ID A0A2K6P9L9_RHIRO Unreviewed; 225 AA.
AC A0A2K6P9L9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Chymotrypsin-like elastase family member 1 {ECO:0000256|ARBA:ARBA00041157};
DE EC=3.4.21.36 {ECO:0000256|ARBA:ARBA00039015};
DE AltName: Full=Elastase-1 {ECO:0000256|ARBA:ARBA00042355};
GN Name=CELA1 {ECO:0000313|Ensembl:ENSRROP00000013233.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000013233.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000013233.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Serine proteases that hydrolyze many proteins in addition to
CC elastin. {ECO:0000256|ARBA:ARBA00037778}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins, including elastin. Preferential
CC cleavage: Ala-|-Xaa.; EC=3.4.21.36;
CC Evidence={ECO:0000256|ARBA:ARBA00036864};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
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DR AlphaFoldDB; A0A2K6P9L9; -.
DR STRING; 61622.ENSRROP00000013233; -.
DR Ensembl; ENSRROT00000037356.1; ENSRROP00000013233.1; ENSRROG00000030882.1.
DR GeneTree; ENSGT01030000234528; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR PANTHER; PTHR24257; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER; 1.
DR PANTHER; PTHR24257:SF0; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 1; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 19..225
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 225 AA; 24263 MW; 629B80A57DC50BE3 CRC64;
LLPHKGHSTQ DFPETNARVV GGTEAGRNSW PSQISLQYLS GGSWYHTCGG TLIRQNWVMT
AAHCVDSPMT FRVVVGDHNL SQNDGTEQYV SVQKIVVHPS WDSNNVAAGY DIALLRLAQS
VTLNSNVQLG VLPQEGAILA NNSPCYITGW GRTKTNGQLA QTLQQAYLPS VDYAICSSSS
YWGSTVKNTM VCAGGDGVHS GCQVNTCRGS LPPRFTPFSC LSLRK
//
