAIIEHT NRVIFLEDDD IAAAADGKLS IHRVKRSASD
     DPSRAIQTLQ MELQQIMKGN FSAFMQKEIF EQPESVFNTM RGRVNFETNT VLLGGLKDHL
     KEIRRCRRLI VIGCGTSYHA AVATRQVLEE LTELPVMVEL ASDFLDRNTP VFRDDVCFFI
     SQSGETADTL LALRYCKDRG ALTVGVTNTV GSSMSRETDC GIHINAGPEI GVASTKAYTS
     QFISLVMFGL MMSEDRISLQ NRRQEIIRGL KSLPELIKEV LSLEEKIHDL ALELYTQRSL
     LVMGRGYNYA TCLEGALKIK EITYMHSEGI LAGELKHGPL ALIDKQMPVI MVIMKDPCFA
     KCQNALQQVT ARQGRPIILC SKDDIESSKF AYKTIELPHT VDCLQGILSV IPLQLLSFHL
     AVLRGYDVDF PRNLAKSVTV E
//