ID   A0A2K6PTM6_RHIRO        Unreviewed;      1258 AA.
AC   A0A2K6PTM6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Signal induced proliferation associated 1 like 1 {ECO:0000313|Ensembl:ENSRROP00000019869.1};
GN   Name=SIPA1L1 {ECO:0000313|Ensembl:ENSRROP00000019869.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000019869.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000019869.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6PTM6; -.
DR   Ensembl; ENSRROT00000044044.1; ENSRROP00000019869.1; ENSRROG00000033872.1.
DR   GeneTree; ENSGT00940000155944; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR021818; SIPA1L_C.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15711:SF10; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 1; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   Pfam; PF11881; SPAR_C; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW   ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT   DOMAIN          75..292
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   DOMAIN          429..493
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          543..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          620..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          723..761
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          782..819
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          835..930
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1195..1243
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        543..569
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        620..642
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        658..687
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        725..754
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        782..804
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        849..895
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        910..930
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1258 AA;  139338 MW;  341DDFC40B64AA40 CRC64;
     GFSLLSPYKA SPQHLSLLQL MTLRGSVLED AIPSTAKHST ARGLPLKEVL EHVVPELNVQ
     CLRLAFNTPK VTEQLMKLDE QGLNYQQKVG IMYCKAGQST EEEMYNNESA GPAFEEFLQL
     LGERVRLKGF EKYRAQLDTK TDSTGTHSLY TTYKDYEIMF HVSTMLPYTP NNKQQLLRKR
     HIGNDIVTIV FQEPGAQPFS PKNIRSHFQH VFVIVRVHNP CSDSVCYSVA VTRSRDVPSF
     GPPIPKGVTF PKSNVFRDFL LAKVINAENA AHKSEKFRAM ATRTRQEYLK DLAEKNVTNT
     PIDPSGKFPF ISLASKKKEK SKPYPGAELS SMGAIVWAVR AEDYNKAMEL DCLLGISNEF
     IVLIEQETKS VVFNCSCRDV IGWTSTDTSL KIFYERGECV SVGSFINNEE IKEIVKRLQF
     VSKGCESVEM TLRRNGLGQL GFHVNYEGIV ADVEPYGYAW QAGLRQGSRL VEICKVAVAT
     LSHEQMIDLL RTSVTVKVVI IPPHDDCTPR RSCSETYRMP VMEYKMNEGV SYEFKFPFRN
     NNKWQRNTSK GPHSPQVPSQ MQSPMTSRLN AGKGDGKMPP PERAANIPRS ISSDGRPLER
     RLSPGSDIYV TVSSMALARS QCRNSPSNLS SSSDTGSVGG TYRQKSMPEG FGVSRRSPAS
     IDRQNTQSDI SGSGKSTPSW QRSEDSIADQ MEPTCHLPAV SKVLPAFRES PSGRLMRQDP
     VVHLSPNKQG HSDSHYSSHS SSNTLSSNAS SAHSDEKWYD GDRTESELNS YNYLQGTSAD
     SGIDTTSYGP SHGSTASLGA ATSSPRSGPG KEKVAPLWHS SSEVISMADR TLETESHGLD
     RKAESSLSLD IHSKSQAGSS PLARENSTFS INDAASHTST MSSRHSASPV VFTSARSSPK
     EELHPAAPSQ LAPSFSSSSS SSSGPRSFYP RQGATSKYLI GWKKPEGTIN SVGFMDTRKR
     HQSDGNEIAH TRLRASTRDL RASPKPTSKS TIEEDLKKLI DLESPTPESQ KSFKFHALSS
     PQSPFPSTPT SRRALHRTLS DESIYSSQRE HFFTSRASLL DQALPNDVLF SSTYPSLPKS
     LPLRRPSYTL GMKSLHGEFS ASDSSLTDIQ ETRRQPMPDP GLMPLPDTAA DLDWSNLVDA
     AKAYEVQRAS FFAASDENHR PLSAASNSDQ LEDQALAQMK PFSSKDSSPT LASKVDQLEG
     MLKMLREDLK KEKEDKAHLQ AEVQHLREDN LRLQEESQNA SDKLKKFTEW VFNTIDMS
//