ID A0A2K6NCS7_RHIRO Unreviewed; 1192 AA.
AC A0A2K6NCS7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=WW and C2 domain containing 2 {ECO:0000313|Ensembl:ENSRROP00000002084.1};
GN Name=WWC2 {ECO:0000313|Ensembl:ENSRROP00000002084.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000002084.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000002084.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_010376210.1; XM_010377908.1.
DR AlphaFoldDB; A0A2K6NCS7; -.
DR STRING; 61622.ENSRROP00000002084; -.
DR Ensembl; ENSRROT00000009419.1; ENSRROP00000002084.1; ENSRROG00000008042.1.
DR GeneID; 104673777; -.
DR KEGG; rro:104673777; -.
DR CTD; 80014; -.
DR GeneTree; ENSGT00410000025556; -.
DR OMA; DTDYQYK; -.
DR OrthoDB; 1334597at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0035331; P:negative regulation of hippo signaling; IEA:Ensembl.
DR GO; GO:0046621; P:negative regulation of organ growth; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd08680; C2_Kibra; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037771; C2_WWC.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14791; BOMB/KIRA PROTEINS; 1.
DR PANTHER; PTHR14791:SF26; PROTEIN WWC2; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 10..43
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 57..90
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 697..820
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 258..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 305..419
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 262..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1192 AA; 133670 MW; DD8A429D093348C9 CRC64;
MPRRAGSGQL PLPRGWEEAR DYDGKVFYID HNTRRTSWID PRDRLTKPLS FADCVGDELP
WGWEAGFDPQ IGVYYIDHIN KTTQIEDPRK QWRGEQEKML KDYLSVAQDA LRTQKELYHV
KEQRLALALD EYVRLNDAYK EKSSSRTSLF SGSSSSTKYD PDILKAEIST TRLRVKKLKR
ELSQMKQELL YKEQGFETLQ QIDKKMSGGQ SGYELSEAKA ILTELKSIRK AISSGEKEKQ
DLMQSLAKLQ ERFHLDQNIG RSEPDLRSSP VNSHLSLSRQ TLDAGSQTSI SGDIGVRSRS
NLAEKVRLSL QYEEAKRSMA NLKIELSKLD SEAWPGALDI EKEKLMLINE KEELLKELQF
VTPQKRTQDE LERLEAERQR LEEELLPVRG APSRALAERL RLEERRKELL QKLEETTKLT
TYLHSQLKSL SASTLSMSSG SSLGSLASSR GSLNTSSRGS LNSLSSTELY YSSQSDQIDV
DYQYKLDFLL QEKSGYIPSG PITTILENEV VKSPSQPGQS GLCGVAAAAT GHTPPLAEAP
KSVASLSSRS SLSSLSPPGS PLVLEGTFPL SSHDASLHQF SADFEDCELS SHFADISLVE
NQILLDSDSG GASQSLSEDK DLNECAGEPL YEGTADVEKS LPKRRVIHLL GEKTTCVSAA
VSDESVAGDS GVYEAFVKQP SEIEDVTYSE EDIAIVETAQ VQIGLRYNAK SSSFMVIIAQ
LRNLHAFLIP HTSKVYFRVA VLPSSTDVSC LFRTKVHPPT ESILFNDVFR VAISQTALQQ
KTLRVDLCSV SRHRREECLA GTQISLADLP FPSEVFTLWY NLLPSKQMPC KKNEENEDSV
FQPNQPLGDS IDLDAVSALL ARTSAELLAV EQELAQEEEE EESRQEEQRG PDGDWLTMLR
EASNEIVAKK EAEVKLPEDS NCTEDLSSCT SVPEMNEDGN RKENNCAKDL RSQPPAATPT
LVDKETNTDE AANDNMTVRP KECSSLSSRQ HPFVRSSVIV RSQTFSPGER SQYICRLNRS
DSDSSTLAKK SLFVRNSTER RSLRVKRTVC QSVLRRTAQE CPVRTSLDLE LDLQASLTRQ
SRLNDELQAL RDLRQKLEEL KAQGETDLPP GVLEDERFQK LLKQAEKQAE QSKEEQKQGL
NAEKLMRQVS KDVCRLREQS QKVPRQVQSF REKIAYFTRA KISIPSLPAD DV
//
