ID A0A2K6NR43_RHIRO Unreviewed; 5599 AA.
AC A0A2K6NR43;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN Name=MDN1 {ECO:0000313|Ensembl:ENSRROP00000006745.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000006745.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000006745.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR RefSeq; XP_010356063.1; XM_010357761.1.
DR STRING; 61622.ENSRROP00000006745; -.
DR Ensembl; ENSRROT00000029364.1; ENSRROP00000006745.1; ENSRROG00000026180.1.
DR GeneTree; ENSGT00550000074802; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd01460; vWA_midasin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 7.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 2.
DR SMART; SM00382; AAA; 6.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 5387..5586
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 517..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3989..4011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4697..5207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5235..5264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4697..4740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4755..4778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4779..4811
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4817..4893
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4907..4932
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4942..4956
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4963..4987
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5079..5094
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5104..5130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5599 AA; 633258 MW; E9D2F6D19919957B CRC64;
MEHFLLEVAA APLQLIAAKN EKSRSELGRF LAKQVWTSQD RQCVLSTLAQ LLLDKDCTVL
VGRQLRPLLL DLLERNAEAI KAGGQINHDL HERLCVSMSK LIGNHPDVLP FALRYFKDTS
PVFQRLFLES SDANPVRYGR RRMKLRDLME AAYKFLQQEQ SVFRELWDWS VCVPLLRSHD
TLVRWYTANC LALVTCMNEE HKLSFLKKIF NSDELIHFRL RLLEEAQLQD LEKALVLANP
EASLWCKEKE LQYLQGHLVS SDLSPRVTAV CGVVLPGQPP APGELGGDRS SSREQELALR
SYVLVESVCK NLQTLAMAVA SQNAVLLEGP IGCGKTSLVE YLAAMTGRTK PPQLLKVQLG
DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATMGHWILL EDIDYAPLDV VSVLIPLLEN
GDLLIPGRGD CLKVASGFQF FATRRLLSCG GNWYRPLNSH ATLLDKYWTK IHLDNLDKRE
LNEVLQSRYP SLLAVVDHLL DIYIQLTGEK HHSWSDSSVG CEQAPEEVSE ARRENKRPTL
EGRELSLRDL LNWCNRIAHS FDSSSLSASL NIFQEALDCF TAMLSEHMSK LKMAEVIGSK
LNISRKKAEF FCQLYKPEIV INELDLQVGR VRLLRKQSEA VHMQREKFTF AATRPSSVLI
EQLAVCVSKG EPVLLVGETG TGKTSTVQYL AHITGHRLRV VNMNQQSDTA DLLGGYKPVD
HKLIWLPLRE AFEELFAQTF SKKQNFTFLG HIQTCYRQKR WHDLLRLMQH VHKSAVNKDG
