UniProt: A0A2K6PNF4

Database: UniProt
Entry: A0A2K6PNF4_RHIRO

LinkDB:  A0A2K6PNF4_RHIRO 
Original site:  A0A2K6PNF4_RHIRO

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Ontology (6)   
   GO (6)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (5)   
   InterPro (3)   
   Pfam (2)   
All databases (17)   

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ID   A0A2K6PNF4_RHIRO        Unreviewed;       383 AA.
AC   A0A2K6PNF4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein {ECO:0000256|RuleBase:RU369013};
GN   Name=ERGIC3 {ECO:0000313|Ensembl:ENSRROP00000018071.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000018071.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000018071.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000256|RuleBase:RU369013}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU369013}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457,
CC       ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004457, ECO:0000256|RuleBase:RU369013}. Golgi
CC       apparatus membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane
CC       protein {ECO:0000256|RuleBase:RU369013}. Golgi apparatus, cis-Golgi
CC       network membrane {ECO:0000256|ARBA:ARBA00004257}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004257}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ERGIC family.
CC       {ECO:0000256|ARBA:ARBA00005648, ECO:0000256|RuleBase:RU369013}.
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DR   RefSeq; XP_010384843.1; XM_010386541.1.
DR   AlphaFoldDB; A0A2K6PNF4; -.
DR   SMR; A0A2K6PNF4; -.
DR   Ensembl; ENSRROT00000042228.1; ENSRROP00000018071.1; ENSRROG00000033106.1.
DR   GeneID; 104680535; -.
DR   KEGG; rro:104680535; -.
DR   CTD; 51614; -.
DR   GeneTree; ENSGT00530000063113; -.
DR   OMA; QRHEGCR; -.
DR   OrthoDB; 506854at2759; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:UniProtKB-UniRule.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:UniProtKB-UniRule.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN; 1.
DR   PANTHER; PTHR10984:SF25; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU369013};
KW   ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW   ECO:0000256|RuleBase:RU369013};
KW   Golgi apparatus {ECO:0000256|RuleBase:RU369013};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369013};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU369013};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU369013}; Transport {ECO:0000256|RuleBase:RU369013}.
FT   TRANSMEM        20..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369013"
FT   TRANSMEM        341..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369013"
FT   DOMAIN          7..97
FT                   /note="Endoplasmic reticulum vesicle transporter N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13850"
FT   DOMAIN          145..363
FT                   /note="Endoplasmic reticulum vesicle transporter C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07970"
SQ   SEQUENCE   383 AA;  43222 MW;  8370FB3067AD95CE CRC64;
     MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL TTEVHPELYV
     DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE HNLFKQRLDK DGIPVSSEAE
     RHELGKVEVT VFDPDSLDPD RCESCYGAEA EDIKCCNTCE DVREAYRRRG WAFKNPDTIE
     QCRREGFSQK MQEQKNEGCQ VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI
     NMTHYIQHLS FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF
     SVTRHEKVAN GLLGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA IIGGMFTVAG
     LIDSLIYHSA RAIQKKIDLG KTT
//

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