ID A0A2K6PCA4_RHIRO Unreviewed; 1014 AA.
AC A0A2K6PCA4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Pleckstrin and Sec7 domain containing 4 {ECO:0000313|Ensembl:ENSRROP00000014158.1};
GN Name=PSD4 {ECO:0000313|Ensembl:ENSRROP00000014158.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000014158.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000014158.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
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DR AlphaFoldDB; A0A2K6PCA4; -.
DR STRING; 61622.ENSRROP00000014158; -.
DR Ensembl; ENSRROT00000038286.1; ENSRROP00000014158.1; ENSRROG00000031288.1.
DR GeneTree; ENSGT00940000161976; -.
DR OMA; AKEMTSW; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF338; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 522..694
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 734..850
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1003
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1014 AA; 111451 MW; F6D98CB340B04E73 CRC64;
MMGDHRLSGQ PQPMEILNPY LGDSLEPHPG ECPRETCNHE DLPEPCEEQT WATDPPESTR
QDAPPWGSGV ELTHLGSCSA QGEHRQSTAS PGSPANSHLL GSPQQNRSTS TQVVFWAGIL
QAQMCVLDLE EELEKTEGLK AGLKCCLPTP PVDLPGVTGL HSSPPEDEDS GEDSSEPEGE
GQACLREGTP DSSPQWVAEE DSMFFSNPLF LGSPFSENSA SGERFSWGAS DSHASVRTGS
ESPATLETHL PEGTVLWELE SEPDLGDSAA TSGHRTPPFP VPVYKPHSIC WASVAATDGV
PAAPPGQGES EGDRLGLAPS AAPCVDEAFN WESGCIGSDL GPAAHPVQSW ASPSPEGWQG
GGPFWPQVTL NSQDRGETEA GHLQESGPTL APSPWRSPAS SPEPSSPESE SRGPGPRPSP
ASSQEGSPQL QHHSSGILPK WTLDTSHSSL LEMDGEEPRS LKKEEAGEAP NPGEDVKSEG
IARPAETGDI QPDIHLTSAE HENLRTPMNS SRLPGSPMPQ ARSPEEGQRP PAGDKLANGI
RNNKVAWNLA SRLYRLEGFR KSEVAAYLQK NNDFSRAVAE EYLSFFQFGG QSLDRALRSF
LQALVLSGET QERERILYQF SRRFHHCNLG VFPSVDSVHT LTCAIMLLNT DLHGQNIGKS
MSCQEFITNL NGLRDGGNFP KELLKALYWS IRSEKLEWAV DEEDAAKPEK ARPSLPAGKM
SNPLLQLAQD PTVPTYKQGI LARKMHQDAD GKKTPWGKRG WKMFHTLLRG MVLYFLKQGE
DHCLEGESLV GQMMDEPVGV HHSLATPATH YTKKPHVFQL RTADWRLYLF QAPTAKEMSS
WIARINLAAA THSAPPFPAA VGSQRRFVRP ILPVGPAQSS LEEQHRSHEN CLDAASDDLL
DLQRNLPERR GRSRELEEYR LRKEYLEYEK TRYETYVQLL VARLRCPSNA LDLWEEQLAR
EAGGTQEPKL SLKKSHSSPS LHQDEAPTTA KVKRNISERR TYRKIIPKRN RNQL
//