KESETGLLIK EKWEAFGLRL NHAQQQMKMT ENTLLFAFVE GTLAQAVKKG EWILLDEINL
AAPEILECLS GLLEGSSGSL VLLDRGDTEP LVRHPDFRLF ACMNPATDVG KRNLPPGIRN
RFTELYVEEL ESKEDLQVLI VDYLKGLSVN KNTVQGIINF YTALRKESGT KLVDGTGHRP
HYSLRTLCRA LRFAASNPCG NIQRSLYEGF CLGFLTQLDR ASHPIVQKLI CQHVVSGNVK
SLLKQPIPEP KGGRLIQVEG YWIVVGDKEP TIDETYILTS SVKLNLRDIV RVVSAGTYPV
LIQGETSVGK TSLIQWLAAA TGNHCVRINN HEHTDIQEYI GCYTSDSSGK LVFKEGVLID
AMRKGYWIIL DELNLAPTDV LEALNRLLDD NRELLVTETQ EVVKAHPRFM LFATQNPPGL
YGGRKVLSRA FRNRFVELHF DELPSSELET ILHKRCSLPP SYCSKLVKVM LDLQSYRRSS
SVFAGKQGFI TLRDLFRWAE RYRLAEPTEK EYDWLQHLAN DGYMLLAGRV RKQEEVDVIQ
EVLEKHFKKK LCPQSLFSKE NVVKLLGKLS TEISTLESNF GHIVWTEGMR RLAMLVGRAL
EFGEPVLLVG DTGCGKTTIC QVFASLANQK LYSVSCHLHM ETSDFLGGLR PVRQKPNDKE
EIDTSRLFEW HDGPLVQAMK EDGFFLLDEI SLADDSVLER LNSVLEVEKS LVLAEKGSPE
DKDSEVELLT AGKKFRILAT MNPGGDFGKK ELSPALRNRF TEIWCPQSTS REDLIQIINH
NLRPGLCLGR IDPKGSDIPE VMLDFIDWLT HQEFGRKCMV SIRDILSWVN FMNKMGEEAA
SKRPETISTV TSFVHAACLV YIDGIGSGVT SSGFGTALLA RKECLKFLVK RLAKIVRLTE
YQKNELKIYD RMKAKEFTGI DNLWGIHPFF IPRGPVLHRN NIADYALSAG TTAMNAQRLL
RATKLKKPIL LEGSPGVGKT SLVGALAKAS GNTLVRINLS EQTDITDLFG ADLPVEGGKG
GEFAWRDGPL LAALKAGHWV VLDELNLASQ SVLEGLNACF DHRGEIYVPE LGMSFQVQHE
KTKIFGCQNP FRQGGGRKGL PRSFLNRFTQ VFVDPLTVID MEFIASTLFP AIEKNIVKKM
VAFNNQIDHE VTVEKKWGQK GGPWEFNLRD LFRWCQLMLV DQSPGCYDPG QHVFLVYGER
MRTEEDKKKV IAVFKDVFGS NSNPYMGTRL FRITPYDVQL GYSVLSRGNC VPHPSRHPLL
LLHQSFQPLE SIMKCVQMSW MVILVGPASV GKTSLVQLLA HLTGHTLKIM AMNSAMDTTE
LLGGFEQVDL TRPWRQLLEK VEGTVRALLR DSLLISADDA EVVLRAWSHF LLTYKPKCLG
EGGKAITMEI VNKLEAVLLL MQRLNNKINS YSKAEFAKLV EEFRSFGVKL TQSASGRSHG
TFEWVDSMLV QALKSGDWLL MDNVNFCNPS VLDRLNALLE PGGVLTVSER GMIDGSTPTI
TPNPNFRLFL SMDPVHGDIS RAMRNRGLEI YISGEGDVST PDNLDLKVLL HSLGLVGNSV
CDILLALHTQ TRSTVVGSPT SSVSTLIRTA ILIVQYLQRG LSLDRAFSEA CWEVYVCSQH
SPANRKLVQA LLEKHVSSLR AHETWGDSIL GMGLWPDSVP SALFATEDSH LSTVRSDGQI
LAYCLNRMSM KTSSWTRSQP LTLQDLEKIM QSSSPENLKF NAVEVNTYWI DEPDVLAMAV
KLLIERATNQ DWMLRVKWLY HLAKNIPQGL ESIQIHLEAS AASLRNFYSH SLSGAVSNVF
KILQPNTTDE FVIPLDPRWN MQALDMIRNL MDFDPQTDQP DQLFALLESA ANKTIIYLDR
EKRVFTEANL VSVGSKKLRD SVLRMSFEFH QDPESYHTLP HEIVVNLAAF FELCDALVLL
WVQSSQGVVS DAIVYEILGS LRWRDRFWTV ADTVKVDAPG LALLALHWHW VLKHLVHQIP
QLLMNYEDKY YKEVQTVSEH IQNCLGSQTG GFAGVKKLQK FLGRPFPFKD KLVVECFSQL
KVLNKVLAIR EQMPALGESG WQEDLNRLQV VASQWTLKKS LLQAWGLILR ANILEDVNLD
ELKNFVHAHC LELKAKGLSL GFLEKKHGEA SSLSHPDLTS VIHLARSVQL WPAMEYLAML
WQYKVTADFM AQTCLRRCSK NQQPQINEEI SHLISFCLYH TPVAPQELRD LWSLLHHQKV
SPEEITSLWS ELFNSMFISF WNSTVTTNPE YWLMWNPLPG MQQREAPKSV LDSTLKGPGN
LNRPIFSKCC FEVLTSSWRA SPWDVSGLPI LSSSHVTLGE WVERTQQLQD ISSMLWTNMA
ISSVAEFRRT DSQLQGQVLF RHLAGLVELL PECRRQEYMQ NCEQLLLGSS QAFQHVGQTL
