ID   A0A2K6PXL1_RHIRO        Unreviewed;       931 AA.
AC   A0A2K6PXL1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=PMS1 homolog 1, mismatch repair system component {ECO:0000313|Ensembl:ENSRROP00000021261.1};
GN   Name=PMS1 {ECO:0000313|Ensembl:ENSRROP00000021261.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000021261.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000021261.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   RefSeq; XP_010368576.1; XM_010370274.1.
DR   RefSeq; XP_010368577.1; XM_010370275.1.
DR   AlphaFoldDB; A0A2K6PXL1; -.
DR   STRING; 61622.ENSRROP00000021261; -.
DR   Ensembl; ENSRROT00000045450.1; ENSRROP00000021261.1; ENSRROG00000034537.1.
DR   GeneID; 104667734; -.
DR   KEGG; rro:104667734; -.
DR   CTD; 5378; -.
DR   GeneTree; ENSGT00940000157085; -.
DR   OrthoDB; 4698638at2759; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd21985; HMG-box_PMS1; 1.
DR   CDD; cd03485; MutL_Trans_hPMS_1_like; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF54; PMS1 PROTEIN HOMOLOG 1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT   DOMAIN          571..639
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        571..639
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          465..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        465..481
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   931 AA;  105441 MW;  D2446827E3BAF6B6 CRC64;
     MKQLPAATVR LLSSSQIITS VVSVVKELIE NSLDAGATSI DVKLENYGFD KIEVRDNGEG
     IKAVDAPVMA MKYYTSKINS HEDLENLTTY GFRGEALGSI CCVAEVLITT RTAADNFSTQ
     YVLDGSGHIL SQKPSHLGQG TTVTALRLFK NLPVRKQFYS TAKKCKDEIK KIQDLLMSYG
     ILKPDLRIVF VHNKAVIWQK TRVSDHKMAL MSVLGTAVMN NMESFQYHCE ESQIYLSGFL
     PKCDADHSFT SLSTPERSFI FINSRPVHQK DILKLIRHHY NLKCLKESTR LYPIFFLKID
     VPTADVDVNL TPDKSQVLLQ NKESVLIALE NLMTTCYGPL PSTNSYENNE TDVSAADIVL
     SKTAETDVLF NKMESSGKNY SNVDTSVIPF QNDIPNDESG KNTDDCLNHQ ISSGDFGYGH
     CSSEISNTDK NTKNAFQDIS MSNLSWENPQ TAYSKTCFVD SVKHTQSEND NKDHIAESGE
     NEEEAGLENS LEISADEWSR GNILKNSMGE NIEPVKILVP EKSLPCKVSN NNHPSPEQTN
     LNEDLCNKKS NVIDNKSGKV TAYDLLSNRV IKKPMSASAL FVQDHRAQFL IENPKTSLED
     ATLQMEELWK TLSEDEKLKY EEKATKDLER YNSQMKRAIE QESQISLKDG RKKIKPTSAW
     NLAQKHKLKT SLSNQPKLDE LLQSQIEKRS QNIKMVQIPF SMKNLKINFE KQNKVDLEEK
     DEPCLIHNLR FPDAWLMTSK TEVMLLNPYR VEEALLFKRL LENHKLPAEP LEKPIMLTES
     LFNGSHYLDV LCKMTADDQR YSGSTYLSDP RLTANGFKIK LIPGVSITEN YLEIEGMASC
     LPFYGVADLK EILNAILNKN AKEVYECRPR KVISYLEGEA VRLSRQLPMY LSKEDIQDII
     YRMKHQFGNE IKGCVHGRPF FHHLTYLPET T
//