ID   A0A2K6NS85_RHIRO        Unreviewed;       744 AA.
AC   A0A2K6NS85;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Hook microtubule tethering protein 2 {ECO:0000313|Ensembl:ENSRROP00000007095.1};
GN   Name=HOOK2 {ECO:0000313|Ensembl:ENSRROP00000007095.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000007095.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000007095.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the hook family.
CC       {ECO:0000256|ARBA:ARBA00006946}.
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DR   AlphaFoldDB; A0A2K6NS85; -.
DR   STRING; 61622.ENSRROP00000007095; -.
DR   Ensembl; ENSRROT00000030167.1; ENSRROP00000007095.1; ENSRROG00000026930.1.
DR   GeneTree; ENSGT00940000160152; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0070695; C:FHF complex; IEA:Ensembl.
DR   GO; GO:0030897; C:HOPS complex; IEA:Ensembl.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR   GO; GO:0045022; P:early endosome to late endosome transport; IEA:Ensembl.
DR   GO; GO:0007032; P:endosome organization; IEA:Ensembl.
DR   GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR   GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR   GO; GO:1905719; P:protein localization to perinuclear region of cytoplasm; IEA:Ensembl.
DR   CDD; cd22227; HkD_Hook2; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR008636; Hook_C.
DR   InterPro; IPR043936; HOOK_N.
DR   PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR   PANTHER; PTHR18947:SF37; PROTEIN HOOK HOMOLOG 2; 1.
DR   Pfam; PF05622; HOOK; 2.
DR   Pfam; PF19047; HOOK_N; 1.
DR   SUPFAM; SSF116907; Hook domain; 1.
DR   PROSITE; PS50021; CH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT   DOMAIN          6..122
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   REGION          723..744
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          180..427
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          475..561
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          604..631
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   744 AA;  85817 MW;  978FCDB39C61AE09 CRC64;
     MSVDKAELCG SLLTWLQTFH VPSSCASPQD LSSGLAIAYV LNQIDPSWFN EAWLQGISED
     PGPNWKMKVS NLKTVLRSLV EYSQDVLAHP VSEEHLPDVS LIGEFSDPAE LGKLLQLVLG
     CAISCEKKQE HIQRIMTLEE SVQHVVMEAI QELMTKDTPD SLSPETYGNF DSQSRRYYFL
     SEEAEEGDEL KQRCLDLERQ LMLLSEEKQS LAQENAALRE RVGRPEGEGT PGLTAKKLLL
     LQSQLEQLQE ENFRLESGRE DERLRCAELE REVAELQHRN QALTSLAQEA QALKDEMDEL
     RQSSERAGQL EATLTSCRRR LGELRELQRQ VQQLEESNAG HAERTRQLED ELRRAGSLRA
     QLEAQRRQVQ ELQGQRQEEA MKAEKWLFEC RNLEEKYESV TKEKERLLAE RDSLREANEE
     LRCAQLQPRG LTQADPSLDP TSPPMDNLAA EILPAELRET LLRLQLENKR LCRQEAADRE
     RQEELQRHLE EANRARHGLE TQHRLNQQQL SELRAQVEDL QKALQEQGGK TEDSVLLKRK
     LEEHLQKLHE ADLELQRKRE YIEELEPPTD SSSKWDLVTR GWGDPRAQQR EADGPPLPPA
     AGRIEELQHN LQKKDADLRA MEERYRRYVD KARMVMQTVE PKQRPAAGAP PELHSLRTQL
     RERDVRIRHL EMDFEKSRSQ REQEEKLLIR AWYNMGMALQ QRAGEERAPA HAQSFLAQQR
     LATNARRGPL GRLASLNLRP TDKH
//