ID   A0A2K6PH44_RHIRO        Unreviewed;       120 AA.
AC   A0A2K6PH44;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Hedgehog N-terminal signalling domain-containing protein {ECO:0000259|Pfam:PF01085};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000015876.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000015876.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the hedgehog family.
CC       {ECO:0000256|ARBA:ARBA00010649}.
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DR   AlphaFoldDB; A0A2K6PH44; -.
DR   Ensembl; ENSRROT00000040019.1; ENSRROP00000015876.1; ENSRROG00000032102.1.
DR   GeneTree; ENSGT00940000159119; -.
DR   OMA; FRISARP; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0045165; P:cell fate commitment; IEA:UniProt.
DR   GO; GO:0007267; P:cell-cell signaling; IEA:InterPro.
DR   GO; GO:0007417; P:central nervous system development; IEA:UniProt.
DR   GO; GO:0009790; P:embryo development; IEA:UniProt.
DR   GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0009888; P:tissue development; IEA:UniProt.
DR   Gene3D; 3.30.1380.10; -; 1.
DR   InterPro; IPR001657; Hedgehog.
DR   InterPro; IPR009045; Hedgehog_sig/DD-Pept_Zn-bd_sf.
DR   InterPro; IPR000320; Hedgehog_signalling_dom.
DR   PANTHER; PTHR11889; HEDGEHOG; 1.
DR   PANTHER; PTHR11889:SF36; SONIC HEDGEHOG PROTEIN; 1.
DR   Pfam; PF01085; HH_signal; 1.
DR   PRINTS; PR00632; SONICHHOG.
DR   SUPFAM; SSF55166; Hedgehog/DD-peptidase; 1.
PE   3: Inferred from homology;
KW   Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          11..97
FT                   /note="Hedgehog N-terminal signalling"
FT                   /evidence="ECO:0000259|Pfam:PF01085"
SQ   SEQUENCE   120 AA;  13205 MW;  64899F7AEB574699 CRC64;
     MLPLFPSPGL SSSRCKDKLN ALAISVMNQW PGVKLRVTEG WDEDGHHSEE SLHYEGRAVD
     ITTSDRDRSK YGMLARLAVE AGFDWVYYES KAHIHCSVKA GKLALNPGSC DGFCSFGSLV
//