ID A0A2K6PWR4_RHIRO Unreviewed; 461 AA.
AC A0A2K6PWR4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=STAM binding protein {ECO:0000313|Ensembl:ENSRROP00000020973.1};
GN Name=STAMBP {ECO:0000313|Ensembl:ENSRROP00000020973.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000020973.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000020973.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M67C family.
CC {ECO:0000256|ARBA:ARBA00010981}.
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DR RefSeq; XP_010380023.1; XM_010381721.1.
DR RefSeq; XP_010380024.1; XM_010381722.1.
DR AlphaFoldDB; A0A2K6PWR4; -.
DR STRING; 61622.ENSRROP00000020973; -.
DR Ensembl; ENSRROT00000045157.1; ENSRROP00000020973.1; ENSRROG00000034410.1.
DR GeneTree; ENSGT00940000153710; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0032154; C:cleavage furrow; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:Ensembl.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:Ensembl.
DR CDD; cd08066; MPN_AMSH_like; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR InterPro; IPR015063; USP8_dimer.
DR PANTHER; PTHR12947; AMSH-LIKE PROTEASE; 1.
DR PANTHER; PTHR12947:SF8; STAM-BINDING PROTEIN; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08969; USP8_dimer; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 274..405
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 227..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 128..177
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 461 AA; 52444 MW; CC02621C4D8206E1 CRC64;
MVPFLTHKNL SQENLVLMSD HGDVSLPPED RVRALSQLGS AVEVNEDIPP RRYFRSGVEI
IRMASIYSEE GNIEHAFILY NKYITLFIEK LPKHRDYKSA VIPEKKDTVK KLKEIAFPKA
EELKAELLKR YTKEYTEYNE EKKKEAEELA RNMAIQQELE KEKQRVAQQK QQQLEQEQFH
AFEEMIRNQE LEKERLKIVQ EFGKVDPGLG GPLVPDLEKP SLDVFPTSPV SSTQPSDCHT
TVRPAKPPVV DRSLKPGALS NSESIPTIDG LRHVVVPGRL CPQFLQLASA NTARGVETCG
ILCGKLMRNE FTITHVLIPK QSAGSDYCNT ENEEELFLIQ DQQGLITLGW IHTHPTQTAF
LSSVDLHTHC SYQMMLPESI AIVCSPKFQE TGFFKLTDHG LEEISSCRQK GFHPHSKDPP
LFCFLSLYFN KRFECKGKEK PLKSCSHVTV VDKAVTITDL R
//
