ID   A0A2K6PM93_RHIRO        Unreviewed;      1253 AA.
AC   A0A2K6PM93;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Cytoplasmic FMR1-interacting protein {ECO:0000256|PIRNR:PIRNR008153};
GN   Name=CYFIP1 {ECO:0000313|Ensembl:ENSRROP00000017663.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000017663.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000017663.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Synapse, synaptosome
CC       {ECO:0000256|ARBA:ARBA00034102}.
CC   -!- SIMILARITY: Belongs to the CYFIP family.
CC       {ECO:0000256|ARBA:ARBA00025790, ECO:0000256|PIRNR:PIRNR008153}.
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DR   RefSeq; XP_010360477.1; XM_010362175.1.
DR   RefSeq; XP_010360478.1; XM_010362176.1.
DR   AlphaFoldDB; A0A2K6PM93; -.
DR   STRING; 61622.ENSRROP00000017663; -.
DR   Ensembl; ENSRROT00000041817.1; ENSRROP00000017663.1; ENSRROG00000032912.1.
DR   GeneTree; ENSGT00500000044831; -.
DR   OMA; HKESFFY; -.
DR   OrthoDB; 446059at2759; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR   GO; GO:0005845; C:mRNA cap binding complex; IEA:Ensembl.
DR   GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR   GO; GO:0031209; C:SCAR complex; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR   GO; GO:0050890; P:cognition; IEA:Ensembl.
DR   GO; GO:0097484; P:dendrite extension; IEA:Ensembl.
DR   GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
DR   GO; GO:0099563; P:modification of synaptic structure; IEA:Ensembl.
DR   GO; GO:2000601; P:positive regulation of Arp2/3 complex-mediated actin nucleation; IEA:Ensembl.
DR   GO; GO:0010592; P:positive regulation of lamellipodium assembly; IEA:Ensembl.
DR   GO; GO:0051388; P:positive regulation of neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   GO; GO:1905274; P:regulation of modification of postsynaptic actin cytoskeleton; IEA:Ensembl.
DR   GO; GO:0099578; P:regulation of translation at postsynapse, modulating synaptic transmission; IEA:Ensembl.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   InterPro; IPR008081; Cytoplasmic_FMR1-int.
DR   PANTHER; PTHR12195:SF4; CYTOPLASMIC FMR1-INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR12195; CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED; 1.
DR   Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
DR   Pfam; PF05994; FragX_IP; 1.
DR   PIRSF; PIRSF008153; FMR1_interacting; 1.
DR   PRINTS; PR01698; CYTOFMRPINTP.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR008153};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT   DOMAIN          64..273
FT                   /note="CYRIA/CYRIB Rac1 binding"
FT                   /evidence="ECO:0000259|Pfam:PF07159"
SQ   SEQUENCE   1253 AA;  145092 MW;  AC5F19FF65C25AD5 CRC64;
     MAAQVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSLLYQP NFNTNFEDRN AFVTGIARYI
     EQATVHSSMN EMLEEGQEYA VMLYTWRSCS RAIPQVKCNE QPNRVEIYEK TVEVLEPEVT
     KLMNFMYFQR NAIERFCGEV RRLCHAERRK DFVSEAYLIT LGKFINMFAV LDELKNMKCS
     VKNDHSAYKR AAQFLRKMAD PQSIQESQNL SMFLANHNKI TQSLQQQLEV ISGYEELLAD
     IVNLCVDYYE NRMYLTPSEK HMLLKVMGFG LYLMDGSVSN IYKLDAKKRI NLSKIDKYFK
     QLQVVPLFGD MQIELARYIK TSAHYEENKS RWTCTSSGSS PQYNICEQMI QIREDHMRFI
     SELARYSNSE VVTGSGRQEA QKTDAEYRKL FDLALQGLQL LSQWSAHVME VYSWKLVHPT
     DKYSNKDCPD SAEEYERATR YNYTSEEKFA LVEVIAMIKG LQVLMGRMES VFNHAIRHTV
     YAALQDFSQV TLREPLRQAI KKKKNVIQSV LQAIRKTVCD WETGHEPFND PALRGEKDPK
     SGFDIKVPRR AVGPSSTQLY MVRTMLESLI ADKSGSKKTL RSSLEGPTIL DIEKFHRESF
     FYTHLINFSE TLQQCCDLSQ LWFREFFLEL TMGRRIQFPI EMSMPWILTD HILETKEASM
     MEYVLYSLDL YNDSAHYALT RFNKQFLYDE IEAEVNLCFD QFVYKLADQI FGYYKVMAGS
     LLLDKRLRSE CKNQGATIHL PPSNRYETLL KQRHVQLLGR SIDLNRLITQ RVSAAVCKSL
     ELAIGRFESE DLTSIVELDG LLEINRMTHK LLSRYLTLDS FDAMFREANH NVSAPYGRIT
     LHVFWELNYD FLPNYCYNGS TNRFVRTVLP FSQEFQRDKQ PNAQPQYLHG SKALNLAYSS
     IYGSYRNFVG PPHFQVICRL LGYQGIAVVM EELLKVVKSL LQGTILQYVK TLMEVMPKIC
     RLPRHEYGSP GILEFFHHQL KDIVEYAELK TVCFQNLREV GNAVLFCLLI EQSLSLEEVC
     DLLHAAPFQN ILPRVHVKEG ERLDAKMKRL ESKYAPLHLV PLIERLGTPQ QIAIAREGDL
     LTKERLCCGL SMFEVILTRI RSFLDDPIWR GPLPSNGVMH VDECVEFHRL WSAMQFVYCI
     PVGTHEFTVE QCFGDGLHWA GCMIIVLLGQ QRRFAVLDFC YHLLKVQKHD GKDEIIKNVP
     LKKMVERIRK FQILNDEIIT ILDKYLKSGD GEGTPVEHVR CFQPPIHQSL ASS
//