ID A0A2K6NIP4_RHIRO Unreviewed; 2463 AA.
AC A0A2K6NIP4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Centrosomal protein 290 {ECO:0000313|Ensembl:ENSRROP00000004149.1};
GN Name=CEP290 {ECO:0000313|Ensembl:ENSRROP00000004149.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000004149.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000004149.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120}.
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DR Ensembl; ENSRROT00000018683.1; ENSRROP00000004149.1; ENSRROG00000016571.1.
DR GeneTree; ENSGT00730000111039; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR InterPro; IPR032321; Cep209_CC5.
DR InterPro; IPR026201; Cep290.
DR PANTHER; PTHR18879; CENTROSOMAL PROTEIN OF 290 KDA; 1.
DR PANTHER; PTHR18879:SF20; CENTROSOMAL PROTEIN OF 290 KDA; 1.
DR Pfam; PF16574; CEP209_CC5; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 1273..1400
FT /note="Centrosomal protein of 290kDa coiled-coil region"
FT /evidence="ECO:0000259|Pfam:PF16574"
FT REGION 2444..2463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 66..422
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 447..488
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 519..549
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 586..648
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 682..737
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 765..848
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 946..1011
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1057..1091
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1122..1170
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1205..1232
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1274..1383
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1451..1478
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1526..1563
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1625..1919
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1961..2019
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2056..2435
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2463 AA; 288391 MW; 1C5398FCF3054139 CRC64;
MPPNINWKEI MKVDPDDLPR QEELADNLLI SLSKVIKYKT VVEVNELKSE KQENVIHLFR
ITQSLMKMKA QEVELALEEV EKAGEEQMAQ QSAGGRDTRF LRDEIRQLAK QLEQKDRELE
DIEKELEKEK KVNEQLALRN EEAENENSKL RRENEQLCQD IIDYQKQIDS QKETLLSRRG
EDSDYRSQLS KKNYELVQYL DEIQTLTEAN EKIEVQNQEM RKNLEESVQE MEKMTDEYNR
MKAIVHQTDN VIDQLKKEND HYRLQVQELT DLLKAKNEED DPIMVAVNAK VEEWKLILSS
KDDEIIEYQQ MLHNLREKLK NAQLDADKSN VMALQQGIQE RDSQIKMLTE QVEQYTKEME
KNTFIIEDLK NELQRDKGAS TLSQQTHYMK IQSTLDILKE KTKEAERTAE LAEADAREKD
KELVETLKRL KDYESGVYGL EDAVIEIKNC KNQIKIRDRE IEILTKEINK LELKINDFLD
ENEALRERVG LEPKTMIDLT EFRNSKHLKQ QQYRAENQIL LKEASIESLE EERLDLKKKI
RQMAQERGKR SATSGLTTED LNLTENVSQG DRISERKLDL LSLKNMSEAQ SKNEFLSREL
IEKERDLERS RTVIAKFQNK LKELVEENKQ LEEGMKEILQ AIKEMQKDPD VNGGETSLII
PSLERLVNAI ESKNAEGIFD ASLHLKAQVD QLTGRNEELR QELRESRKEA INYSQQLAKA
NLKIDHLEKE TSLLRQSEGS NVVFKGIDLP DGIAPSSASI INSQNEYLIH LLQELENKEK
KLKNLEDSLE DYNRKFAVIR HQQSLLYKEY LSEKDTWKTE SKTIKEEKRK LEDQIQQDAI
KVKEYNNLLN TLQMDSDEMK KILAENSRKI TVLQVNEKSL IRQYTISVEL ERQLRKENEK
QKNELLSMEA EVCEKLGCLQ RFKEMAIFKI AALQKVVDNS VCLSELELAN KQYNELTSKY
RDILQKDNML VQRTSNLEHL ECENASLKEQ LESINKELEI TKEKLHTIEQ AWEQETRLGN
ESSMDKAKKS ITNSDIVSIS KKITMLEMKE LNERQRAEHC QKMYEHLRTS LKQMEERNFE
LETKFAELTK INLDAQKVEQ MLRDELAGSV SKAVSDADRQ RILELEKNEM ELKVEVSKLR
EISDIARRQV EILNAQQQSR EKEVESLRMQ LLDYQAQSDE KALIAKLHQH NVSLQLSEAT
ALGKLESITS KLQKTEAYNL RLEQKLDEKE QALYYARLEG RNRAKHLRQT IQSLRRQFSG
ALPLAQQEKF SKTMIQLQND KLKIMQEMKN SQQEHRNMEN KTLEMELKLK GLEELISTLK
DTKGAQKVIN WHMKIEELRL QELKLNRELV KDKEEIKYLN NIISEYERTI SSLEEEIVQQ
NKFHEERQMT WDQREVDLER QLDIFDRQQN EILNAAQKFE EATGSIPDPS LPLPNQLEMA
LRKIKENIRI ILETRATCRS LEEKLKEKES ALRLAEQNIL SRDKVINELR LRLPATAERE
KLIAELGRKE MEPKSHHTLK IAHQTIANMQ ARLNHKEEVL KKYQHLLEKA REEQREIVKK
HEEDLHILHH KLELQADSSL NKFKQTAWDL MKQSPPPVPT NKHFIRLAEM EQTVAEQDDS
LSSLLIKLKK VSQDLERQRE ITELKVKEFE NIKLRLQENH EDEVKKVKAE VEDLRYLLDQ
SQKESQCLKS ELQAQKEANS RAPTTTMRNL VERLKSQLAL KEKQQKALSR ALLELRAEMT
AAAEERIISA TSQKEAHLNV QQIVDRHTRE LKTQVEDLNE NLLKLKEALK TSKNRENSLT
DNLNDLNNEL QKKQKAYNKI LREKDEIDQE NDELKRQIKR LTSGLQGKPL IDNKQSLIEE
LQRKIKKLES QLEGKVDEVD LKPMKEKNAK EELIRWEEGK KWQAKIEGIR NKLKEKEGEV
FTLTKQLNTL KDLFAKADKE KLTLQRKLKT TGMTVDQVLG VRALESEKEL EELKKRNLDL
ENDILYMRAH QALPRDSVVE DLHLQNRYLQ EKLHALEKQL SKDTYSRPSI SGIESDDHCQ
REQELQKENL KLSSENIELK FQLEQANKDL PRLKNQVRDL KEMCEFLKKE KAEVERKLGH
VRGSGRSGKT IPELEKTIGL MKKVVEKVQR ENEQLKKASG ILTSEKMANI EQENEKLKAE
LEKLKAHFGH QLSMHYESKT KGTEKIIAEN EKLRKELKKE TDAAEKLRIA KNNLEILNEK
MTVQLEETGK RLQFAESRGP QLEGADSKSW KSIVVTRMYE TKLKELETDI AKKNQSITDL
KQLVKEATER EQKVKKYTED LEEQIKILKH VPEGAETEQG LKRELQVLRL ANSQLDKEKA
ELIHQIEANK DQSGAESTIP DADQLKEKVK DLETQLKMSD QEKQHLKEEI KKLKKELENF
DPSFFEEIED LKYNYKEEVK KNILLEEKVK KLSEQLGVEL TSPVAASEEF EDDEESPVNF
PIY
//
