ID A0A2K6Q2D4_RHIRO Unreviewed; 579 AA.
AC A0A2K6Q2D4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Keratin, type II cytoskeletal 1b {ECO:0000313|Ensembl:ENSRROP00000022933.1};
GN Name=KRT77 {ECO:0000313|Ensembl:ENSRROP00000022933.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000022933.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000022933.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_010372263.1; XM_010373961.1.
DR AlphaFoldDB; A0A2K6Q2D4; -.
DR STRING; 61622.ENSRROP00000022933; -.
DR Ensembl; ENSRROT00000047132.1; ENSRROP00000022933.1; ENSRROG00000035323.1.
DR GeneID; 104670622; -.
DR KEGG; rro:104670622; -.
DR GeneTree; ENSGT00940000162397; -.
DR OMA; VQTHISD; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF24; KERATIN, TYPE II CYTOSKELETAL 1B; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 169..482
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 539..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 380..460
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 550..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 62310 MW; AE16416981392FDE CRC64;
MSRQYSSQSA FSSRSRQVYR TSFSAGSGGG SRAVGSVCYT RGRCGGGGYG IHGRGFGSRS
LYNLGGSRSI SISLVGRSAS GFRHGGGVGG FGGVRSFGVG NIGAGGFGGG GFGGGGFGGA
GFGASNFGLG GFGPSCPPGG IQEVTINQSL LEPLHLEVDP EIQRIKTQER EQIMVLNNKF
ASFIDKVRFL EQQNQVLQTK WELLQQVNTS TGTNNLEPLL ENYISDLRKQ VDLLNAEQMR
QNTEVRSMQD VVEDYKSKYE DEISKRTGSE NDFVVLKKDV DAAYVSKVDL ESRVDTLTGE
VNFLKYLFLT ELSQMQTHIS DTNVILSMDN NRSLDLDSII DAVRTQYELI AQRSKDEAEA
LYQTKYQELQ ITAGRHGDDL KNSKMEIAEL NRTVQRLQAE ISNVKKQIEQ MQSLISDAEE
RGEQALQDAQ QKLQDLEEAL QQSKEELARL LRDYQAMLGA KLSLDVEIAT YRQLLEGEES
RMSGELQSHV SISVQNSQVS IRGGAEGGGS YVSGGYGGGS GGGYGGGRSY RGGGARGGSG
GGYGSGGGSY GGSGRSSRGS SRVQIIQTST NTSHRRILE
//
