ID A0A2K6NQB6_RHIRO Unreviewed; 104 AA.
AC A0A2K6NQB6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=SOSS complex subunit C {ECO:0000256|ARBA:ARBA00014540, ECO:0000256|RuleBase:RU369016};
DE Short=SOSS-C {ECO:0000256|RuleBase:RU369016};
DE Short=SSB-interacting protein 1 {ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Sensor of single-strand DNA complex subunit C {ECO:0000256|ARBA:ARBA00030383, ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Sensor of ssDNA subunit C {ECO:0000256|ARBA:ARBA00033066, ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Single-stranded DNA-binding protein-interacting protein 1 {ECO:0000256|ARBA:ARBA00031967, ECO:0000256|RuleBase:RU369016};
GN Name=INIP {ECO:0000313|Ensembl:ENSRROP00000006463.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000006463.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000006463.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC functions downstream of the MRN complex to promote DNA repair and G2/M
CC checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC lesions and influences diverse endpoints in the cellular DNA damage
CC response including cell-cycle checkpoint activation, recombinational
CC repair and maintenance of genomic stability. Required for efficient
CC homologous recombination-dependent repair of double-strand breaks
CC (DSBs). {ECO:0000256|RuleBase:RU369016}.
CC -!- SUBUNIT: Component of the SOSS complex.
CC {ECO:0000256|RuleBase:RU369016}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369016}.
CC -!- SIMILARITY: Belongs to the SOSS-C family.
CC {ECO:0000256|ARBA:ARBA00007829, ECO:0000256|RuleBase:RU369016}.
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DR RefSeq; XP_010368742.1; XM_010370440.1.
DR RefSeq; XP_010368743.1; XM_010370441.1.
DR AlphaFoldDB; A0A2K6NQB6; -.
DR SMR; A0A2K6NQB6; -.
DR STRING; 61622.ENSRROP00000006463; -.
DR Ensembl; ENSRROT00000028446.1; ENSRROP00000006463.1; ENSRROG00000025528.1.
DR GeneID; 104667859; -.
DR KEGG; rro:104667859; -.
DR CTD; 58493; -.
DR GeneTree; ENSGT00390000006366; -.
DR OMA; MTSNPPG; -.
DR OrthoDB; 2913067at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0070876; C:SOSS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0044818; P:mitotic G2/M transition checkpoint; IEA:Ensembl.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:UniProtKB-UniRule.
DR InterPro; IPR031821; SOSSC.
DR PANTHER; PTHR31526; SOSS COMPLEX SUBUNIT C; 1.
DR PANTHER; PTHR31526:SF2; SOSS COMPLEX SUBUNIT C; 1.
DR Pfam; PF15925; SOSSC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU369016};
KW DNA repair {ECO:0000256|RuleBase:RU369016};
KW Nucleus {ECO:0000256|RuleBase:RU369016};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
SQ SEQUENCE 104 AA; 11425 MW; 87B2467920C58C1E CRC64;
MAANSSGQGF QNKNRVAILA ELDKEKRKLL MQNQSSTNHP GASIALSRPS LNKDFRDHAE
QQHIAAQQKA ALQHAHAHSS GYFITQDSAF GNLILPVLPR LDPE
//
