ID A0A2K6Q2Q3_RHIRO Unreviewed; 595 AA.
AC A0A2K6Q2Q3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=CBFA2/RUNX1 partner transcriptional co-repressor 2 {ECO:0000313|Ensembl:ENSRROP00000023056.1};
GN Name=CBFA2T2 {ECO:0000313|Ensembl:ENSRROP00000023056.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000023056.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000023056.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CBFA2T family.
CC {ECO:0000256|ARBA:ARBA00011004}.
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DR RefSeq; XP_010358889.1; XM_010360587.1.
DR AlphaFoldDB; A0A2K6Q2Q3; -.
DR Ensembl; ENSRROT00000047257.1; ENSRROP00000023056.1; ENSRROG00000035361.1.
DR GeneID; 104660283; -.
DR KEGG; rro:104660283; -.
DR CTD; 9139; -.
DR GeneTree; ENSGT00950000183176; -.
DR OrthoDB; 5314634at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 6.10.250.230; -; 1.
DR Gene3D; 1.20.120.1110; TAFH/NHR1 domain; 1.
DR InterPro; IPR013289; CBFA2T1/2/3.
DR InterPro; IPR013291; MTGR1.
DR InterPro; IPR014896; NHR2.
DR InterPro; IPR037249; TAFH/NHR1_dom_sf.
DR InterPro; IPR003894; TAFH_NHR1.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR10379; MTG8 ETO EIGHT TWENTY ONE PROTEIN; 1.
DR PANTHER; PTHR10379:SF13; PROTEIN CBFA2T2; 1.
DR Pfam; PF08788; NHR2; 1.
DR Pfam; PF07531; TAFH; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR PRINTS; PR01875; ETOFAMILY.
DR PRINTS; PR01877; MTGR1PROTEIN.
DR SMART; SM00549; TAFH; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF158553; TAFH domain-like; 1.
DR PROSITE; PS51119; TAFH; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 104..199
FT /note="TAFH"
FT /evidence="ECO:0000259|PROSITE:PS51119"
FT DOMAIN 498..534
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..51
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 595 AA; 65918 MW; 01B65CD032E5B962 CRC64;
MVGVPGAAAL QLGPEKRVPA MPGSPVEVKI QSRSSPPTMP PLPPINPGGP RPVSFTPTAL
SNGINHSPPT LNGAPSPPQR FSNGPASSTS SALTNQQLPA TCGARQLSKL KRFLTTLQQF
GNDISPEIGE KVRTLVLALV NSTVTIEEFH CKLQEATNFP LRPFVIPFLK ANLPLLQREL
LHCARAAKQT PSQYLAQHEH LLLNTSIASP ADSSELLMEV HGNGKRPSPE RREENSFDRD
TIAPEPPAKR VCTISPAPRH SPALTVPLMN PGGQFHPTPP PLQHYTLEDI ATSHLYREPN
KMLEHREVRE RHHSLGLNGG YQDELVDHRL TEREWADEWK HLDHALNCIM EMVEKTRRSM
AVLRRCQESD REELNYWKRR YNENTELRKT GTELVSRQHS PGSTDSLSND SQREFNSRPG
TGYVPVEFWK KTEEAVNKVK IQAMSEVQKA VAEAEQKAFE VIATERARME QTIADVKRQA
AEDAFLVINE QEESTENCWN CGRKASETCS GCNIARYCGS FCQHKDWERH HRLCGQNLHG
QSPHSQGRPL LPVGRGSSAR SADCSVPSPA LDKTSATTSR SSTPASVTAI DTNGL
//
