ID   A0A2K6Q1W2_RHIRO        Unreviewed;       371 AA.
AC   A0A2K6Q1W2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Thyroxine-binding globulin {ECO:0000256|ARBA:ARBA00039512};
DE   AltName: Full=Serpin A7 {ECO:0000256|ARBA:ARBA00043177};
DE   AltName: Full=T4-binding globulin {ECO:0000256|ARBA:ARBA00042967};
GN   Name=SERPINA7 {ECO:0000313|Ensembl:ENSRROP00000022758.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000022758.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000022758.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Major thyroid hormone transport protein in serum.
CC       {ECO:0000256|ARBA:ARBA00037352}.
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|ARBA:ARBA00009500, ECO:0000256|RuleBase:RU000411}.
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DR   AlphaFoldDB; A0A2K6Q1W2; -.
DR   Ensembl; ENSRROT00000046956.1; ENSRROP00000022758.1; ENSRROG00000035235.1.
DR   GeneTree; ENSGT00940000161113; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   PANTHER; PTHR11461:SF375; THYROXINE-BINDING GLOBULIN; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..371
FT                   /note="Thyroxine-binding globulin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014354041"
FT   DOMAIN          51..366
FT                   /note="Serpin"
FT                   /evidence="ECO:0000259|SMART:SM00093"
SQ   SEQUENCE   371 AA;  41274 MW;  A6C423FEDD0A2322 CRC64;
     MSPFLYLGLL VLGLHSTIHC ASPEGKVTAC HSPQQNATLY KMSSINADFA FNLYRRFTVE
     TPDKNIFFSP VSISAALVML SLGACSSTQT EIVETLGFNL TDTPIVDIQH GFQHLICSLN
     FPKKELELQI GNALFIGKHL KPQAKFLDDV KTLYETEVFS TDFSNISAAE QEINSHVEMQ
     TKGKVVGLIQ DLKPNTIMVL VNYINFKAQW ANPFDPSKTE DSSSFLIDKT TTVQVPMMHQ
     MEQYYHLVDM ELNCTVLQMD YSKNALALFV LPKEGQMESV EAAMSSKTLK KWNRLLQKGW
     VDLFVPKVSI SATYDLGATL LKMGIQRAYA ENADFSGLTE DNGLKLSNTF PKTVPVSSET
     SRICSPHTGC P
//