ID A0A2K6Q5W7_RHIRO Unreviewed; 1138 AA.
AC A0A2K6Q5W7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|Ensembl:ENSRROP00000024177.1};
GN Name=ARHGEF10 {ECO:0000313|Ensembl:ENSRROP00000024177.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000024177.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000024177.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6Q5W7; -.
DR Ensembl; ENSRROT00000048388.1; ENSRROP00000024177.1; ENSRROG00000035889.1.
DR GeneTree; ENSGT00940000153798; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 397..584
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 280..331
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 567..598
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1138 AA; 127119 MW; 14F2A5D7DE8729F5 CRC64;
MDQREPPHPA PAENEMKYDT NNNEEEEGEQ FDFDSGDEIP EADRQAPSAP ETGGAGASEA
PAPTGGEDRA GAETTPAVEA AKLVLPMKVN PYSVIDITPF QEDQPPAPAP STEEESVGLH
VPCGYSVPVP CGYAVPSNLP LLLPAYSSPV IIRAMSLDEE AETAEVMEDR QPNSLSSEEP
PNSEDQVSRE DSALARWAAD PANTAWMENP EEAIYDDVPR ENSDSEPDEM IYDDVENGDE
GGNSSLEYGW SSSEFESYEE QSDSECKNGI PRSFLRSNHK KQLSHDLTRL KEHYEKKMRE
LMASTVGAVE IQQLRQKHEL KMQKLVKAAK DGTKDGLERT RAAVKRGRSF IRTKSLIAQD
HRSSLEEEQN LFIDVDCKHP EAILTPMPEG LSQQQVVRRY ILGSVVDSEK NYVDALKRIL
EQYEKPLSEM EPKFLSERKL KTVFYRVKEI LQCHSLFQIA LASRVSEWDS VEMIGDVFVA
SFSKSMVLDA YSEYVNNFST AVAVLKKTCA TKPAFLEFLK QEQEASPDRT TLYSLMMKPI
QRFPQFILLL QDMLKNTSKG HPDRLPLQMA LTELETLAEK LNERKRDADQ RCEVKQIAKA
INERYLNKLL SSGSRYLIRS DDMIETVYND RGEIVKTKER RVFMLNDVLM CATVSSRASH
DSRVMSSQRY LLKWSVPLGH VDAIEYGSSP GAGEHSRHLA VHPPESLAVV ANAKPNKVYM
GPGQLYQDLQ NLLHDLNVIG QITQLIGNLK GNYQNLNQSV AHDWTSGLQR LILKKEDEIR
AADCCRIQLQ LPGKQDKSGR PTFFTAVFNT FTPAIKESWV NSLQMAKLAL EEENHMGWFC
VEDDGNHIKK EKHPLLVGHM PVMVAKQQEF KIECAAYNPE PYLNNESQPD SFSTAHGFLW
IGSCTHQMGQ IAIVSFQNST PKVIECFNVE SRILCMLYIP VEEKRREPGA PLDPETSAVR
ASEVPTICVG TEEGSISIYK SSQGSKKVRL QHFFTPEKST VMSLACTSQS LYAGLVNGEV
ASYARAPDGS WDSEPQKVIK LGVLPVRSLL MMEDTLWAAS GGQVFIISVE THAVEGQLEA
HQEEGMVISH MAVAGVGIWI AFTSGSTLRL FHTETLKHLQ DINIATPVHN MLPGHRGP
//
