ID A0A2K6NY27_RHIRO Unreviewed; 1234 AA.
AC A0A2K6NY27;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=pyruvate carboxylase {ECO:0000256|ARBA:ARBA00013057};
DE EC=6.4.1.1 {ECO:0000256|ARBA:ARBA00013057};
GN Name=PC {ECO:0000313|Ensembl:ENSRROP00000009184.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000009184.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000009184.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000256|ARBA:ARBA00004742}.
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DR AlphaFoldDB; A0A2K6NY27; -.
DR Ensembl; ENSRROT00000033267.1; ENSRROP00000009184.1; ENSRROG00000028920.1.
DR GeneTree; ENSGT00900000141164; -.
DR OrthoDB; 1129179at2759; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004736; F:pyruvate carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR GO; GO:0006090; P:pyruvate metabolic process; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR CDD; cd07937; DRE_TIM_PC_TC_5S; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 3.10.600.10; pyruvate carboxylase f1077a mutant domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR003379; Carboxylase_cons_dom.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR000891; PYR_CT.
DR InterPro; IPR005930; Pyruv_COase.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR NCBIfam; TIGR01235; pyruv_carbox; 1.
DR PANTHER; PTHR43778; PYRUVATE CARBOXYLASE; 1.
DR PANTHER; PTHR43778:SF2; PYRUVATE CARBOXYLASE, MITOCHONDRIAL; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR Pfam; PF02436; PYC_OADA; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF89000; post-HMGL domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Pyruvate {ECO:0000256|ARBA:ARBA00023317};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 92..542
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 212..409
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 619..888
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
FT DOMAIN 1165..1234
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 1234 AA; 136186 MW; FFCB5129CB9C9E66 CRC64;
MEKLTKAPRA RSLRVRTQGC QDREPKLSPS YWMWLSSAGS RGVYCLPSGE LTKHLRMLKF
RTVRGGLRLL GIRRTSTAPA ASPNVRRLEY KPIKKVMVAN RGEIAIRVFR ACTELGIRTV
AIYSEQDTGQ MHRQKADEAY LIGRGLAPVQ AYLHIPDIIK VAKENNVDAV HPGYGFLSER
ADFAQACQDA GVRFIGPSPE VVRKMGDKVE ARAIAIAAGV PVVPGTDAPI TSLHEAHEFS
NTYGFPIIFK AAYGGGGRGM RVVHSYEELE ENYTRAYSEA LAAFGNGALF VEKFIEKPRH
IEVQILGDQY GNILHLYERD CSIQRRHQKV VEIAPAAHLD PQLRTRLTSD SVKLAKQVGY
ENAGTVEFLV DRHGKHYFIE VNSRLQVEHT VTEEITDVDL VHAQIHVAEG RSLPDLGLRQ
ENIRINGCAI QCRVTTEDPA RSFQPDTGRI EVFRSGEGMG IRLDNASAFQ GAIISPHYDS
LLVKVIAHGK DHPTAATKMS RALAEFRVRG VKTNIPFLQN VLNNQQFLAG TVDTQFIDEN
PELFQLRPAQ NRAQKLLHYL GHVMVNGPTT PIPVKASPSP TDPIVPAVPI GPPPAGFRDI
LLREGPEGFA RAVRNHQGLL LMDTTFRDAH QSLLATRVRT HDLKKIAPYV AHNFSKLFSM
ENWGGATFDV AMRFLYECPW RRLQELRELI PNIPFQMLLR GANAVGYTNY PDNVVFKFCE
VAKENGMDVF RVFDSLNYLP NMLLGMEAAG SAGGVVEAAI SYTGDVSDPS RTKYSLQYYM
GLAEELVRAG THILCIKDMA GLLKPTACTM LVSSLRDRFP DLPLHIHTHD TSGAGVAAML
ACAQAGADVV DVAADSMSGM TSQPSMGALV ACTRGTPLDT EVPMERVFDY SEYWEGARGL
YAAFDCTATM KSGNSDVYEN EIPGGQYTNL HFQAHSMGLG SKFKEVKKAY VEANQMLGDL
IKVTPSSKIV GDLAQFMVQN GLSRAEAEAQ AEELSFPRSV VEFLQGYIGV PHGGFPEPFR
SKVLKDLPRV EGRPGASLPP LDLQALEKEL VDRHGEEVTP EDVLSAAMYP DVFAHFKDFT
ATFGPLDSLN TRLFLQGPRI AEEFEVELER GKTLHIKALA VSDLNRAGQR QVFFELNGQL
RSILVKDTQA MKEMHFHPKA LKDVKGQIGA PMPGKVIDIK VAAGAKVTKG QPLCVLSAMK
METVVTSPME GTVRKVHVTK DMTLEGDDLI LEIE
//
