ID A0A2K6NAD8_RHIRO Unreviewed; 1723 AA.
AC A0A2K6NAD8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Polycystin 1 like 3, transient receptor potential channel interacting {ECO:0000313|Ensembl:ENSRROP00000001238.1};
GN Name=PKD1L3 {ECO:0000313|Ensembl:ENSRROP00000001238.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000001238.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000001238.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR STRING; 61622.ENSRROP00000001238; -.
DR Ensembl; ENSRROT00000005427.1; ENSRROP00000001238.1; ENSRROG00000004686.1.
DR GeneTree; ENSGT00940000162813; -.
DR OMA; LYIRTSI; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0050915; P:sensory perception of sour taste; IEA:Ensembl.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000434; PC1.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR PANTHER; PTHR10877:SF136; POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 3; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR PRINTS; PR00500; POLYCYSTIN1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1723
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014371690"
FT TRANSMEM 698..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 902..922
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 942..963
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1151..1174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1186..1215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1454..1473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1493..1516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1537..1562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1582..1604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1611..1628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1640..1669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 742..859
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1701..1723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1723 AA; 194282 MW; 5787057FBADA3E73 CRC64;
MFFKGGSWLW LYIRTSIILG SELNSPGPHR QNNCYQFNRI HCSFEEAEHY CQGQRGFLAD
IWKQEVQDLI RDFLEEGKKW WIGQNVMPLK KHQDEKYPAD VAAHGAPKPP SCTYLSRNVN
RISSKEGKCF LRHYFICQTD GILDRDAHYE RNGNDSHLYQ RPEKTKRGVE IARDKTPPGP
GPLSTSCHHP LPAHLSKTLC HPISPFPSVL QNITSQVTAT SEPSSQPLPV ITQLTTPVSV
THAGQSMAET TSSPKEAAHL NTVTSHLQVS LHNASGQVVD ETAGNFSRAV HGLQAHNKLQ
EACEFLQKLT ALTPRFVKPA QVNLINSLIY LSEELLRIPF LNNSSLDFKV HATVCPFHSC
NDVIKAEEGS WLESKRDTEQ VEDILEMSLA ELGNIGEAFL EQNRSSESSV TLTSSIASLL
LSRQNTSTLP LSSYTLGHPA PVRLGFPSAL ALKELLNQHP GVNVQVTGLA FNPFKDLDHR
NVVGSVGSVL LSANRKLLQV HDLVEDIEIM LWRNISMETH PTSFNMSTDQ LTITVNITSL
EKSLIVSIDP DSPLLMTLYL GFQYQPNCTH FHLNITLPKD KVWQKDEEYT WVLTPEHLQH
GIGTYCIRAV LSESQKGAQQ TPSLVSVITA VTQCYYWESH NQTWSSNGCQ VGPQSTILRT
QCLCNHLTFF ASDFFVVPRT VNVEDTVELF LRVTNNPVGV SLLAGLLGFY VITVVWAWKK
DQADMQKVKV TVLADNDPSA QFHYLIQVYT GYRRRAATTA KVVVTLYGSE GRSEPHHLCD
PQKTVFERGG LDVFLLTTRS PLGDLHSLRL WHDNSGVSPS WYVSQVIVCD MAVKRKWHFL
CNCWLAVDLG DCELDRVFIP VSKRELFSFR HLFSSMIVEK FTQDYLWLSV ATRHPWNQFT
RVQRLSCCMT LLLCNMVINV MFWKINSTTA KRDEQLGPFA VAWSELLISI HTAVILFPIN
LVIGRLFPLI EPQETLPLFP PVQASCLSDA SVEPLSATMV VEELKETVRF LLRRNTYLLS
KCEQPPWSSC DITKLVKLLS SLISSHLEGQ SCHQQTERHL ARVVPENHHH FCCYLRRVLQ
RLKSHLGTLG LTQGHQPCDF LDAASQLQKL QELLETHILP TEQEPSREVT SFAILSSEEG
KKFISNGLSK WLTAVCWLLL GLTSLASAFF TALYSLELSK DQATSWMISI ILSVLQNIFI
SQPGKVVFFT FLYSLMISRM PRLNKEKEQQ TKRILALLAK CSSSVPGSRD KNNPVYVAPA
MNSPTKRPER TLKKKKLFKL TGDILVQILF LTLLMTAICS VKDSNRFYLH QAIWKTFSPR
FSEIKLLQDF YPWANHILLP GLYGDYRGKS AVLKPSHCKY GVQLIFQIPC TTIYEKVKEG
QLVFSDMAVP VGIPRACSVT SVHPGPRGRF PADELHKRLT SKNDSGFSYI MRSAFFTSVS
LESFTSLQMS KKGFAWSVIS QVIYYLLVCY YAFIQGCRLK WQKWRFFTGR RNILDTSIIL
ISFIILGLDM KSISLLRKNM ARYRDDQDRF ISFHEAVKVN SAATHLVGFL VLLATVQLWN
LLRHSPRLRV ISRTLSQAWD EVVGFLLIIL ILLTGYAVAF NLLFGCSISD YRTFFSSAVT
VVGLLMGISH QEEVIDLDPV LGTFLILTSV ILMVLVVINL FVSAILMAFG KERKSLKKEV
ALIDMLLQKL SNLLGISRPQ KTSSEQAATT AMGTDTGVLD ELP
//
