ID A0A2K6P7A6_RHIRO Unreviewed; 231 AA.
AC A0A2K6P7A6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=NFKB inhibitor interacting Ras like 2 {ECO:0000313|Ensembl:ENSRROP00000012408.1};
GN Name=NKIRAS2 {ECO:0000313|Ensembl:ENSRROP00000012408.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000012408.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000012408.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC KappaB-Ras subfamily. {ECO:0000256|ARBA:ARBA00008094}.
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DR AlphaFoldDB; A0A2K6P7A6; -.
DR STRING; 61622.ENSRROP00000012408; -.
DR Ensembl; ENSRROT00000036526.1; ENSRROP00000012408.1; ENSRROG00000030515.1.
DR GeneTree; ENSGT00940000157943; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0032794; F:GTPase activating protein binding; IEA:Ensembl.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR GO; GO:0032484; P:Ral protein signal transduction; IEA:Ensembl.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0043129; P:surfactant homeostasis; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR042227; KBRS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR46152; NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN; 1.
DR PANTHER; PTHR46152:SF2; NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN 2; 1.
DR Pfam; PF00071; Ras; 2.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT REGION 209..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 231 AA; 25743 MW; 82FCEE26283B137B CRC64;
MGKSCKVVVC GQASVGKTSI LEQLLYGNHV VGSEMIETQE DIYVGSIETD RGVREQVRFY
DTRGLRDGAE LPRHCFSCTD GYVLVYSTDS RESFQRVELL KKEIDKSKDK KEGLTLPPRL
ECSGMITAHC SLNLPRLGWS SCLSLCSVPL PQVTIVVLGN KCDLQEQRRV DPDVAQHWAK
SEKVKLWEVS VADRRSLLEP FVYLASKMTQ PQSKSAFPLS RKNKGSGSLD G
//
