ID A0A2K6NCZ6_RHIRO Unreviewed; 374 AA.
AC A0A2K6NCZ6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=NF-kappa-B essential modulator {ECO:0000256|ARBA:ARBA00040893};
DE AltName: Full=IkB kinase-associated protein 1 {ECO:0000256|ARBA:ARBA00041660};
DE AltName: Full=Inhibitor of nuclear factor kappa-B kinase subunit gamma {ECO:0000256|ARBA:ARBA00043239};
DE AltName: Full=NF-kappa-B essential modifier {ECO:0000256|ARBA:ARBA00041525};
GN Name=IKBKG {ECO:0000313|Ensembl:ENSRROP00000002149.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000002149.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000002149.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A2K6NCZ6; -.
DR Ensembl; ENSRROT00000009662.1; ENSRROP00000002149.1; ENSRROG00000008677.1.
DR GeneTree; ENSGT00530000063808; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 2.
DR Gene3D; 1.20.5.990; Nemo cc2-lz domain - 1d5 darpin complex; 1.
DR InterPro; IPR032419; CC2-LZ_dom.
DR InterPro; IPR021063; NEMO_N.
DR PANTHER; PTHR31553; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR PANTHER; PTHR31553:SF3; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR Pfam; PF16516; CC2-LZ; 1.
DR Pfam; PF11577; NEMO; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 44..111
FT /note="NF-kappa-B essential modulator NEMO N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11577"
FT DOMAIN 257..344
FT /note="NF-kappa-B essential modulator NEMO CC2-LZ"
FT /evidence="ECO:0000259|Pfam:PF16516"
FT REGION 15..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 51..353
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 374 AA; 43130 MW; 9D055039094D40B5 CRC64;
MSRHLWKSQL CEMVQPSGGP AADQDVLGEE SPLGKPAMLH LPSEQGAPET LQRCLEENQE
LRDAIRQSNQ MLRERCEELL HFQASQREEK EFLMCKFQEA RKLVERLSLE KLNLKRQKEQ
ALREVEHLKR CQQQMAEDKA SVKAQVTSLL GELQESQSRL EAATKECQTL EGRARAASEQ
ARQLESEREA LQQQHSVQVD QLRMQGQSVE AALRMERQAA SEEKRKLAQL QVAYHQLFQE
YDNHIKSSLV GSERKRGMQL EDLKQQLQQA EEALVAKQEV IDKLKEEAEQ HKIVMETVPV
LKAQADIYKA DFQAERQARE KLAEKKELLQ EQLEQLQREY SKLKASCQES ARIEDMRKRH
VEVSQAPLPP APGE
//
