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Database: UniProt
Entry: A0A2K6P1X2_RHIRO
LinkDB: A0A2K6P1X2_RHIRO
Original site: A0A2K6P1X2_RHIRO 
ID   A0A2K6P1X2_RHIRO        Unreviewed;       491 AA.
AC   A0A2K6P1X2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=Myocilin {ECO:0000256|ARBA:ARBA00017216};
DE   AltName: Full=Trabecular meshwork-induced glucocorticoid response protein {ECO:0000256|ARBA:ARBA00033004};
GN   Name=MYOC {ECO:0000313|Ensembl:ENSRROP00000010532.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000010532.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000010532.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000256|ARBA:ARBA00004138}. Cytoplasmic vesicle
CC       {ECO:0000256|ARBA:ARBA00004541}. Endoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}. Mitochondrion intermembrane space
CC       {ECO:0000256|ARBA:ARBA00004569}. Mitochondrion outer membrane
CC       {ECO:0000256|ARBA:ARBA00004294}. Rough endoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004427}. Secreted, extracellular exosome
CC       {ECO:0000256|ARBA:ARBA00004550}. Secreted, extracellular space,
CC       extracellular matrix {ECO:0000256|ARBA:ARBA00004498}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00446}.
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DR   RefSeq; XP_010369596.1; XM_010371294.1.
DR   AlphaFoldDB; A0A2K6P1X2; -.
DR   STRING; 61622.ENSRROP00000010532; -.
DR   Ensembl; ENSRROT00000034631.1; ENSRROP00000010532.1; ENSRROG00000029667.1.
DR   GeneID; 104668543; -.
DR   KEGG; rro:104668543; -.
DR   CTD; 4653; -.
DR   GeneTree; ENSGT00940000158561; -.
DR   OMA; REVSKWN; -.
DR   OrthoDB; 2876896at2759; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR   GO; GO:0033268; C:node of Ranvier; IEA:Ensembl.
DR   GO; GO:0001968; F:fibronectin binding; IEA:Ensembl.
DR   GO; GO:0005109; F:frizzled binding; IEA:Ensembl.
DR   GO; GO:0032027; F:myosin light chain binding; IEA:Ensembl.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR   GO; GO:0060348; P:bone development; IEA:Ensembl.
DR   GO; GO:0045162; P:clustering of voltage-gated sodium channels; IEA:Ensembl.
DR   GO; GO:0038133; P:ERBB2-ERBB3 signaling pathway; IEA:Ensembl.
DR   GO; GO:0022011; P:myelination in peripheral nervous system; IEA:Ensembl.
DR   GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Ensembl.
DR   GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IEA:Ensembl.
DR   GO; GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl.
DR   GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR   GO; GO:0038031; P:non-canonical Wnt signaling pathway via JNK cascade; IEA:Ensembl.
DR   GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0051894; P:positive regulation of focal adhesion assembly; IEA:Ensembl.
DR   GO; GO:0051901; P:positive regulation of mitochondrial depolarization; IEA:Ensembl.
DR   GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR   GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
DR   GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR   GO; GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0014734; P:skeletal muscle hypertrophy; IEA:Ensembl.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   PANTHER; PTHR23192:SF33; MYOCILIN; 1.
DR   PANTHER; PTHR23192; OLFACTOMEDIN-RELATED; 1.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..491
FT                   /note="Myocilin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014424623"
FT   DOMAIN          231..490
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51132"
FT   REGION          153..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   491 AA;  55642 MW;  E1484453CB5E5808 CRC64;
     MPAVQVLLLA CLVWDVGART AQLRKANDRS GRCQYTFIVA SPNESSCPEQ SQAMSVIHNL
     QKDSSTQRLD LEATKARLSS LESLLHHQLT LDRAARPQET QEGLQRELGT LRQERDQLET
     QTRELETAYS NLLQDKSVLE EEKKRLRQEN ENLARRLESS SQEVARLRRG QCPQIRDTAR
     DVPPGSREVS TWNLDTLAFQ ELKSELTEVP ASRILKESPS GHLRSREGDN GCGELVWVGE
     PLTLRTAETI TGKYGVWMRD PKPTYPYTQE TTWRIDTVGT DVRQVFEYDL IIQFMQGYPS
     KVHILPRPLE STGAVVYSGS LYFQGAESRT VIRYELNTET VKAEKEIPGA GYHGQFPYSW
     GGYTDIDLAV DESGLWVIYS TEEAKGAIVL SKLNPENLEL EQTWETNIRK QSVANAFIIC
     GTLYTVSSYS SADATVNFAY DTGTGISKTL TIPFKNRYKY SSMIDYNPLE KKLFAWDNLN
     MVTYDIKLSK M
//
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