ID A0A2K6P1G9_RHIRO Unreviewed; 1044 AA.
AC A0A2K6P1G9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 {ECO:0000313|Ensembl:ENSRROP00000010367.1};
GN Name=SMARCA5 {ECO:0000313|Ensembl:ENSRROP00000010367.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000010367.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000010367.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC {ECO:0000256|ARBA:ARBA00009687}.
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DR AlphaFoldDB; A0A2K6P1G9; -.
DR STRING; 61622.ENSRROP00000010367; -.
DR Ensembl; ENSRROT00000034464.1; ENSRROP00000010367.1; ENSRROG00000029591.1.
DR GeneTree; ENSGT00940000156733; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0016590; C:ACF complex; IEA:Ensembl.
DR GO; GO:0110016; C:B-WICH complex; IEA:Ensembl.
DR GO; GO:0000793; C:condensed chromosome; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0043596; C:nuclear replication fork; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0016589; C:NURF complex; IEA:Ensembl.
DR GO; GO:0031213; C:RSF complex; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0090535; C:WICH complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0140751; F:histone octamer slider activity; IEA:Ensembl.
DR GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:Ensembl.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:Ensembl.
DR GO; GO:1905213; P:negative regulation of mitotic chromosome condensation; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IEA:Ensembl.
DR GO; GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl.
DR GO; GO:0045945; P:positive regulation of transcription by RNA polymerase III; IEA:Ensembl.
DR CDD; cd18064; DEXHc_SMARCA5; 1.
DR CDD; cd00167; SANT; 2.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR015194; ISWI_HAND-dom.
DR InterPro; IPR036306; ISWI_HAND-dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR015195; SLIDE.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF49; SWI_SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 1; 1.
DR Pfam; PF09110; HAND; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09111; SLIDE; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 193..358
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 488..639
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 841..893
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 810..841
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 121131 MW; 652FFF29680223B0 CRC64;
MSSAAEPPPP PPPESAPSKP AASTASGGSN SSNKGGPEGV AAQAVASAAS AGPAEAEMEQ
EVFDDASPGK QKEIQEPDPT YEEKMQTDRA NRFEYLLKQT ELFAHFIQPA AQKTPTSPLK
MKPGRPRIKK DEKQNLLSVG DYRHRRTEQE EDEELLTESS KATNVCTRFE DSPSYVKWGK
LRDYQVRGLN WLISLYENGI NGILADEMGL GKTLQTISLL GYMKHYRNIP GPHMVLVPKS
TLHNWMSEFK RWVPTLRSVC LIGDKEQRAA FVRDVLLPGE WDVCVTSYEM LIKEKSVFKK
FNWRYLVIDE AHRIKNEKSK LSEIVREFKT TNRLLLTGTP LQNNLHELWS LLNFLLPDVF
NSADDFDSWF DTNNCLGDQK LVERLHMVLR PFLLRRIKAD VEKSLPPKKE VKIYVGLSKM
QREWYTRILM KDIDILNSAG KMDKMRLLNI LMQLRKCCNH PYLFDGAEPG PPYTTDMHLV
TNSGKMVVLD KLLPKLKEQG SRVLIFSQMT RVLDILEDYC MWRNYEYCRL DGQTPHDERQ
DSINAYNEPN STKFVFMLST RAGGLGINLA TADVVILYDS DWNPQVDLQA MDRAHRIGQT
KTVRVFRFIT DNTVEERIVE RAEMKLRLDS IVIQQGRLVD QNLNKIGKDE MLQMIRHGAT
HVFASKESEI TDEDIDGILE RGAKKTAEMN EKLSKMGESS LRNFTMDTES SVYNFEGEDY
REKQKIAFTE WIEPPKRERK ANYAVDAYFR EALRVSEPKA PKAPRPPKQP NVQDFQFFPP
RLFELLEKEI LFYRKTIGYK VPRNPELPNA AQAQKEEQLK IDEAESLNDE ELEEKEKLLT
QGFTNWNKRD FNQFIKANEK WGRDDIENIA REVEGKTPEE VIEYSAVFWE RCNELQDIEK
IMAQIERGEA RIQRRISIKK ALDTKIGRYK APFHQLRISY GTNKGKNYTE EEDRFLICML
HKLGFDKENV YDELRQCIRN SPQFRFDWFL KSRTAMELQR RCNTLITLIE RENMELEEKE
KAEKKKRGPK PSVSIHEYVN MWIM
//