ID A0A2K6P4C8_RHIRO Unreviewed; 1495 AA.
AC A0A2K6P4C8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Neurexin-1 {ECO:0000256|ARBA:ARBA00044151};
DE AltName: Full=Neurexin I-alpha {ECO:0000256|ARBA:ARBA00044347};
DE AltName: Full=Neurexin-1-alpha {ECO:0000256|ARBA:ARBA00044281};
GN Name=NRXN1 {ECO:0000313|Ensembl:ENSRROP00000011382.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000011382.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000011382.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Presynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00035005}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00035005}.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSRROT00000035485.1; ENSRROP00000011382.1; ENSRROG00000029999.1.
DR GeneTree; ENSGT00940000154292; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF51; NEUREXIN-1; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heparan sulfate {ECO:0000256|ARBA:ARBA00023207};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1495
FT /note="Neurexin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014442579"
FT TRANSMEM 1421..1441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..217
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 219..256
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 279..461
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 468..660
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 664..701
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 706..879
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 893..1068
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1071..1108
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1114..1312
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 198..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1462..1495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1462..1478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1479..1495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1495 AA; 164267 MW; 0A78CCFBE70B8D89 CRC64;
MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT
RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR
RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF
KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ
AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKEEYIA TFKGSEYFCY DLSQNPIQSS
SDEITLSFKT LQRNGLMLHT GKSADYVNLA LKNGAVSLVI NLGSGAFEAL VEPVNGKFND
NAWHDVKVTR NLRQVTISVD GILTTTGYTQ EDYTMLGSDD FFYVGGSPST ADLPGSPVSN
NFMGCLKEVV YKNNDVRLEL SRLAKQGDPK MKIHGVVAFK CENVATLDPI TFETPESFIS
LPKWNAKKTG SISFDFRTTE PNGLILFSHG KPRHQKDAKH PQMIKVDFFA IEMLDGHLYL
LLDMGSGTIK IKALLKKVND GEWYHVDFQR DGRSGTISVN TLRTPYTAPG ESEILDLDDE
LYLGGLPENK AGLVFPTEVW TALLNYGYVG CIRDLFIDGQ SKDIRQMAEV QSTAGVKPSC
SRETAKPCLS NPCKNNGMCR DGWNRYVCDC SGTGYLGRSC EREATVLSYD GSMFMKIQLP
VVMHTEAEDV SLRFRSQRAY GILMATTSRD SADTLRLELD AGRVKLTVNL DCIRINCNSS
KGPETLFAGY NLNDNEWHTV RVVRRGKSLK LTVDDQQAMT GQMAGDHTRL EFHNIETGII
TERRYLSSVP SNFIGHLQSL TFNGMAYIDL CKNGDIDYCE LNARFGFRNI IADPVTFKTK
SSYVALATLQ AYTSMHLFFQ FKTTSLDGLI LYNSGDGNDF IVVELVKGYL HYVFDLGNGA
NLIKGSSNKP LNDNQWHNVM ISRDTSNLHT VKIDTKITTQ ITAGARNLDL KSDLYIGGVA
KETYKSLPKL VHAKEGFQGC LASVDLNGRL PDLISDALFC NGQIERGCEG PSTTCQEDSC
SNQGVCLQQW DGFSCDCSMT SFSGPLCNDP GTTYIFSKGG GQITYKWPPN DRPSTRADRL
AIGFSTVQKE AVLVRVDSSS GLGDYLELHI HQGKIGVKFN VGTDDIAIEE SNAIINDGKY
HVVRFTRSGG NATLQVDSWP VIERYPAGNN DNERLAIARQ RIPYRLGRVV DEWLLDKGRQ
LTIFNSQATI IIGGKEQGQP FQGQLSGLYY NGLKVLNMAA ENDANIAIVG NVRLVGEVPS
SMTTESTATA MQSEMSTSIM ETTTTLATST ARRGKPPTKE PISQTTDDIL VASAECPSDD
EDIDPCEPSS GGLANPTRAG GREPYPGSAE VIRESSSTTG MVVGIVAAAA LCILILLYAM
YKYRNRDEGS YHVDESRNYI SNSAQSNGAV VKEKQPSSAK SANKNKKNKD KEYYV
//
