ID   A0A2K6NDD5_RHIRO        Unreviewed;      2768 AA.
AC   A0A2K6NDD5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Helicase with zinc finger 2 {ECO:0000313|Ensembl:ENSRROP00000002286.1};
GN   Name=HELZ2 {ECO:0000313|Ensembl:ENSRROP00000002286.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000002286.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000002286.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSRROT00000010342.1; ENSRROP00000002286.1; ENSRROG00000009088.1.
DR   GeneTree; ENSGT00940000160694; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR   CDD; cd18076; DEXXQc_HELZ2-N; 1.
DR   CDD; cd18808; SF1_C_Upf1; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR   Pfam; PF13086; AAA_11; 3.
DR   Pfam; PF13087; AAA_12; 2.
DR   Pfam; PF00773; RNB; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT   DOMAIN          143..172
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50103"
FT   ZN_FING         143..172
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT   REGION          1132..1158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2768 AA;  308716 MW;  DF996C7248DCF3C3 CRC64;
     MVGCRPTFPR PLCYQVCRYY SPGLGCRRHR NRCTFARSRE EALVWTFERQ HNLQRMWLKA
     EVQGGGAQGG AGRAADAILT EFGGRFELLC SLCFRCCPPR VCRVDPQGQC PEHGACPSLL
     AHVSAEGRRK QQFVTVRPQP RAGQPPAYCR FVGRGQPCWR GESRCQFAHS AVEMAVWEAE
     QLGGLQRGDL LTPPAPDSDG RTVPLGQPPV AWLYCPACLV TCHSQEAFEN HCASSEHAQM
     VAFDQAVPWE HRSPPPGLSK FELCPKPDLC EYGDACTKAH SARELQEWVQ RRRAVELRGQ
     AAWQGGLVPY QERLLAEYQR SSSEVLVLAE TLDGVLVTCN QPLMYQAQER KTQYSWTFAV
     HSEEPLLHVA LLKQEPGANF SLVAPGLLPG RLYARGERFR LPSSAADFQV GVSVQAASFG
     TFEQWVVFDF GRRPVLLRKL GLQLGQGRRP EPCRSLALGH PEEMERWHTG NRHVVPAVER
     TAEQTALMAK YKDPALALEF NRSGLASGPI SPTNYRQRMH QFLYEEETAQ QQLVAKLTLR
     GQVFLKTALQ TPALNMLFAP PGALYAEVPV PPSLMPDTDQ GFLLGRAVST ALVAPVPAPN
     NAVFEVRLEK RASSEQALWL LLPARCCLAL GLQPEARLVL EVQFQIDPMT FRLWHQAVDT
     LPEEQLVVPD LPACALPRPW SVPPLRRGNR KQELAVALIA GWGPGDGRRV PPLLIYGPFG
     TGKTYTLAMA SLEVIRRPQA KVLICTHTNS AADIYIREYF HSHVSGGHPE ATPLRVMYTD
     RPPSQTDPVT LQYCCLTNDH RAFRPPTWAE LARHRVVVTT TSQARELRVP VGFFSHILLD
     EAAQMLECEA LTPLAYASHS TRLVLAGDHM QVTPRLFSVA RARAAEHTLL HRLFLYYQQE
