ID A0A2K6NZK3_RHIRO Unreviewed; 1583 AA.
AC A0A2K6NZK3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Latent transforming growth factor beta binding protein 4 {ECO:0000313|Ensembl:ENSRROP00000009719.1};
GN Name=LTBP4 {ECO:0000313|Ensembl:ENSRROP00000009719.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000009719.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000009719.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 61622.ENSRROP00000009719; -.
DR Ensembl; ENSRROT00000033811.1; ENSRROP00000009719.1; ENSRROG00000029262.1.
DR GeneTree; ENSGT00940000158234; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl.
DR GO; GO:0001527; C:microfibril; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
DR GO; GO:0046879; P:hormone secretion; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.10; Laminin; 20.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF07645; EGF_CA; 17.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 3.
DR SMART; SM00181; EGF; 20.
DR SMART; SM00179; EGF_CA; 19.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 13.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 8.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 112..144
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 250..290
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 320..356
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 370..422
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 546..587
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 588..629
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 630..667
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 669..706
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 711..752
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 793..831
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 837..878
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 879..919
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1008..1049
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1140..1194
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1255..1296
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1308..1361
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1533..1577
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 87..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1405..1482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1130
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1405..1420
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 116..126
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 134..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 657..666
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1583 AA; 168910 MW; 77E92EA84085456B CRC64;
MRDFKALLLV AAAQARRLGG AAASKSLAVS EASCRVRNCQ PRKCAGPQQC LNPVPAVPSP
SPSVRKRQVS LNWQPLTLQE ARALLKRRRP RGPGGRGLLR RRPPQRAPAG KAPVLCPLIC
HNGGVCVKPD RCLCPPDFAG KFCQLHSSGA RPPAPAIPGL TRSVYTMPLA NHRDDEHGVA
SMVSVHVEHP QEASVVVHQV ERVSGPWEEA DAEAVARAEA AARAEAAAPY TVLAQSAPRE
DGFSDASGFG YCFRELRGGE CASPLPGLRT QEVCCRGAGL AWGVHDCQLC SERLGNSGRV
GAPDGPCPTG FERVNGSCED VDECATGGRC QHGECANTRG GYTCVCPDGF LLDSSRSSCI
SQHVISEAKG PCFRVLRDGG CSLPILRNIT KQICCCSRVG KAWGRGCQLC PPFGSEGFRE
ICPAGPGYHY SASDLRYNTR PLGQEPPRVS LSQPRTLPAT SRPSAGFLPT HRPEPRPDHR
PGPELPLPSI PAWIGPEIPD SGPSSGMCQR NPQVCGPGRC ISRPSGYTCA CDSGFRLSPQ
GTRCIDVDEC RRVPPPCAPG RCENSPGSFR CVCGPGFRAG PRAAECLDVD ECHRVPPPCD
LGRCENTPGS FLCVCPAGYQ AAPHGASCQD VDECTQSPGL CGRGACENLP GSFRCVCPAG
FRGSACEEDV DECAQEPPPC GPGRCDNTAG SFHCACPAGF RSRGPGAPCQ DVDECARSPP
PCTYGRCENT EGSFQCVCPT GFQPNAAGSE CEDVDECENH LACPGQECMN SPGSFQCRPC
PPGHHLHRGR CTDVDECSSG APPCGPHGHC TNTEGSFRCS CAPGYRAPSG RAGPCADVNE
CLEGDFCFPH GECLNTDGSF ACTCAPGYRP GPRGASCLDV DECSEEDLCQ SGICTNTDGS
FECICPPGHR AGPDLASCLD VDECRERGPA LCGSQRCENS PGSYRCVRDC DPGYHAGPEG
TCDDVDECQE YGPEICGAQR CENTPGSYRC TPACDPGYQP TPGGGCQDVD ECRNRSFCGA
HAVCQNLPGS FQCLCDQGYE GARDGRHCVD VNECETLQGV CGAALCENVE GSFLCVCPNS
PEEFDPMTGR CVSPRTSAGT FPGSQPQAPA SPVLPARPPP PPPPRRPSTP RQGPVGSGRR
ECYFDTAAPD ACDNILARNV TWQECCCTVG EGWGSGCRIQ QCPGTETAEY QSLCPHGRGY
LAPSGDPSLR RDVDECQLFR DQVCKSGVCV NTAPGYSCYC SNGYYYHTQR LECIDNDECA
DEEPACEGGR CVNTVGSYHC TCEPPLVLDG SQRRCVSNES QSLDDNLGVC WQEVGADLVC
SHPRLDRQAT YTECCCLYGE AWGMDCALCP AQDSDDFEAL CNVLRPPAYS PPRPGGFGLP
YEYGPDLGPP YQGLPYGPEL YPPPALPYDP YPPPPGPFAR REAPYGSSRF DMPDFEDDGG
PYGESEAPAP PGPGTRWPYR SRDTRRSFPE PEELPEGGSY AGSLAEPYEE LEAEECGILD
GCTNGRCVRV PEGFTCRCFD GYRLDMTRMA CVDINECDEA EAASPLCVNA RCLNTDGSFR
CICRQGFAPT HQPHHCAPAR PRA
//
