ID A0A2K6PCR8_RHIRO Unreviewed; 1418 AA.
AC A0A2K6PCR8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=peptidylprolyl isomerase {ECO:0000256|ARBA:ARBA00013194};
DE EC=5.2.1.8 {ECO:0000256|ARBA:ARBA00013194};
GN Name=NKTR {ECO:0000313|Ensembl:ENSRROP00000014352.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000014352.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000014352.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00000971};
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DR Ensembl; ENSRROT00000038480.1; ENSRROP00000014352.1; ENSRROG00000031389.1.
DR GeneTree; ENSGT00940000158548; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0016018; F:cyclosporin A binding; IEA:UniProt.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR PANTHER; PTHR11071; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE; 1.
DR PANTHER; PTHR11071:SF561; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE H; 1.
DR Pfam; PF00160; Pro_isomerase; 1.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SUPFAM; SSF50891; Cyclophilin-like; 1.
DR PROSITE; PS00170; CSA_PPIASE_1; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Rotamase {ECO:0000256|ARBA:ARBA00023110}.
FT DOMAIN 10..175
FT /note="PPIase cyclophilin-type"
FT /evidence="ECO:0000259|PROSITE:PS50072"
FT REGION 185..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..238
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..458
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..568
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..798
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..914
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..1013
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1061
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1296..1310
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1368..1384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1393..1418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1418 AA; 160823 MW; 1274CDA63B176517 CRC64;
MGAQDRPQCH FDIEINREPV GRIMFQLFSD ICPKTCKNFL CLCSGEKGLG KTTGKKLCYK
GSTFHRVVKN FMIQGGDFSE GNGKGGESIY GGYFKDENFI LKHDRAFLLS MANRGKHTNG
SQFFITTKPA PHLDGVHVVF GLVISGFEVI EQIENLKTDA ASRPYADVRV IDCGVLATKS
VKDVFEKKRK KPTHSEDSDS SSNSSSSSES SSESEIEHER SRRRKHKRRP KVKRSKKRRK
EASSSEEPRN KHVMNPKGHS ERSDTNEKRS VDSSAKREKP VVRPEEIPPV PENRFLLRRD
MPVVTAEPEP KIPDVTPIVS DQKPSVSKSG RKIKGRGTIR YHTPPRSRSC SESDDDDSSE
TPPHWKEEMQ RLRAYRPPSG EKWSKGDKLS DPCSSRWDER SLSQRSRSWS YNGYYSDLST
TRHSDGHHKK RRKEKKVKHK KKGKKQKHCR RHKQTKKRRI LIPSDIESSK SSTRRMKSSC
DRERSSRSSS LSSHHSSKRD WSKSDKDVQS SLTHSSRDSY RSKSHSRSYS RGSSRSRTAS
KSSSQSRSRS KSRSSSKSGH RKRTSKSPRK PASQLSENKP VKTEPLRATM AQNENVVVQP
VVAENIPVIP LSDSPPPSRW KPGQKPWKPS YERIQEMKAK TTHLLPIQST YSLANIKETG
SSSSYHKREK NSESDQSTYS KYSDRSSESS PRSRSRSSRS RSYSRSYTRS RSLASSHSRS
RSPSSRSHSR NKYSDHSQCS RSSSYSSVSS DDGRRGKRRL RSSGKKNSVS HKKHSSSSEK
TLHSKYVKGR DRSSCLRKYS ESRSSLDYSS DSEQSSVQAT QSTQEKEKQG QMERTHNKQE
KNRGEEKSKP ERECPHSKKR TLKENLSDHL RNGSKPKRKN YAGSKWDSES NSERDVTKNS
KNDSRPSSDK EEGEATSDSE SEVSEIHIKV KPTTKSSANT SLPDDNGAWK SSKQRTSTSE
SEGSCSNSEN NRGKPQKHKH GSKENLKREH TKKVKEKLKG KKDKKHKAPK RKQAFHWQPP
LEFGEEEEEE IDDKQVTQES KEKKVSENSE TIKDNIPKPE KSCEEGSLSA LNTEENVTCS
QNIQHVEESV TNGVEDVLQT DDNMEICTPD RSSPAKVEEA SPLGNARLDA PDINIVLKQD
MATEHPEAEV VKQESSMSES KVLSEVGKQD SSSASLASAG ESTGKKDVAE KSQINLIDKK
WKPLQGVGNL AAPTAATSSA VEVKALTTVP EMKPQGLRIE IKSKNKVRPG SLFDEVRKTA
RLNRRPRNQE SSSDEQTPSR DDDSQSRSPS RSRSKSETKS RHRTRSVSYS HSRSRSRSST
SSYRSRSYSR SRSRGWYSRG RTRSRSSSYR SYKSHRSYTY DSYYSRSRSR SRSQRSDSYH
RGRSYNRRSR SCRSYGSDSE SDRSYSHHRS PSESSRYS
//