     THEVARQSRL VFHENYRCTE AIVSFVSRHF YVAKGNPIHA RGKVPPHPRH YPLMFCHVAG
     SPDRDISMTS WLNLAEIAQA VEKVQEVYNT WPSCWGGREQ RHICVVSHGA QVSALRQELR
     RRDLGQVSVG SFEILPGRQF RVVVLSTVHT CQSLLSPGAP APEFFTDARV LNTILTRAQS
     QLVVVGDAVA LCSFGACGKL WESFIRECVE RHSVCPEGLS MEQVEQGVAQ RRRWPPQGTR
     AGAVGNWEAA PEPVGDPAEE PATVVTATVK AEPGDEALSP ASGEITATTA QTEAVAAPAG
     GAVKEDTAPG ACTAGAAAAA GVESTEPEDA EADFWPWDGE LNADDAILRE LLDESQKVMV
     TVGEDGLLDT VARPESPRQA RLYENLPPAA LRKLLRAEPE WYRHCTFVQE TFERASAIPL
     DDASSGPIQV RGRLDCGMAF TGDEVLVQLL SGDRAPEGRL RGRVLGVLKR RRHELAFVCR
     MDRWDPRIMV PINGSVTKIF VAELKDPSQV PVYGLRKGRL QRVGLERLTV EARHSRLFWV
     HIVLWRQGFY YPLGIVREVL PEASTWEQGL RILGLEYSLR VPPSDLAAVT KALQKYQTEL
     GRVAGRREDC RAFLTFTVDP QGACNLDDAL SVRDLGPQCE VAVHITDVAS FVPRDGVLDV
     EARRQGAAFY APGREPVPML PASLCQDILS LLPGRDRLAI SLFLTMEKAS GQLKSLHFAP
     SVVRSDRQLS YEEAEQVIRQ HPGAGRELPA RLDSVDACVV AACYFSRLLR RHRLQSDCFY
     EQPDEDSTLG FRAAHIMVKE YMIQFNRLVA EFLVGSERTR TVTPLRWQPA PHSQQLKALC
     EKHGEWVPLS LHLGHHLRGG GGSAPDTQLH LLASLWKQVQ FAARTQDYEQ MVDLVTTDDM
     HPFLAPASRD LRKALERSAF GRCTWGHQQQ GGHYSLQVEW YTWATSPIRR YLDVVLQRQI
     LLALGHGGSA YSARDIDGLC QGFSLQHALA QSYQRRAHSL HLAVQLKAQP LDKLGFAVDV
     EAGSRCFRLQ FPSNRETLPD PCSVPYSSLQ LAEHPHALAG RPGLQLLWRR RVYSVQGSSP
     PLPLPGTVLD PHTWAVETAL WKQLLALVEL QLWPEAAALI QEKGEASPRR GLVQVQRSRC
     GHFLEVAREL GSGDTLQVQL GASLQHGFLV PSPQLWTVAP GFSLCLEHVE RPGDCFLGHV
     YRAPRDRYRD VDEYACVWEP FCALESATGA VAENDSVTLQ HLSVSWDVSR MPQGQLQGAF
     RLEAAFLEEN CVDINLSCCY LCIRLEGLPA PTASPRPGPS SLGPGLSVDP GTYTWVAHGQ
     TEDWDQERRA DRQEAPRQVH LFIHHMGMEK VPEEVLRPGT LFTVELLPKQ LPDLRKEEAV
     RGLEEASPLV TSIALGQPVP QPLCRVIPSR FLERQTYDIP GGRHKLNPSQ NRAVREALEK
     PLTVVQGPPE LLLRRMELKP LRVYSEQAEA SEFPVPRLGS RKLLRRNPRE GRPNQSLRSI
     TLHHRIRQAP NPYSSEIKAF DTRLQSGELF SREDLVLYKK VLWEARKFEL ERHEVILCTC
     SCAASASLKT LDVRQILVDE AGMATEPETL IPLVRFPQAE KVVLLGDHKQ LRPVVKNEWL
     QNLGLDRSLF ERYHEDAHML DTQYRMHEGI CAFPSVAFYK SRLKTWQGLK RPPSVLGHAG
     KESCPVIFGH VQGHERSLLV STDEGNENSK ANLEEVAEVV RITKQLTLGR TIEPQDVAVL
     TPYNAQASEI SKALRREGIA GVAVSSITKS QGSEWRYVLV STVRTCAKSD LDQRPTKSWL
     KKFLGFVVDP NQVNVAVTRA QEGLCLIGDH LLLRCCPLWR SLLDFCEAQQ SLVPASQVRV
     CRRPTMPS
//