ID   A0A2K6PZA7_RHIRO        Unreviewed;       562 AA.
AC   A0A2K6PZA7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Acid sensing ion channel subunit 1 {ECO:0000313|Ensembl:ENSRROP00000021867.1};
GN   Name=ASIC1 {ECO:0000313|Ensembl:ENSRROP00000021867.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000021867.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000021867.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. ASIC1 subfamily. {ECO:0000256|ARBA:ARBA00038517}.
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DR   RefSeq; XP_010383664.1; XM_010385362.1.
DR   AlphaFoldDB; A0A2K6PZA7; -.
DR   Ensembl; ENSRROT00000046061.1; ENSRROP00000021867.1; ENSRROG00000034828.1.
DR   GeneID; 104679697; -.
DR   CTD; 41; -.
DR   GeneTree; ENSGT00940000158414; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 2.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF170; ACID-SENSING ION CHANNEL 1; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022461}.
FT   REGION          13..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   562 AA;  62777 MW;  E7CB4E526F5B78A5 CRC64;
     MPIRIFCSVS FSSGEEAPGP LGDIWGPHHH QQQQDISESE EEEEEKEKEA VRKEASERHS
     PIDLVAFANS CTLHGTNHIF VEGGPGPRQV LWAVAFVLAL GAFLCQVGDR VAYYLSYPHV
     TLLNEVATTE LAFPAVTLCN TNAVRLSQLS YPDLLYLAPM LGLDESDDPG VPLAPPGPEA
     FSGEPFNLHR FYNRSCHRLE DMLLYCSYQG GPCGPHNFSV VFTRYGKCYT FNSGRDGRPR
     LKTMKGGTGN GLEIMLDIQQ DEYLPVWGET DETSFEAGIK VQIHSQDEPP FIDQLGFGVA
     PGFQTFVACQ EQRLIYLPPP WGTCKAVTMD SDLDFFDSYS ITACRIDCET RYLVENCNCR
     MVHMPGDAPY CTPEQYKECA DPALDFLVEK DQEYCVCEMP CNLTRYGKEL SMVKIPSKAS
     AKYLAKKFNK SEQYIGENIL VLDIFFEVLN YETIEQKKAY EIAGLLGDIG GQMGLFIGAS
     ILTVLELFDY AYEVIKHKLC RRGKCQKEAK RSSADKGVAL SLDDVKRHNP CESLRGHPAG
     MTYAANILPH HPARGTFEDF TC
//