ID A0A2K6PDE3_RHIRO Unreviewed; 1635 AA.
AC A0A2K6PDE3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Protocadherin related 15 {ECO:0000313|Ensembl:ENSRROP00000014545.1};
GN Name=PCDH15 {ECO:0000313|Ensembl:ENSRROP00000014545.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000014545.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000014545.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSRROT00000038674.1; ENSRROP00000014545.1; ENSRROG00000031150.1.
DR GeneTree; ENSGT00940000156675; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 9.
DR Gene3D; 2.60.40.3430; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 10.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR041149; EC_dom.
DR InterPro; IPR030718; EC_dom_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF431; CADHERIN-RELATED FAMILY MEMBER 5-LIKE ISOFORM X1; 1.
DR Pfam; PF00028; Cadherin; 8.
DR Pfam; PF18432; ECD; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 11.
DR SUPFAM; SSF49313; Cadherin-like; 10.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 10.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1635
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014455284"
FT TRANSMEM 1337..1360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 109..226
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 239..356
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 357..470
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 471..577
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 578..678
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 680..780
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 781..887
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 888..996
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 998..1105
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1106..1220
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 1378..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1382..1406
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1635 AA; 181743 MW; C69F4717B9899ECA CRC64;
MSRMFSNNFL WFAGTILVDN MLIKGTAGGP DPTIELSLKD NVDYWVLMDP VKQMLFLNST
GRVLDRDPPM NIHSIVVQVQ CINKKVGTII YHEVRIVVRD RNDNSPTFKH ESYYATVNEL
TPVGTTIFTG FSGDNGATDI DDGPNGQIEY VIQYNPDDPT SNDTFEIPLM LTGNVVLRKR
LNYEDKTRYF VIIQANDRAQ NLNERRTTTT TLTVDVLDGD DLGPMFLPCV LVPNTRDCRP
LTYQAAIPEL RTPEELNPIV VTPPIQAVDQ DRNIQPPSDR PGILYSILVG TPEDYPRFFH
MHPRTAELSL LEPVNRDFHQ KFDLVIKAEQ DNGHPLPAFA SLHIEILDEN NQSPYFTMPS
YQGYILESAP VGATISDSLN LTSPLRIVAL DKDIEDTKDP ELHLFLNDYT SVFTVTQTGI
TRYLTLLQPV DREEQQTYTF SITAFDGVQE SEPVIINIKV MDANDNTPTF PEISYDVYVY
TDMRPGDSVI QLTAVDADEG SNGEITYEIL VGAQGDFIIN KTTGLITIAP GVEMIVGRTY
ALTVQAADNA PPAERRHSIC TVYIEVLPPN NQSPPRFPQL MYSLEISEAM RVGAVLLNLQ
ATDREGDPIT YAIENGDPQR VFNLSETTGI LTLGKALDRE STDRYILIIT ASDSRPDGTS
TATVNVVVTD VNDNAPVFDP YLPRNLSVVE EEANAFVGQV KATDPDAGIN GQVHYSLGNF
NNLFRITSNG SIYTAVKLNR EVRDYYELVV VATDGAVHPR HSTLTLAIKV LDIDDNSPVF
TNSMYTVLVE ENLPAGTTIL QIEAKDVDLG ANVSYRIRSP EVKHFFALHP FTGELSLLRS
LDYEAFPDQE ASITFLVEAF DIYGTMPPGI ATVTVIVKDM NDYPPVFSKR IYKGMVAPDA
VKGTPITTVY AEDADPPGLP ASRVRYRVDD VQFPYPASIF DVEEDSGRVI TRVNLNEEPT
TIFKLVVVAF DDGEPVMSSS ATVKILVLHP GEIPRFTQEE YRPPPVSELA TKGTMVGVIS
AAAINQSIVY SIVSGNEEDT FGINNITGVI YVNGPLDYEI RTSYVLRVQA DSLEVVLANL
RVPSKSNTAK VYIEIQDENN HPPVFQKKFY IGGVSEDARM FTSVLKVKAT DKDTGNYSVM
AYRLIIPPIK EGKEGFVVET YTGLIKTAML FHNMRRSYFK FQVIATDDYG KGLSGKADIL
VSVVNQLDMQ VIVSNVPPTL VEKKIEDLTE ILDRYVQEQI PGAKVVVESI GARRHGDAFS
LEDYTKCDLT VYAIDPQTNR AIDRNELFKF LDGKLLDINK DFQPYYGEGG RILEIRTPEA
VTSIKKRGES LGYTEGALLA LAFIIILCCI PAILVVLVSY RQRQAECTKT ARIQAALPAA
KPATPAPAPV AAPPPPPPPP PPPGAHLYEE LGDSSMYEMP QYGSRRRLLP PAGQEEYGEV
VGEAEEEYEE EEWARKRMIK LVVDREYETS STGEDSAPEC QRNRLHHPSI HSNINGNIYI
AQNGSVVRTR RACLTDNLKV ASPVRLGRHF KKLDKLAVTH EENVPLNTLS KGPFSTEKMN
ARPTLVTFAP CPVGTDNTAV KPLGNRLKST VEQESMIDSK NIKEALEFHS DHTQSDDEEL
WMGPWNNLHI PMTKL
//
