ID A0A2K6PA34_RHIRO Unreviewed; 800 AA.
AC A0A2K6PA34;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Discs large MAGUK scaffold protein 1 {ECO:0000313|Ensembl:ENSRROP00000013390.1};
GN Name=DLG1 {ECO:0000313|Ensembl:ENSRROP00000013390.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000013390.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000013390.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6PA34; -.
DR Ensembl; ENSRROT00000037514.1; ENSRROP00000013390.1; ENSRROG00000030929.1.
DR GeneTree; ENSGT00940000159409; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12031; SH3_DLG1; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF5; DISKS LARGE HOMOLOG 1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM01277; MAGUK_N_PEST; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 108..195
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 203..290
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 350..431
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 465..535
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 610..785
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 15..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 800 AA; 88485 MW; 2D78C70D41E7DC37 CRC64;
MNYIFGNNTL LYSRGSRGGN TSSSHGSAGP KQKHWAKKGS SDELQAEPEP SRWQQIVAFF
TRRHSFIDCI SVATSSTQAN PPPVLVNTES LETPTYVNGT DADYEYEEIT LERGNSGLGF
SIAGGTDNPH IGDDSSIFIT KIITGGAAAQ DGRLRVNDCI LRVNEVDVRD VTHSKAVEAL
KEAGSIVRLY VKRRKPVSEK IMEIKLIKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIEG
GAAHKDGKLQ IGDKLLAVNN VCLEEVTHEE AVTALKNTSD FVYLKVAKPT SMYMNDGYAP
PDITNSSSQP VDNHVSPSSF LGQTPASPAR YSPVSKAVLG DDEITREPRK VVLHRGSTGL
GFNIVGGEDG EGIFISFILA GGPADLSGEL RKGDRIISVN SVDLRAASHE QAAAALKNAG
QAVTIVAQYR PEEYSRFEAK IHDLREQMMN SSISSGSGSL RTSQKRSLYV RALFDYDKTK
DSGLPSQGLN FKFGDILHVI NASDDEWWQA RQVTPDGESD EVGVIPSKRR VEKKERARLK
TVKFNSKTRD KGEIPDDMGS KGLKHVTSNA SDSESSYLIL ITDEYGCSKG GQEEYVLSYE
PVNQQEVNYT RPVIILGPMK DRINDDLISE FPDKFGSCVP HTTRPKRDYE VDGRDYHFVT
SREQMEKDIQ EHKFIEAGQY NNHLYGTSVQ SVREVAEKGK HCILDVSGNA IKRLQIAQLY
PVSIFIKPKS MENIMEMNKR LTEEQARKTF ERAMKLEQEF TEHFTAIVQG DTLEDIYNQV
KQIIEEQSGS YIWVPAKEKL
//