GDMAGQEALP KELICQLLTS LHHLFGEGES KGSLPEAAQR GSLWVSLGLL QIQTWLPQAR
FDPAVKREYK LNYAKEELHQ LQCEWKTRNL LSQLQTGRDL EDEVVVSYSH PHVRLLRQRM
DRLDNLTCRL LKKQAFRPQL PAYESLVQEI HHYVTSVAKA PAVQDLLTRL LQALHMDGPR
SAQVAHSLLK EEASWQQSHH QFRKRLAEEY TFYPDAVSPL QASILQLQHG MRLVASELHT
SLYSSMVGAD RLGTLATALL AFPSVGPTFP TYYAHADTLC SVKSEEVLRG LGKLIINCSG
GKEVEGKGQK ACPTREQLLM NALLYLRSHV LCKGELDQRA LQLFRHVCQE IINEWDEQER
IAQEKAEQES SLYRYRSRNS RTTLSEEEEE EREFRKQFPL HEKDFADILV QPALEENKGT
SDGQEEEAAT NPALLSQNSM QAVMLIHQQL CLNFARSLWY QQTLPPHEAK HYLSLFLSCY
QTGASLVTHF YPLMGVELND RLLGSQLLAC TLSHNTLFGE APSDLMMKPD GPYDFYQHPN
VPEARQCQPV LQGFSEAVSH LLQDWPEHPA LEQLLVVVHR IRNFPLSSPI SKFLNGLEIL
LAKAQDWEEN ASRTLSLRKH LDLISQMIIR WRKLELNCWS MSLDNTMKRH TEKSTKHWFS
IYQMLEKHMQ EQTEEQEDDK QMTLMLLVST LQAFIEGSSL GEFHVRLQML LVFHCHVLLM
PQVEGKDSLC SVLWNLYHYY KQFFDRVQAK IVELRSPLEK ELKEFVKISR WNDVSFWSIK
QSVEKTHRTL FKFMKKFEAV LSEPCRSSLV ESDKEEQPDF LPRPTDGAAV EPSSIQNLNR
ALRETLLAQP AAGQATIPEC CQGTAPSGFE GELLRRLPKL RKRMRKICLT LMKESPLPRL
VEGLDQFTGE VISSVSELQN LKVEPSAEKE KQRSEAKHIL MQKQRALSDL FKHLAKIGLS
YRKGLAWAHS KNPQEMLHLH PLDLRSALSI VSSTREADSR LLTEISSSWD GCQKYFYRSL
ARHARLNAAL ATPAKEMGMG NVERCRGFSA HLMKMLVQQR RSLTTLSEQW IILRNLLSCV
QEIHSRLTGP LAYPVAFPPQ DGVQQWTERL QHLAMQCQIL LEQLSWLLQC CPSVRPAPGH
GNAQALGQPP APCLEGPELS KGQLCGVVPD LIPSNLSYPS PVPGSQLPSG CRMRKQDQLW
QQSTTRVTEM LKIIKTVKAD VDKIRQQSCE TLFHSWKDFE VCSSALSCLS QVSVHLQGLE
SLFILPGMEV EQRDSQMALV ESLEYVRGEI SKAMADFTTW KTHLLSSGSQ GGNQMLDEGF
VEDFSEKMEI AIRAILCAIQ NLEESKNEKA EENTDQASPQ EEYAGFERLQ SGHLTKLLED
DFWADVSTLH VQKIISAISE LLERLKSYGE DGTAAKHLFF SQSCSLLVRL VPVLSSYSDL
VLFFLTMSLA THRSTAKLLS VLAQVFTELA QKGFCLPKEF MEDSAGEGAT EFHDYEGGGI
GEGEGMKDVS DQIENEEQVE DTFQKGQEKD KEDPDSKSDI KGEDNAIEMS EDFDGKMHDG
ELEEQEEDDE KSDSEGGDLD KQMGDLNGEE ADKLDERLWG DDNEEEDEEE EDNKTEETGP
GMDEEDSELV AKDDNLDSGN SNKDKSQKDK KEEKEEPEAD DGGEGEDKIK EQIDEREYDE
NEVDPYHGNQ EKLPEPEALD LPDDLNLDSE DRNGGEDTDN EEGEEENPLE IKEKPEEADH
EAEERETETD QNESQSPQEP EEGPSEDDKA KGEEEMDTGA DDQDGDAAQH PEEHSEEQQQ
SLEEKDEEKD KDADEEGGEN GPADQGFQPQ QEEEREDSDT EEQVPEVLER KEHASCGQTG
VENMQSTQAM ELAGAAPEKE QGKEEHGSGV ADANQAEGHE SNFIAQLTSQ KHTRKNTQSF
KRKPGQADNE HSMGDHNERV HKRLRTVDTD SHAEQGPAQQ PQAQVEDADA FEHIKQGSDA
YDAQTYDVAS KEQQQSAKDS GRDQEEEEIE DTLMDTEEQE EFKAVDVEQL KPEEIKLSTT
APLGFDEMEV EIQTVKTEED QDRRTDRAHK ETENEKPERS RESTIHTAHQ FLMDTIFQPF
LKDANELRQE LERQLEMWQP RESGNPEEEK VAAEMWQSYL ILTAPLSQRL CEELRLILEP
TQAAKLKGDY RTGKRLNIRK VIPYIASQFR KDKIWLRRTK PSKRQYQICL AIDDSSSMVD
NHTKQLAFES LAVIGNALTL LEVGQIAVCS FGESVKLLHP FHEQFSDYSG SQILRLCKFQ
QKKTKIAQFL ESVASMFAAA QQLSQNISPE IAQLLLVVSD GRGLFLEGKE RVLAAVQAAR
NANIFVIFVV LDNPSSRDSI LDIKVPIFKG PGEMPEIRSY MEEFPFPYYI ILRDVNALPE
TLSDALRQWF ELVTASDHP
//
