ID A0A2K6NQM8_RHIRO Unreviewed; 1397 AA.
AC A0A2K6NQM8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN Name=POLR3A {ECO:0000313|Ensembl:ENSRROP00000006584.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000006584.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000006584.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|RuleBase:RU004279};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
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DR STRING; 61622.ENSRROP00000006584; -.
DR Ensembl; ENSRROT00000028790.1; ENSRROP00000006584.1; ENSRROG00000025527.1.
DR GeneTree; ENSGT00930000151028; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0071667; F:DNA/RNA hybrid binding; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0042797; P:tRNA transcription by RNA polymerase III; IEA:Ensembl.
DR CDD; cd02736; RNAP_III_Rpc1_C; 1.
DR CDD; cd02583; RNAP_III_RPC1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR035698; RNAP_III_Rpc1_C.
DR InterPro; IPR035697; RNAP_III_RPC1_N.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF32; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 248..559
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
SQ SEQUENCE 1397 AA; 156031 MW; 4FC41C4F961E04F3 CRC64;
MVKEQFRETD VAKKISHICF GMKSPEEMRQ QAHIQVVSKN LYSQDNQHAP LLYGVLDHRM
GTSEKDRPCE TCGKNLADCL GHYGYIDLEL PCFHVGYFRA VIGILQMICK TCCHIMLSQE
EKKQFLDYLK RPGLTYLQKR GLKKKISDKC RKKNICHHCG AFNGTVKKCG LLKIIHEKYK
TNKKVVDPIV SNFLQSFETA IEHNKEVEPL LGRAQENLNP LVVLNLFKRI PAEDVPLLLM
NPEAGKPSDL ILTRLLVPPL CIRPSVVSDL KSGTNEDDLT MKLTEIIFLN DVIKKHRISG
AKTQMIMEDW DFLQLQCALY INSELSGIPL NMAPKKWTRG FPQSLCSYYS HQHMVCRFRG
NLSGKRVDFS GRTVISPDPN LRIDEVAVPV HVAKILTFPE KVNKANISFL RKLVQNGPEV
HPGANFIQQR HTQMKRFLKY GNREKMAQEL KYGDIVERHL IDGDVVLFNR QPSLHKLSIM
AHLARVKPHR TFRFNECVCT PYNADFDGDE MNLHLPQTEE AKAEALVLMG TKANLVTPRN
GEPLIAAIQD FLTGAYLLTL KDTFFDRAKA CQIIASILVG KDEKIKVRLP PPTILKVCAG
AVFSGTVLVP GSSPSDDNPV RANLRTKGKQ YSGKGEDLCA NDSYVTIQNS ELMSGSMDKG
TLGSGSKNNI FYILLRDWGQ NEAADAMSRL ARLAPVYLSN RGFSIGIGDV TPGQGLLKAK
YELLNAGYKK CDEYIEALNT GKLQQQPGCT AEETLEALIL KELSVIRDHA GSACLRELDK
SNSPLTMALC GSKGSFINIS QMIACVGQQA ISGSRVPDGF ENRSLPHFEK HSKLPAAKGF
VANSFYSGLT PTEFFFHTMA GREGLVDTAV KTAETGYMQR RLVKSLEDLC SQYDLTVRSS
TGDIIQFIYG GDGLDPAAME GKDEPLEFKR VLDNIKAVFP CPSEPALSKN ELILTTESIT
KKSEFLCCQD SFLQEIKKFI KGVSEKIKKT RDKYGINDNG TTEPRVLYQL DRITPTQVEK
FLETCRDKYM RAQMEPGSAV GALCAQSIGE PGTQMTLKTF HFAGVASMNI TLGVPRIKEI
INASKAISTP IITAQLDKDD DADYARLVKG RIEKTLLGEI SEYIEEVFLP DDCFILVKLS
LERIRLLRLE VNAETVRYSI CTSKLRVKPG DVAVHGEAVV CVTPRENSKS SMYYVLQFLK
EDLPKVVVQG IPEVSRAVIH IDEQSGKEKY KLLVEGDNLR AVMATHGVKG TRTTSNNTYE
VEKTLGIEAA RTTIINEIQY TMVNHGMSID RRHVMLLSDL MTYKGEVLGI TRFGLAKMKE
SVLMLASFEK TADHLFDAAY FGQKDSVCGV SECIIMGIPM NIGTGLFKLL HKADRDPNPP
KRPLIFDTNE FHIPLVT
//
