ID A0A2K6PLN7_RHIRO Unreviewed; 1148 AA.
AC A0A2K6PLN7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Solute carrier family 12 member 2 {ECO:0000313|Ensembl:ENSRROP00000017453.1};
GN Name=SLC12A2 {ECO:0000313|Ensembl:ENSRROP00000017453.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000017453.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000017453.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6PLN7; -.
DR Ensembl; ENSRROT00000041605.1; ENSRROP00000017453.1; ENSRROG00000032761.1.
DR GeneTree; ENSGT00940000155742; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 283..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 734..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 200..251
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 288..790
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 799..1144
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 36..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1148 AA; 124351 MW; BFAFBA5F3BBC8AAF CRC64;
MEPVPTAPSS GAPGLAGVGE TPPAAALAAA RVELPGTAVP SVPEDAAPTS RDGGGVRGEG
AAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAAAA AAAAAASAGA GAKQTPADGE
GSGESGPAKG SEEAKGRFRV NFVDPAASSS AEDSLSDAAG VGGDGPNVSF QNGGDTVLSE
GSSLHSGGGG SGHHQHYYYD THTNTYYLRT FGHNTMDAVP RIDHYRHTAA QLGEKLLRPS
LAELHDELEK EPFEDGFANG EESTPTRDAV VTYTAESKGV VKFGWIKGVL VRCMLNIWGV
MLFIRLSWIV GQAGIGLSVL VIMMATVVTT ITGLSTSAIA TNGFVRGGGA YYLISRSLGP
EFGGAIGLIF AFANAVAVAM YVVGFAETVV ELLKEHSILM IDEINDIRII GAITVVILLG
ISVAGMEWEA KAQIVLLVIL LLAIGDFVIG TFIPLESKKP KGFFGYKSEI FNENFGPDFR
EEETFFSVFA IFFPAATGIL AGANISGDLA DPQSAIPKGT LLAILITTLV YVGIAVSVGS
CVVRDATGNV NDTIVTELTN CTSAACKLNF DFSSCEISPC SYGLMNNFQV MSMVSGFTPL
ISAGIFSATL SSALASLVSA PKIFQALCKD NIYPAFQMFA KGYGKNNEPL RGYILTFLIA
LGFILIAELN VIAPIISNFF LASYALINFS VFHASLAKSP GWRPAFKYYN MWISLLGAIL
CCIVMFVINW WAALLTYVIV LGLYIYVTYK KPDVNWGSST QALTYLNALQ HSIRLTGVED
HVKNFRPQCL VMTGAPNSRP ALLHLVHDFT KNVGLMICGH VHMGPRRQAM KEMSIDQAKY
QRWLIKNKMK AFYAPVHADD LREGAQYLMQ AAGLGRMKPN TLVLGFKKDW LQADMRDVDM
YINLFHDAFD IQYGVVVIRL KEGLDISHLQ GQEELLSSQE KSPVTKDVVV SVEYSKKSDL
DTSKPLSEKP VTHKVEEEDG KTATQPLLKK ESKGPIVPLN VADQKLLEAS TQFQKKQGKN
TIDVWWLFDD GGLTLLIPYL LTTKKKWKDC KIRVFIGGKI NRIDHDRRAM ATLLSKFRID
FSDIMVLGDI NTKPKKENII AFEEMIEPYR LHEDDKEQDI ADKMKEDEPW RITDNELELY
KTKFYEPC
//
