ID A0A2K6PEE3_RHIRO Unreviewed; 589 AA.
AC A0A2K6PEE3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Zinc finger and BTB domain containing 46 {ECO:0000313|Ensembl:ENSRROP00000014905.1};
GN Name=ZBTB46 {ECO:0000313|Ensembl:ENSRROP00000014905.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000014905.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000014905.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_010363544.1; XM_010365242.1.
DR AlphaFoldDB; A0A2K6PEE3; -.
DR STRING; 61622.ENSRROP00000014905; -.
DR Ensembl; ENSRROT00000039037.1; ENSRROP00000014905.1; ENSRROG00000031639.1.
DR GeneID; 104663859; -.
DR KEGG; rro:104663859; -.
DR CTD; 140685; -.
DR GeneTree; ENSGT00940000158060; -.
DR OMA; FTGDGPY; -.
DR OrthoDB; 5343486at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR GO; GO:0030851; P:granulocyte differentiation; IEA:Ensembl.
DR GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
DR GO; GO:2001199; P:negative regulation of dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:0030853; P:negative regulation of granulocyte differentiation; IEA:Ensembl.
DR GO; GO:0002695; P:negative regulation of leukocyte activation; IEA:Ensembl.
DR GO; GO:0045650; P:negative regulation of macrophage differentiation; IEA:Ensembl.
DR GO; GO:0045656; P:negative regulation of monocyte differentiation; IEA:Ensembl.
DR GO; GO:0002273; P:plasmacytoid dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:2001200; P:positive regulation of dendritic cell differentiation; IEA:Ensembl.
DR CDD; cd18230; BTB_POZ_ZBTB46; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR46105; AGAP004733-PA; 1.
DR PANTHER; PTHR46105:SF20; ZINC FINGER AND BTB DOMAIN CONTAINING 46; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF13465; zf-H2C2_2; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 31..99
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 418..445
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 446..473
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 173..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..565
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 64044 MW; C95333AAB603545B CRC64;
MNNRKEDMEI ASHYRHLLRE LNEQRQHGVL CDVCVVVEGK VFKAHKNVLL GSSRYFKTLY
CQVQKTSEQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR NVIEVMSAAS FLQMTDIVQA
CHDFIKAALD ISIKSDASDE LAEFEIGASS SSSTEALISA VMAGRSISPW LARRTSPANS
SGDSAIASCH DGGSSYGKED QEPKADGPDD VSSQSLWPGD VGYGPLRIKE EQVSPSQYGG
SELPSAKDGA VQNSFSEQSA VDAWQSTGRR KNRKNKQTVR HITQQVEDDS RASSPVPSFL
PTSGWPFSSR DSNADLSVTE ASSSDSRGER AELYAQVEEG LLGGEASYLG PPLTPEKDDA
LHQATAVANL RAALMSKNSL LSLKADVLGD DGSLLFEYLP RGAHSLSLNE FTVIRKKFKC
PYCSFSAMHQ CILKRHMRSH TGERPYPCEI CGKKFTRREH MKRHTLVHSK DKKYVCKVCS
RVFMSAASVG IRHGSRRHGV CADCAGRGMA GPLDHGGGGG EGSPEALFPG DGPYLEDPDD
PRGEAEELGE DDEGLAPEDA LLADDKEEED SPRPRSPPGG PDKDFAWLS
//
