ID A0A2K6NXS7_RHIRO Unreviewed; 1232 AA.
AC A0A2K6NXS7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Euchromatic histone lysine methyltransferase 2 {ECO:0000313|Ensembl:ENSRROP00000009080.1};
GN Name=EHMT2 {ECO:0000313|Ensembl:ENSRROP00000009080.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000009080.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000009080.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6NXS7; -.
DR Ensembl; ENSRROT00000033162.1; ENSRROP00000009080.1; ENSRROG00000028913.1.
DR GeneTree; ENSGT00940000159459; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd20905; EHMT_ZBD; 1.
DR CDD; cd10533; SET_EHMT2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043550; EHMT1/EHMT2.
DR InterPro; IPR047762; EHMT_CRR.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR038034; SET_EHMT2.
DR PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR PANTHER; PTHR46307:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF21533; EHMT1-2_CRR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT REPEAT 706..738
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 739..771
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 772..796
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 806..838
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 872..904
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 994..1057
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 1060..1177
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..387
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1232 AA; 134319 MW; 0A83623A5D15575B CRC64;
MRGLPRGRGL MRARGRGRAA PPGSRGRGRG GAHRGRGRPR SLLSLPRAQA SWTPQLSTGL
TSPPVPCLPS QGEAPAEMGA LLLEKETRGA TERVHGSLGD TPRSEETLPK ATPDSLEPAG
PSSPASVTVT VGDEGADTPV GATPLIGDES ESLEGDGDLH GGRILLGHAT KSFPSSPSKG
GSCPSRAKMS MTGAGKSPPS VQSLAMRLLS MPGAQGAAAA GPEPPPATTS PEGQPKVHRA
RKTMSKPGNG QPPVPEKRPP EVQHFRMSDD VHSLGKVTSD VVKRRKLTSG GGLSEELGSA
RRSEVTLAKG DPGSLEEWET VVGDDFSLYY DSYSVDERVD SDSKVRQSWS ALPASSGSSG
RRKAKKKWRK DSPWVKPSRK RRKREPPRAK EPRGVNGVGS SGPSEYMEVP LGSLELPSEG
TLSPNHAGVS NDTSSLETER GFEELPLCSC RMEAPKIDRI SERAGHKCMA TESVDGELSG
CNAAILKRET MRPSSRVALM VLCETHRARM VKHHCCPGCG YFCTAGTFLE CHPDFRVAHR
FHKACVSQLN GMVFCPHCGE DASEAQEVTI PRGDGVTPPA GAAAPAPPPL SQDAPGRADT
SQPSARMRGH GEPRRPPCDP LADTIDSSGP SLTLPNGGCL SAVGLPLGPG REALEKALVI
QESERRKKLR FHPRQLYLSV KQGELQKVIL MLLDNLDPNF QSDQQSKRTP LHAAAQKGSV
EICHVLLQAG ANINAVDKQQ RTPLMEAVVN NHLEVARYMV QRGGCVYSKE EDGSTCLHHA
AKIGNLEMVS LLLSTGQVDV NAQDSGGWTP IIWAAEHKHI EVIRMLLTRG ADVTLTDNEE
NICLHWASFT GSAAIAEVLL NARCDLHAVN YHGDTPLHIA ARESYHDCVL LFLSRGANPE
LRNKEGDTAW DLTPERSDVW FALQLNRKLR LGVGNRAIRT EKIICRDVAR GYENVPIPCV
NGVDGESCPE DYKYISENCE TSTMNIDRNI THLQHCTCVD DCSSSNCLCG QLSIRCWYDK
DGRLLQEFNK IEPPLIFECN QACSCWRNCK NRVVQSGIKV RLQLYRTAKM GWGVRALQTI
PQGTFICEYV GELISDAEAD VREDDSYLFD LDNKDGEVYC IDARYYGNIS RFINHLCDPN
IIPVRVFMLH QDLRFPRIAF FSSRDIRTGE ELGFDYGDRF WDIKSKYFTC QCGSEKCKHS
AEAIALEQSR LARLDPHPEL LPELGSLPPV NT
//
