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Database: UniProt
Entry: A0A2K6P8X5_RHIRO
LinkDB: A0A2K6P8X5_RHIRO
Original site: A0A2K6P8X5_RHIRO 
ID   A0A2K6P8X5_RHIRO        Unreviewed;       464 AA.
AC   A0A2K6P8X5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Urokinase-type plasminogen activator {ECO:0000256|ARBA:ARBA00019414};
DE            EC=3.4.21.73 {ECO:0000256|ARBA:ARBA00013183};
GN   Name=PLAU {ECO:0000313|Ensembl:ENSRROP00000012998.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000012998.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000012998.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Specifically cleaves the zymogen plasminogen to form the
CC       active enzyme plasmin. {ECO:0000256|ARBA:ARBA00004018}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Specific cleavage of Arg-|-Val bond in plasminogen to form
CC         plasmin.; EC=3.4.21.73; Evidence={ECO:0000256|ARBA:ARBA00000942};
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR   AlphaFoldDB; A0A2K6P8X5; -.
DR   Ensembl; ENSRROT00000037121.1; ENSRROP00000012998.1; ENSRROG00000030786.1.
DR   GeneTree; ENSGT01050000244971; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00108; KR; 1.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 3.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000001; Kringle.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR018056; Kringle_CS.
DR   InterPro; IPR038178; Kringle_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24264; TRYPSIN-RELATED; 1.
DR   PANTHER; PTHR24264:SF38; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; 1.
DR   Pfam; PF00051; Kringle; 1.
DR   Pfam; PF00089; Trypsin; 2.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   PRINTS; PR00018; KRINGLE.
DR   SMART; SM00130; KR; 1.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF57440; Kringle-like; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS00021; KRINGLE_1; 1.
DR   PROSITE; PS50070; KRINGLE_2; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW   ProRule:PRU00121}; Protease {ECO:0000256|RuleBase:RU363034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Serine protease {ECO:0000256|RuleBase:RU363034}.
FT   DOMAIN          30..112
FT                   /note="Kringle"
FT                   /evidence="ECO:0000259|PROSITE:PS50070"
FT   DOMAIN          140..457
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   464 AA;  51931 MW;  3595D1C7312A0AC9 CRC64;
     MSNKYFSSIH WCNCPKKFGG QHCEIDKSKT CYEGNGHFYR GKASTDTMGR SCLAWNSATV
     LQQIYHAHRS DALQLGLGKH NYCRNPDNRR QPWCYVQVGL KQLVQECMVH NCADGKKPSS
     PPEELQFQCG QKTLKPRFKI IGGEFTTIEN QPWFAAIYRR HRGGSVTYVC GGSLISPCWV
     VSATHCFMYG PGFLLFGSSA PPQTHPFLLP SKGFCLISPS SAPLLAAHGL GDKSCFEASR
     EGRGSGRISW DCLMDFFSHS NYPKKEDYIV YLGRSRLNSN TQGEMKFEVE NLILHEDYSA
     DTLAHHNDIA LLKIRSKEGR CAQPSRTIQT ICLPSMYNDP PFGTSCEITG FGKENSTDYL
     YPEQLKMTVV KLISHQKCQQ PHYYGSEVTT KMLCAADPQW ETDSCQGDSG GPLVCSIQGH
     MTLTGIVSWG RGCALKDKPG VYTRVSRFLP WIHSHTREEN GLAL
//
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