ID   A0A2K6PK51_RHIRO        Unreviewed;      1316 AA.
AC   A0A2K6PK51;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Tetratricopeptide repeat domain 21B {ECO:0000313|Ensembl:ENSRROP00000016923.1};
GN   Name=TTC21B {ECO:0000313|Ensembl:ENSRROP00000016923.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000016923.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000016923.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TTC21 family.
CC       {ECO:0000256|ARBA:ARBA00010935}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_010363603.1; XM_010365301.1.
DR   STRING; 61622.ENSRROP00000016923; -.
DR   Ensembl; ENSRROT00000041074.1; ENSRROP00000016923.1; ENSRROG00000032580.1.
DR   GeneID; 104663912; -.
DR   KEGG; rro:104663912; -.
DR   CTD; 79809; -.
DR   GeneTree; ENSGT00390000005979; -.
DR   OMA; NATCVRA; -.
DR   OrthoDB; 121960at2759; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005929; C:cilium; IEA:GOC.
DR   GO; GO:0030991; C:intraciliary transport particle A; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0060020; P:Bergmann glial cell differentiation; IEA:Ensembl.
DR   GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IEA:Ensembl.
DR   GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IEA:Ensembl.
DR   GO; GO:0035721; P:intraciliary retrograde transport; IEA:Ensembl.
DR   GO; GO:1903999; P:negative regulation of eating behavior; IEA:Ensembl.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0097499; P:protein localization to non-motile cilium; IEA:Ensembl.
DR   GO; GO:1905799; P:regulation of intraciliary retrograde transport; IEA:Ensembl.
DR   GO; GO:0008589; P:regulation of smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040364; TTC21A/TTC21B.
DR   PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR14699:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 21B; 1.
DR   Pfam; PF14559; TPR_19; 1.
DR   Pfam; PF13181; TPR_8; 3.
DR   SMART; SM00028; TPR; 18.
DR   SUPFAM; SSF48452; TPR-like; 5.
DR   PROSITE; PS50005; TPR; 3.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          324..357
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          722..755
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          952..985
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   1316 AA;  150954 MW;  8A80BB2BAE993E6F CRC64;
     MDSQELKTLI NYYCQERYFH HVLLVASEGI KRYGSDPVFR FYHAYGTLME GKTQEALREF
     EAIKNKQDVS LCSLIALIYA HKMSPNPDRE AILESDARVK EQRKGAGEKA LYHAGLFLWH
     IGRHDKAREY IDRMIKTSDG RKQGHVLKAW LDITRGKDPY TKKALKYFEE GLQDGNDTFA
     LLGKAQCLEM RQNYSGALET VNQIIVNFPS FLPAFVKKMK LQLALQDWDQ TVETAQRLLL
     QDSQNVEALR MQALYYVCRE GDIEKASTKL ENLGNALDAM EPQNAQLFYN ITLAFSRTCG
     RSQLILQKIQ MLLERAFSLN PQQSEFAAEL GYQMILQGRI KEALKWYKTA MTLDETSVSA
     LVGFIQCQLI EGQLQDADQQ LEFLNEIQQS IGKSAELIYL HAVLAMKKNK RQEEVINLLN
     DVLDTHFSQI EGLPLGIQYF EKLNPDFLLE IVMEYLSFCP MQPASPGQPL CPLLRRCVSV
     LETVVRTVPG LLQTVFLIAK VKYLSGDIEA AFNNLQHCLE HNPSYADAHL LLAQVYLSQE
     KVKLCSQSLE LCLSYDFKVR EYPLYHLIKA QSQKQMGEIA DAIKTLHMAT SLPGMKRIGA
     STKSKDRKTE VDTSHRLSIF LELIELHRLN GEQHEAAKVL QDAIHEFSGT SEEVRVTIAN
     ADLALAQGDI ERALSILQNV TAEQPYFIEA REKMADIYLK HRKDKMLYIT CFREIAERMA
     NPRSFLLLGD AYMNILEPEE AIVAYEQALN QNPKDGTLAS KMGKALIKTH NYSMAITYYE
     TALKSGQKNY LCYDLAELLL KLKWYDKAEK VLQHALAHEP VNELSALMED GRCQVLLAKV
     YSKMERPGDA ITALQQAREL QARVLKRVQM EQPDAVPAQK HLAAEICAKI AKHSVAQRDY
     EKAIKFYREA LVHCETDNKI MLELARLYLA QDDPDSCLRQ CALLLQSDQD NEAATMMMAD
     LMFRKQDYEQ AVFHLQQLLE RKPDNYMTLS RLIDLLRRCG KLEDVPRFFS MAEKRNSRAK
     LEPGFQYCKG LYLWYTGEPN DALRHFNKAR KDRDWGQNAL YNMIEICLNP DNETIGGEVF
     ENLDGDLGNS TEKQESVQLA VRTAEKLLKE LKPQTVQGHV QLRIMENYCL MATKQKSNVE
     QALNTFTEIA ASEKDHIPAL LGMATAYMIL KQTPRARNQL KRIAKMNWNA IDAEEFEKSW
     LLLADIYIQS AKYDMAEELL KRCLRHNRSC CKAYEYMGYI MEKEQAYTDA ALNYEMAWKY
     SNRTNPAVGY KLAFNYLKAK RYVDSIDICH QVLEAHPTYP KIRKDILDKA HASLRP
//