ID A0A2K6PGZ5_RHIRO Unreviewed; 2274 AA.
AC A0A2K6PGZ5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Chondroitin sulfate proteoglycan 4 {ECO:0000313|Ensembl:ENSRROP00000015826.1};
GN Name=CSPG4 {ECO:0000313|Ensembl:ENSRROP00000015826.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000015826.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000015826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR STRING; 61622.ENSRROP00000015826; -.
DR Ensembl; ENSRROT00000039969.1; ENSRROP00000015826.1; ENSRROG00000032078.1.
DR GeneTree; ENSGT00940000154091; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR45739:SF11; C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 11.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS51854; CSPG; 15.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2177..2198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 154..332
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REPEAT 380..475
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 505..597
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 614..716
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 735..830
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 850..941
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 970..1062
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1078..1168
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1190..1289
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1308..1401
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1425..1515
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1533..1631
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1656..1755
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1784..1876
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1893..1981
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1990..2099
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REGION 2135..2156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2274 AA; 245775 MW; F32308FD20E9B34C CRC64;
MLARLVLNSQ PQVIPTTPPL QPRLALCFYE GNDGFKVRLV LGQEELRLQT PAETLLSDSI
PHTTVLTVVE GWATLSVDGL LNASSAVPGA PLEVPYGLFV GGTGSLGLPY LRGTSRPLRG
CLHAATLNGR SLLRPLTPDV HEGCAEEFSA GDDVALGFSG PHSLAAFPAW GTQDEGTLEF
TLTTQSRQAP LAFQAGGRRG DFIYVDIFEG HLRAVVEKGQ GTVLLHNSVP VADGQPHEVS
VHINAHQLEV SVDQYPTRTS NRGVLSYLEP RGSLLLGGLD AEASRHLQEH RLGLTPEATN
ASLLGCMEDL SVNGQRRGLR EALLTRNMVA GCRLEEEEYE DDAYGHYEAF STLAPEAWPA
MELPEPCVPE PGLPPVFTNF TQLLTISPLV VAEGGTAWLE WRHVQPTLDL MEAELRKSQV
LFSVTQGARH GELELDIPGA QARKMFTLLD VVNRKARFIH DGSEDTSDQL VLEVSVTARV
PMPSCLRRGQ TYLLPIQVNP VNDPPRIIFP HGSLMVILEH TQKPLGPEVF QAYDPDSACE
GLTFQFLGAP SGLPVQRRDQ PGEPATEFSC RELEAGSLVY VHRGGPAQDL TFRVSDGLQA
SPPATLKVVA VRPAIQIHRS TGLHLAQGSA MPILPANLSV ETNAVGQDVS VLFRVTGALQ
FGELQKQGAG GVEGAEWWAT QAFHQRDVEQ GRVRYLSTDP QHRTKDTVEN LALEVQVGQE
ILSNLSFPVT IQRATVWMLR LEPLHTQNTQ QETLTTAHLE ATLEEAGPSP PTFHYEVVQA
PRKGNLQLQG TRLSDGQGFT QDDIQAGRVT YGATARASEA VEDTFRFRVT APPYFSPLYT
FPIHIGGDPD APVLTNVLLV VPEGGEGVLS ADHLFVKSLN SASYLYEVME RPRHGRLAWR
GTQDKTTMVT SFTNEDLLHG RLVYQHDDSE TTEDDIPFVA TRQGESSGDM AWEEVRGVFQ
VAIQPVNDHA PVQTISRVFH VARGGRRLLT TDDVAFSDAD SGFADAQLVL TRKDLLFGSI
VAVDEPTRPI YRFTQEDLRK RRVLFVHSGA DRGWIQLQVS DGQHQATALL EVQASEPYLR
VANGSRLVVP QGGQGTIDTA VFHLDTNLDI RSGDEVHYHI TAGPRWGQVL RAGQPATAFS
QQDLLDGAVL YSHNGSLSPR DTLAFSVEAG PVHTDATLQV TVALEGPLAP LKLVRHKKIY
VFQGEAAEIR RDQLEASQEA VPPADIVFSV KKPPSAGYLV MVSRGVLADE PPSLDPVQSF
SQEAVDAGRV LYLHSRPEAW SDAFSLDVAS GLGAPIEGVR VDLEVLPAAI PLEAQNFSVP
EGGSLTLAPP LLRVAGPYFP TLPGLGLQVL EPPRHGALQK EDGPQARTLS AFSWREVEKQ
LIRYVHDGSE TLTDSFVLMA NASEMDRQSH PVAFTVTVLP VNDQPPVLTT NTGLQMWEGA
TVPIPAEVLR STDGDSGSKD LVYTIEQPSN GRVVLRAAPG TEVRSFTQAQ LDGGLVLFSH
RGTLDGGFRF GLSDGEHTSS GHFFRVTAQK RVLLSLEGSR TLTVCPGSVQ PLSSQTLRAS
SSAGTDPQLL LYHVVRGPQL GRLFHAQQDS TGEALVNFTQ AEVYAGNILY EHEMPTEPFW
EAHDTLELQL SSPSAQDVAA TLAVAVSFEA ACPQRPSHLW KNKGLWVPEG QRAKITMAAL
DASNLLASVP SPQRLEHDVL FQVTQFPNRG QLLVSEEPLH AGQPHFLQSQ LATGQLVYAH
GGGGTQQDGF RFRVHLQGPA GATVAGPQTS EAFAITVRDV NERPPQPQAS VPLRLTRGSR
APISRAQLSV VDPDSAPGEI EYEVQRAPHN GFLSLVGGGP GPVTRFTQAD VDSGRLAFVA
NGSSVAGIFQ LSMSDGASPP LPMSLAVDIL PSAIEVQLRA PLEVPQALGR SSLSQQQLRV
VSDREEPEAA YRLIQGPKYG HLLVGGQPAS AFSQLQIDQG EVVFAFTNFS SSHDHFRVLA
LARGVNASAV VNVTVRALLH VWAGGPWPQG ATLRLDPTIL DAGELANRTG SVPHFRLLEG
PRHGRVVRVP RARTEPGGSQ LVEQFTQQDL EDGRLGLEVG RPEGRAPSPT GDSLTLELWA
QGVPPAVASL DFATEPYNAA RPYSVALLSV PEATRMEAGK PESSTPTGKP GPMASSPVPA
VAKGGFLGFL EANMFSVIIP VCLVLLLLAL ILPLLFYLRK RNKTGKHDVQ VLTAKPRNGL
AGDTETFRKV EPGQAIPLTA VPGQGPPPGG QPDPELLQFC RTPNPALKNG QYWV
//
