ID   A0A2K6Q7X9_RHIRO        Unreviewed;       928 AA.
AC   A0A2K6Q7X9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL6 {ECO:0000313|Ensembl:ENSRROP00000024880.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000024880.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000024880.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   RefSeq; XP_010380793.1; XM_010382491.1.
DR   Ensembl; ENSRROT00000049089.1; ENSRROP00000024875.1; ENSRROG00000036096.1.
DR   Ensembl; ENSRROT00000049094.1; ENSRROP00000024880.1; ENSRROG00000036096.1.
DR   GeneID; 104677464; -.
DR   KEGG; rro:104677464; -.
DR   CTD; 114880; -.
DR   GeneTree; ENSGT00940000156791; -.
DR   OrthoDB; 960at2759; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          86..181
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          414..441
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   928 AA;  105252 MW;  00E03E2DE8A21E68 CRC64;
     MSSDEKGISP AHKTSTPTHR SASSSISSQR DSRQSIHILE RTASSSTEPS VSRQLLEPEP
     VPLSKEADSW EIIEGLKIGQ TNVQKPDKHE GFMLKKRKWP LKGWHKRFFV LDNGMLKYSK
     APLDIQKGKV HGSIDVGLSV MSIKKKARRI DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR
     LYRQNEIVRS PRDASFHIFP STSTAESSPA ANVSVVDGKV QPNSFPWQSP LPCSNSLPAT
     CTTGQSKVAA WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQEG
     PPAKGQFSTT RRRQRLAAAV ATTVPFSATM SPVRLHSSNP NLCADIEFQT PPSHLTDPLE
     SSTDYTKLQE EFCLIAQKVH SLLKSAFNSI AIEKEKLKQM VSEQDHSKGH STQMARLRQS
     LSQALNQNAE LRSRLNRIHS ESIICDQVVS VNIIPSPDEA GEQIHVSLPL SQQVANESRL
     SMSESVSEFF DAQEVLISAS SSENEASDDE SYISDVSDNI SEDNTSVADN ISRQILNGEL
     TGGAFRNGRR TCLPAPCPDT SNINLWNILR NNIGKDLSKV SMPVELNEPL NTLQHLCEEM
     EYSELLDKAS ETDDPYERMV LVAAFAVSGY CSTYFRAGSK PFNPVLGETY ECIREDKGFR
     FFSEQVSHHP PISACHCESK NFVFWQDIRW KNKFWGKSME ILPVGTLNVT LPKYGDYYVW
     NKVTTCIHNI LSGRRWIEHY GEVTIRNTKS SVCICKLTFV KVNYWNSNMN EIQGVVIDQE
     GKVVHRLFGK WHEGLYCGVA PSAKCIWRPG SMPTNYELYY GFTRFAIELN ELDPVLKDLL
     PPTDARFRPD QRFLEEGNLE AAASEKQRVE ELQRSRRRYM EENNLEHIPK FFKKVIDANQ
     REAWVSNDTY WELRKDPGFS KVDSPVLW
//