ID A0A2K6PPB4_RHIRO Unreviewed; 939 AA.
AC A0A2K6PPB4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN Name=TMTC1 {ECO:0000313|Ensembl:ENSRROP00000018344.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000018344.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000018344.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR AlphaFoldDB; A0A2K6PPB4; -.
DR STRING; 61622.ENSRROP00000018344; -.
DR Ensembl; ENSRROT00000042504.1; ENSRROP00000018344.1; ENSRROG00000033217.1.
DR GeneTree; ENSGT00940000158027; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44809; -; 1.
DR PANTHER; PTHR44809:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC1; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13432; TPR_16; 2.
DR Pfam; PF14559; TPR_19; 1.
DR Pfam; PF07719; TPR_2; 1.
DR SMART; SM00386; HAT; 3.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 8.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 108..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 349..421
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 540..573
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 605..638
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 639..672
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 673..706
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 740..773
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 808..841
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 846..879
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 880..913
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 244..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 939 AA; 105759 MW; CCEF92171C5DABE7 CRC64;
VGDWTRARGG WRASHRGCGL APAGAAALLA GASCLCYGRS LQGEFVHDDV WAIVNNPDVR
PGAPLRWSIF TNDFWGKGMA ENTSHKSYRP LCVLTFKLNI FLTGMNPFYF HAVNVILHCL
VTLVLMYTCD KTVFKNRGLA FVTALLFAVH PIHTEAVAGI VGRADVLACL LFLLAFLSYN
RSLDQGCVGE SFPSTVSPFF LLFSLFLGTC AMLVKETGIT VFGVCLVYDL FSLSNKEDKS
NGALCPCSPQ QPGSPQPSSL PGHPHRENGK QQRFPHKGAW GGCHSPLPPE PKSSGFPVSP
QAVWSMMRYL RASSNRNFLL TMRPFLKRAI LVLSYVLVIL YFRLWIMGGS MPLFSEQDNP
ASFSPYILTR FLTYSYLLAF NVWLLLAPVT LCYDWQVGSI PLVETIWDMR NLATILLAVV
MALLSLHCLA AFKRLEHKEV LVGLLFLVFP FIPASNLFFR VGFVVAERVL YMPSMGYCIL
FVHGLSKLCT WLNRCGATTL IVSTVLLLLL FSWKTVKQNE IWLSRESLFR SGVQTLPHNA
KVHYNYANFL KDQGRNKEAI YHYRTALKLY PRHASALNNL GTLTRDTAEA KMYYQRALQL
HPQHNRALFN LGNLLKSQEK KEEAITLLKD SIKYGPEFAD AYSSLASLLA EQERFKEAEE
IYQAGIKNCP DSSDLHNNYG VFLVDTGLPE KAVAHYQQAI KLSPSHHVAM VNLGRLYRSL
GENSMAEEWY KRALQVAHKA EILSPLGALY YNTGRYEEAL QIYQEAAALQ PSQRELRLAL
AQVLAVMGQT KEAEKMTNHI VSEETGCLEC YRLLSAIYSK QENHDKALDV IDKALQLKPK
DPKVISELFF TKGNQLREQN LLDKAFESYR AAVQLNPDQA QAWMNMGGIQ HIKGKYVSAR
AYYERALQLV PDSKLLKENL AKLDRLEKRL QEVREKDQT
//
