ID   A0A2K6PPU0_RHIRO        Unreviewed;       891 AA.
AC   A0A2K6PPU0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE            EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
GN   Name=DPP8 {ECO:0000313|Ensembl:ENSRROP00000018524.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000018524.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000018524.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC         polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC         Pro nor hydroxyproline.; EC=3.4.14.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001257};
CC   -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC       {ECO:0000256|ARBA:ARBA00010036}.
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DR   RefSeq; XP_010353808.1; XM_010355506.1.
DR   AlphaFoldDB; A0A2K6PPU0; -.
DR   STRING; 61622.ENSRROP00000018524; -.
DR   Ensembl; ENSRROT00000042684.1; ENSRROP00000018524.1; ENSRROG00000033287.1.
DR   GeneID; 104655949; -.
DR   KEGG; rro:104655949; -.
DR   CTD; 54878; -.
DR   GeneTree; ENSGT00940000160717; -.
DR   OMA; AMQADKF; -.
DR   OrthoDB; 170111at2759; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:Ensembl.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0043069; P:negative regulation of programmed cell death; IEA:Ensembl.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR045785; Dpp_8/9_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF98; DIPEPTIDYL PEPTIDASE 8; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF19520; Dpp_8_9_N; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT   DOMAIN          2..155
FT                   /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19520"
FT   DOMAIN          168..587
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          680..883
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   891 AA;  102414 MW;  F6C37A24BE1CC7B6 CRC64;
     MKIKSGKCNM AAAMETEQLG VEIFETADCE ENIESQDRPK LEPFYVERYS WSQLKKLLAD
     TRKYHGYMMA KAPHDFMFVK RNDPDGPHSD RIYYLAMSGE NRENTLFYSE IPKTINRAAV
     LMLSWKPLLD LFQATLDYGM YSREEELLRE RKRIGTVGIA SYDYHQESGT FLFQAGSGIY
     HIKDGGPQGF TQQPLRPNLV ETSCPNIRMD PKLCPADPDW IAFIHSNDIW ISNIVTREER
     RLTYVHNELA NMEEDARSAG VATFVLQEEF DRYSGYWWCP KAETTPSGGK ILRILYEEND
     ESEVEIIHVT SPMLETRRAD SFRYPKTGTA NPKVTFKMSE IMIDTEGRIM DVIDKELIQP
     FEILFEGVEY IARAGWTPEG KYAWSILLDR SQTHLQIVLI SPELFIPVED DVMERQRLIE
     SVPDSVTPLI IYEETTDIWI NIHDIFHVFP QSHEEEIEFI FASECKTGFR HLYKITSVLK
     ESKYKRSSGG LPAPSDFKCP IKEEIAITSG EWEVLGRHGS NIQVDEVRSL VYFEGTKDSP
     LEHHLYVVSY VNPGEVTRLT DRGYSHSCCI SQHCDFFISK YSNQKNPHCV SLYKLSSPED
     DPACKTKEFW ATILDSAGPL PDYTPPEIFS FESTTGFTLY GMLYKPHDLQ PGKKYPTVLF
     IYGGPQVQLV NNRFKGVKYF RLNTLASLGY VVVVIDNRGS CHRGLKFEGA FKYKMGQIEI
     DDQVEGLQYL ASRYDFIDLD RVGIHGWSYG GYLSLMALMQ RSDIFRVAIA GAPVTLWIFY
     DTGYTERYMG HPDQNEQGYY LGSVAMQAEK FPSEPNRLLL LHGFLDENVH FAHTSILLSF
     LVRAGKPYDL QIYPQERHSI RVPESGEHYE LHLLHYLQEN LGSRIAALKV I
//