ID A0A2K6PCZ3_RHIRO Unreviewed; 998 AA.
AC A0A2K6PCZ3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Protein tyrosine phosphatase receptor type N2 {ECO:0000313|Ensembl:ENSRROP00000014416.1};
GN Name=PTPRN2 {ECO:0000313|Ensembl:ENSRROP00000014416.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000014416.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000014416.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR Ensembl; ENSRROT00000038545.1; ENSRROP00000014416.1; ENSRROG00000031400.1.
DR GeneTree; ENSGT00940000154095; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14610; R-PTP-N2; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF5; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM01305; RESP18; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 728..988
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 907..979
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 98..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..279
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 998 AA; 109838 MW; BA3225B6A88B023B CRC64;
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXGV FGRCQKVPAM DLYRYEVSPV
ALQRLRVALQ KLSGTGFTWQ DDYTQSVMDQ ELADLPKTYL RRPEASGPAR PSKHSIGSER
RYSREGGAAL AKAFRRHLPF LEALSQAPAS DVLARTQTAQ DRPRAEGDDR FSKSILTYVA
HTSALTYPPG PQAQLPEDLL PRTLSQLQPD ELSPKVDSSV ERHHLMAALG AYAAQRPAAP
PGKGSLEPQY LLRAPSRMPR PLLSPAIPQK WPSPLGDPED PPSTGEGAWI HTLLKDLQRQ
PAEARGLSDL ELDGMAELMA GLMQGMDHRG ALGGPGKATL GESGEQADGP KAVLHGESFP
DDGVQDDDDR LYQEVHRLSA TLGGLLQDHG SRLSPGALSF AKPLKMERKK SERPEASLSS
EEETAGVENV KSQTYSKDPL GQQPHSEPGA GAFGELQNQK PGPSEEEQSL PAGAQEALGD
GLQLEVKPSE EEARGYIVTD RDPLRPEEGR QLVEDVAHLL QMPSSVFADV EVLGPAVTFK
VSANVQNVTT ADVEKATVDN KDKLEETSGL KILQTGVGSK SKLKFLPPQV EQEDSTKFIA
LTLVSLACIL GVLLASGLVY CLRHSSQHRL KEKLSGLGRD PGADATAAYQ ELCRQRMATR
PPDRPEGPHT SRISSVSSQF SDGPMPSPSA RSSASSWSEE PVQSNMDIST GHMILSYMED
HLKNKNRLEK EWEALCAYQA EPNSSLVAQK EENVPKNRSL AVLTYDHSRV LLKVENSHSH
SDYINASPIM DHDPRNPAYI ATQGPLPATV ADFWQMVWES GCVVIVMLTP LTENGVRQCY
HYWPDEGSNL YHIYEVNLVS EHIWCEDFLV RSFYLKNLQT NETRTVTQFH FLSWYDRGVP
SSSRSLLDFR RKVNKCYRGR SCPIIVHCSD GAGRSGTYVL IDMVLNKMAK GAKEIDIAAT
LEHLRDQRPG MVQTKEQFEF ALTAVAEEVN AILKALPQ
//
