ID A0A2K6PMG1_RHIRO Unreviewed; 939 AA.
AC A0A2K6PMG1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Ankyrin repeat and LEM domain containing 2 {ECO:0000313|Ensembl:ENSRROP00000017723.1};
GN Name=ANKLE2 {ECO:0000313|Ensembl:ENSRROP00000017723.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000017723.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000017723.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSRROT00000041878.1; ENSRROP00000017723.1; ENSRROG00000032950.1.
DR GeneTree; ENSGT00390000016767; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0051721; F:protein phosphatase 2A binding; IEA:Ensembl.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0007084; P:mitotic nuclear membrane reassembly; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0042326; P:negative regulation of phosphorylation; IEA:Ensembl.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; IEA:Ensembl.
DR CDD; cd12944; LEM_ANKL2; 1.
DR Gene3D; 1.10.720.40; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011015; LEM/LEM-like_dom_sf.
DR InterPro; IPR035006; LEM_ANKL2.
DR InterPro; IPR003887; LEM_dom.
DR InterPro; IPR011320; RNase_H1_N.
DR InterPro; IPR037056; RNase_H1_N_sf.
DR PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR12349:SF4; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01693; Cauli_VI; 1.
DR Pfam; PF03020; LEM; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF63451; LEM domain; 1.
DR PROSITE; PS50954; LEM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 69..113
FT /note="LEM"
FT /evidence="ECO:0000259|PROSITE:PS50954"
FT REGION 745..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 939 AA; 104377 MW; EA4906EB60EB7978 CRC64;
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XEMTMDAVLA RLKLLNPDDL REEIVKAGLK CGPITSTTRF IFEKKLAQAL LEQGGRLPSF
DHHEAGATAL SQDTQRILKS AEGNPIDQAG FSEDRDFGYS VGLNPPEEEA VTSKTCSVPP
SAVDTYRTGV TASKEPPLYY GVCPVYEDVP ARNDRIHVYE NKKEALQAVK MIKGSRFKAF
STREDAEKFA RGICDYFPSP SRTSLPLSPV KTAPLFSNDG LKDGLCLSES ETVNKERANS
YKNPRTQDLT AKLRKAVEKG EEDTFSDLIW SNPRYLIGSG DNPTIVQEGC RYNVMHVAAK
ENQASICQLT LDVLENPDFM RLMYPDDDEA MLQKRIRYVV DLYLNTPDKM GYDTPLHFAC
KFGNADVVNV LSSHHLIVKN PRNKYDKTPE DVICERSKNK SVELKERIRE YLKGHYYVPL
LRAEDTSSPV IGELWSPDQT AEASHVSRYG GSPRDPVLTL RAFTGPLSPA KAEDFRKLWK
TPPREKAGFL HHVKKSDPER GFERVGRELA HELGYPWVEY WEFLGCFVDL SSQEGLQRLE
EYLTQQEIGK KAQQETGERE ASCRDKATMS GSNSISVRAF LDEDDMSLEE IKNRQNVARN
HSPPTAGAFG YARCSIFPLE QEADVIEAAE PGGPHSSSNG LCHPLSHSRT LVGKRPKAPC
GEEAHLPPVS DLTVEFDKLN LQNVGSSVSK TPDENMKTKD KSLTSRIDAV ERDLLEPPSP
ADQLGTGRRR TESEMSARIA KMSFSPSSPG HEGQLEVTRE PARRLFLFGE EPSKLDQDVL
AALECADVNP HQFPAVHRWK TAVLCYSPSD RQSWPSPAVK GKFKSRLPDL SGPHSYSLGR
NSAAGSNPGK PGPGSPGRYS PAHGNQLRRM ARLPELAAL
//
