ID   A0A2K6Q813_RHIRO        Unreviewed;       942 AA.
AC   A0A2K6Q813;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL6 {ECO:0000313|Ensembl:ENSRROP00000024899.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000024899.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000024899.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   AlphaFoldDB; A0A2K6Q813; -.
DR   Ensembl; ENSRROT00000049114.1; ENSRROP00000024899.1; ENSRROG00000036096.1.
DR   GeneTree; ENSGT00940000156791; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          86..181
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          443..470
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   942 AA;  107462 MW;  CA1E57BE62236BE1 CRC64;
     MSSDEKGISP AHKTSTPTHR SASSSISSQR DSRQSIHILE RTASSSTEPS VSRQLLEPEP
     VPLSKEADSW EIIEGLKIGQ TNVQKPDKHE GFMLKKRKWP LKGWHKRFFV LDNGMLKYSK
     APLDIQKGKV HGSIDVGLSV MSIKKKARRI DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR
     LYRQNEIVRS PRDASFHIFP STSTAESSPA ANVSVVDGKV QPNSFPWQSP LPCSNSLPAT
     CTTGQSKVAA WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQAN
     CVDISKKDKR VTRRWRTKSV SKDTKIQLGP FCVGECETMH CCSLIICVFP FQVPFSATMS
     PVRLHSSNPN LCADIEFQTP PSHLTDPLES STDYTKLQEE FCLIAQKVHS LLKSAFNSIA
     IEKEKLKQMV SEQDHSKGHS TQMARLRQSL SQALNQNAEL RSRLNRIHSE SIICDQVVSV
     NIIPSPDEVR LILNRCRVPI FLASKFTVYF CLFISSSFTA SDDESYISDV SDNISEDNTS
     VADNISRQIL NGELTGGAFR NGRRTCLPAP CPDTSNINLW NILRNNIGKD LSKVSMPVEL
     NEPLNTLQHL CEEMEYSELL DKASETDDPY ERMVLVAAFA VSGYCSTYFR AGSKPFNPVL
     GETYECIRED KGFRFFSEQV SHHPPISACH CESKNFVFWQ DIRWKNKFWG KSMEILPVGT
     LNVTLPKYGD YYVWNKVTTC IHNILSGRRW IEHYGEVTIR NTKSSVCICK LTFVKVNYWN
     SNMNEIQGVV IDQEGKVVHR LFGKWHEGLY CGVAPSAKCI WRPGSMPTNY ELYYGFTRFA
     IELNELDPVL KDLLPPTDAR FRPDQRFLEE GNLEAAASEK QRVEELQRSR RRYMEENNLE
     HIPKFFKKVI DANQREAWVS NDTYWELRKD PGFSKVDSPV LW
//